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Self-reported sleep relates to hippocampal atrophy across the adult lifespan - results from the Lifebrain consortium

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Self-reported sleep relates to hippocampal atrophy across the adult lifespan - results from the Lifebrain consortium. / Fjell, Anders M; Sørensen, Øystein; Amlien, Inge K; Bartrés-Faz, David; Bros, Didac Maciá; Buchmann, Nikolaus; Demuth, Ilja; Drevon, Christian A; Düzel, Sandra; Ebmeier, Klaus P; Idland, Ane-Victoria; Kietzmann, Tim C; Kievit, Rogier; Kühn, Simone; Lindenberger, Ulman; Mowinckel, Athanasia M; Nyberg, Lars; Price, Darren; Sexton, Claire E; Solé-Padullés, Cristina; Pudas, Sara; Sederevicius, Donatas; Suri, Sana; Wagner, Gerd; Watne, Leiv Otto; Westerhausen, René; Zsoldos, Enikő; Walhovd, Kristine B.

in: SLEEP, Jahrgang 43, Nr. 5, 12.05.2020, S. 280.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Fjell, AM, Sørensen, Ø, Amlien, IK, Bartrés-Faz, D, Bros, DM, Buchmann, N, Demuth, I, Drevon, CA, Düzel, S, Ebmeier, KP, Idland, A-V, Kietzmann, TC, Kievit, R, Kühn, S, Lindenberger, U, Mowinckel, AM, Nyberg, L, Price, D, Sexton, CE, Solé-Padullés, C, Pudas, S, Sederevicius, D, Suri, S, Wagner, G, Watne, LO, Westerhausen, R, Zsoldos, E & Walhovd, KB 2020, 'Self-reported sleep relates to hippocampal atrophy across the adult lifespan - results from the Lifebrain consortium', SLEEP, Jg. 43, Nr. 5, S. 280. https://doi.org/10.1093/sleep/zsz280

APA

Fjell, A. M., Sørensen, Ø., Amlien, I. K., Bartrés-Faz, D., Bros, D. M., Buchmann, N., Demuth, I., Drevon, C. A., Düzel, S., Ebmeier, K. P., Idland, A-V., Kietzmann, T. C., Kievit, R., Kühn, S., Lindenberger, U., Mowinckel, A. M., Nyberg, L., Price, D., Sexton, C. E., ... Walhovd, K. B. (2020). Self-reported sleep relates to hippocampal atrophy across the adult lifespan - results from the Lifebrain consortium. SLEEP, 43(5), 280. https://doi.org/10.1093/sleep/zsz280

Vancouver

Fjell AM, Sørensen Ø, Amlien IK, Bartrés-Faz D, Bros DM, Buchmann N et al. Self-reported sleep relates to hippocampal atrophy across the adult lifespan - results from the Lifebrain consortium. SLEEP. 2020 Mai 12;43(5):280. https://doi.org/10.1093/sleep/zsz280

Bibtex

@article{4f3aca09111c465f91891bfcd03f7340,
title = "Self-reported sleep relates to hippocampal atrophy across the adult lifespan - results from the Lifebrain consortium",
abstract = "OBJECTIVES: Poor sleep is associated with multiple age-related neurodegenerative and neuropsychiatric conditions. The hippocampus plays a special role in sleep and sleep-dependent cognition, and accelerated hippocampal atrophy is typically seen with higher age. Hence, it is critical to establish how the relationship between sleep and hippocampal volume loss unfolds across the adult lifespan.METHODS: Self-reported sleep measures and MRI-derived hippocampal volumes were obtained from 3105 cognitively normal participants (18-90 years) from major European brain studies in the Lifebrain consortium. Hippocampal volume change was estimated from 5116 MRIs from 1299 participants for whom longitudinal MRIs were available, followed up to 11 years with a mean interval of 3.3 years. Cross-sectional analyses were repeated in a sample of 21390 participants from the UK Biobank.RESULTS: No cross-sectional sleep - hippocampal volume relationships were found. However, worse sleep quality, efficiency, problems, and daytime tiredness were related to greater hippocampal volume loss over time, with high scorers showing 0.22% greater annual loss than low scorers. The relationship between sleep and hippocampal atrophy did not vary across age. Simulations showed that the observed longitudinal effects were too small to be detected as age-interactions in the cross-sectional analyses.CONCLUSIONS: Worse self-reported sleep is associated with higher rates of hippocampal volume decline across the adult lifespan. This suggests that sleep is relevant to understand individual differences in hippocampal atrophy, but limited effect sizes call for cautious interpretation.",
author = "Fjell, {Anders M} and {\O}ystein S{\o}rensen and Amlien, {Inge K} and David Bartr{\'e}s-Faz and Bros, {Didac Maci{\'a}} and Nikolaus Buchmann and Ilja Demuth and Drevon, {Christian A} and Sandra D{\"u}zel and Ebmeier, {Klaus P} and Ane-Victoria Idland and Kietzmann, {Tim C} and Rogier Kievit and Simone K{\"u}hn and Ulman Lindenberger and Mowinckel, {Athanasia M} and Lars Nyberg and Darren Price and Sexton, {Claire E} and Cristina Sol{\'e}-Padull{\'e}s and Sara Pudas and Donatas Sederevicius and Sana Suri and Gerd Wagner and Watne, {Leiv Otto} and Ren{\'e} Westerhausen and Enik{\H o} Zsoldos and Walhovd, {Kristine B}",
note = "{\textcopyright} Sleep Research Society 2019. Published by Oxford University Press [on behalf of the Sleep Research Society].",
year = "2020",
month = may,
day = "12",
doi = "10.1093/sleep/zsz280",
language = "English",
volume = "43",
pages = "280",
journal = "SLEEP",
issn = "0161-8105",
publisher = "American Academy of Sleep Medicine",
number = "5",

}

RIS

TY - JOUR

T1 - Self-reported sleep relates to hippocampal atrophy across the adult lifespan - results from the Lifebrain consortium

AU - Fjell, Anders M

AU - Sørensen, Øystein

AU - Amlien, Inge K

AU - Bartrés-Faz, David

AU - Bros, Didac Maciá

AU - Buchmann, Nikolaus

AU - Demuth, Ilja

AU - Drevon, Christian A

AU - Düzel, Sandra

AU - Ebmeier, Klaus P

AU - Idland, Ane-Victoria

AU - Kietzmann, Tim C

AU - Kievit, Rogier

AU - Kühn, Simone

AU - Lindenberger, Ulman

AU - Mowinckel, Athanasia M

AU - Nyberg, Lars

AU - Price, Darren

AU - Sexton, Claire E

AU - Solé-Padullés, Cristina

AU - Pudas, Sara

AU - Sederevicius, Donatas

AU - Suri, Sana

AU - Wagner, Gerd

AU - Watne, Leiv Otto

AU - Westerhausen, René

AU - Zsoldos, Enikő

AU - Walhovd, Kristine B

N1 - © Sleep Research Society 2019. Published by Oxford University Press [on behalf of the Sleep Research Society].

PY - 2020/5/12

Y1 - 2020/5/12

N2 - OBJECTIVES: Poor sleep is associated with multiple age-related neurodegenerative and neuropsychiatric conditions. The hippocampus plays a special role in sleep and sleep-dependent cognition, and accelerated hippocampal atrophy is typically seen with higher age. Hence, it is critical to establish how the relationship between sleep and hippocampal volume loss unfolds across the adult lifespan.METHODS: Self-reported sleep measures and MRI-derived hippocampal volumes were obtained from 3105 cognitively normal participants (18-90 years) from major European brain studies in the Lifebrain consortium. Hippocampal volume change was estimated from 5116 MRIs from 1299 participants for whom longitudinal MRIs were available, followed up to 11 years with a mean interval of 3.3 years. Cross-sectional analyses were repeated in a sample of 21390 participants from the UK Biobank.RESULTS: No cross-sectional sleep - hippocampal volume relationships were found. However, worse sleep quality, efficiency, problems, and daytime tiredness were related to greater hippocampal volume loss over time, with high scorers showing 0.22% greater annual loss than low scorers. The relationship between sleep and hippocampal atrophy did not vary across age. Simulations showed that the observed longitudinal effects were too small to be detected as age-interactions in the cross-sectional analyses.CONCLUSIONS: Worse self-reported sleep is associated with higher rates of hippocampal volume decline across the adult lifespan. This suggests that sleep is relevant to understand individual differences in hippocampal atrophy, but limited effect sizes call for cautious interpretation.

AB - OBJECTIVES: Poor sleep is associated with multiple age-related neurodegenerative and neuropsychiatric conditions. The hippocampus plays a special role in sleep and sleep-dependent cognition, and accelerated hippocampal atrophy is typically seen with higher age. Hence, it is critical to establish how the relationship between sleep and hippocampal volume loss unfolds across the adult lifespan.METHODS: Self-reported sleep measures and MRI-derived hippocampal volumes were obtained from 3105 cognitively normal participants (18-90 years) from major European brain studies in the Lifebrain consortium. Hippocampal volume change was estimated from 5116 MRIs from 1299 participants for whom longitudinal MRIs were available, followed up to 11 years with a mean interval of 3.3 years. Cross-sectional analyses were repeated in a sample of 21390 participants from the UK Biobank.RESULTS: No cross-sectional sleep - hippocampal volume relationships were found. However, worse sleep quality, efficiency, problems, and daytime tiredness were related to greater hippocampal volume loss over time, with high scorers showing 0.22% greater annual loss than low scorers. The relationship between sleep and hippocampal atrophy did not vary across age. Simulations showed that the observed longitudinal effects were too small to be detected as age-interactions in the cross-sectional analyses.CONCLUSIONS: Worse self-reported sleep is associated with higher rates of hippocampal volume decline across the adult lifespan. This suggests that sleep is relevant to understand individual differences in hippocampal atrophy, but limited effect sizes call for cautious interpretation.

U2 - 10.1093/sleep/zsz280

DO - 10.1093/sleep/zsz280

M3 - SCORING: Journal article

C2 - 31738420

VL - 43

SP - 280

JO - SLEEP

JF - SLEEP

SN - 0161-8105

IS - 5

ER -