Selective changes of ocular vestibular myogenic potentials in Parkinson's disease
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Selective changes of ocular vestibular myogenic potentials in Parkinson's disease. / Pötter-Nerger, Monika; Govender, Sendhil; Deuschl, Günther; Volkmann, Jens; Colebatch, J G.
in: MOVEMENT DISORD, Jahrgang 30, Nr. 4, 04.2015, S. 584-9.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Selective changes of ocular vestibular myogenic potentials in Parkinson's disease
AU - Pötter-Nerger, Monika
AU - Govender, Sendhil
AU - Deuschl, Günther
AU - Volkmann, Jens
AU - Colebatch, J G
N1 - © 2014 International Parkinson and Movement Disorder Society.
PY - 2015/4
Y1 - 2015/4
N2 - BACKGROUND: Vestibular evoked myogenic potentials represent electrophysiological tools to measure vestibular reflex actions at different levels of the brainstem in Parkinson's disease.OBJECTIVE: To investigate cervical and ocular vestibular myogenic potentials in Parkinsonian patients with mild disability.METHODS: In 13 Parkinsonian patients and 13 age-matched healthy controls, cervical and ocular vestibular myogenic potentials were recorded after unilateral air-conducted tone bursts and bone-conducted stimuli delivered at the forehead or mastoids.RESULTS: In contrast to relatively preserved cervical vestibular evoked myogenic potentials, ocular vestibular evoked myogenic potentials were significantly delayed and of reduced amplitude, particularly after impulsive stimulation in Parkinsonian patients. Levodopa had no significant effect on either type of response.CONCLUSION: In mild to moderate Parkinson's disease, altered ocular vestibular myogenic potentials may indicate early functional involvement of the upper brainstem, in contrast to preserved lower brainstem function as reflected by normal cervical vestibular myogenic potentials.
AB - BACKGROUND: Vestibular evoked myogenic potentials represent electrophysiological tools to measure vestibular reflex actions at different levels of the brainstem in Parkinson's disease.OBJECTIVE: To investigate cervical and ocular vestibular myogenic potentials in Parkinsonian patients with mild disability.METHODS: In 13 Parkinsonian patients and 13 age-matched healthy controls, cervical and ocular vestibular myogenic potentials were recorded after unilateral air-conducted tone bursts and bone-conducted stimuli delivered at the forehead or mastoids.RESULTS: In contrast to relatively preserved cervical vestibular evoked myogenic potentials, ocular vestibular evoked myogenic potentials were significantly delayed and of reduced amplitude, particularly after impulsive stimulation in Parkinsonian patients. Levodopa had no significant effect on either type of response.CONCLUSION: In mild to moderate Parkinson's disease, altered ocular vestibular myogenic potentials may indicate early functional involvement of the upper brainstem, in contrast to preserved lower brainstem function as reflected by normal cervical vestibular myogenic potentials.
KW - Aged
KW - Antiparkinson Agents
KW - Bone Conduction
KW - Case-Control Studies
KW - Electromyography
KW - Female
KW - Humans
KW - Male
KW - Parkinson Disease
KW - Reaction Time
KW - Vestibular Evoked Myogenic Potentials
U2 - 10.1002/mds.26114
DO - 10.1002/mds.26114
M3 - SCORING: Journal article
C2 - 25545048
VL - 30
SP - 584
EP - 589
JO - MOVEMENT DISORD
JF - MOVEMENT DISORD
SN - 0885-3185
IS - 4
ER -