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Selectin-deficiency reduces the number of spontaneous metastases in a xenograft model of human breast cancer.

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Selectin-deficiency reduces the number of spontaneous metastases in a xenograft model of human breast cancer. / Stübke, Katrin; Wicklein, Daniel; Herich, Lena; Schumacher, Udo; Nehmann, Nina.

in: CANCER LETT, Jahrgang 321, Nr. 1, 1, 2012, S. 89-99.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Stübke, K, Wicklein, D, Herich, L, Schumacher, U & Nehmann, N 2012, 'Selectin-deficiency reduces the number of spontaneous metastases in a xenograft model of human breast cancer.', CANCER LETT, Jg. 321, Nr. 1, 1, S. 89-99. <http://www.ncbi.nlm.nih.gov/pubmed/22366582?dopt=Citation>

APA

Stübke, K., Wicklein, D., Herich, L., Schumacher, U., & Nehmann, N. (2012). Selectin-deficiency reduces the number of spontaneous metastases in a xenograft model of human breast cancer. CANCER LETT, 321(1), 89-99. [1]. http://www.ncbi.nlm.nih.gov/pubmed/22366582?dopt=Citation

Vancouver

Stübke K, Wicklein D, Herich L, Schumacher U, Nehmann N. Selectin-deficiency reduces the number of spontaneous metastases in a xenograft model of human breast cancer. CANCER LETT. 2012;321(1):89-99. 1.

Bibtex

@article{446545912a4e4687ac2b9f695b6edd27,
title = "Selectin-deficiency reduces the number of spontaneous metastases in a xenograft model of human breast cancer.",
abstract = "Metastasis formation is a complex process still poorly understood. Previous work in a colon cancer xenograft model showed that E(ndothelial) and P(latelet) selectins mediate spontaneous metastasis to the lungs. To investigate the functional role of selectins in breast cancer, human DU4475 breast cancer cells were injected subcutaneously into pfp-/-rag2-/- mice and in all their selectin-deficient variants (EP-/-, E-/- and P-/-). Pfp-/-rag2-/- mice as well as all their selectin-deficient variants developed primary tumours and spontaneous metastases. Compared with the wild-type mice, disseminated tumours cells were significantly lower (74% reduction, P=0.046) in the bone marrow of selectin-deficient mice. Pfp-/-rag2-/- mice developed significantly higher numbers of lung metastases (6644.83±741.77) than the E-/- (4053.33±112.58; P=0.002) and the EP-/- pfp-/-rag2-/- mice (4665.65±754.50; P",
author = "Katrin St{\"u}bke and Daniel Wicklein and Lena Herich and Udo Schumacher and Nina Nehmann",
year = "2012",
language = "English",
volume = "321",
pages = "89--99",
journal = "CANCER LETT",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Selectin-deficiency reduces the number of spontaneous metastases in a xenograft model of human breast cancer.

AU - Stübke, Katrin

AU - Wicklein, Daniel

AU - Herich, Lena

AU - Schumacher, Udo

AU - Nehmann, Nina

PY - 2012

Y1 - 2012

N2 - Metastasis formation is a complex process still poorly understood. Previous work in a colon cancer xenograft model showed that E(ndothelial) and P(latelet) selectins mediate spontaneous metastasis to the lungs. To investigate the functional role of selectins in breast cancer, human DU4475 breast cancer cells were injected subcutaneously into pfp-/-rag2-/- mice and in all their selectin-deficient variants (EP-/-, E-/- and P-/-). Pfp-/-rag2-/- mice as well as all their selectin-deficient variants developed primary tumours and spontaneous metastases. Compared with the wild-type mice, disseminated tumours cells were significantly lower (74% reduction, P=0.046) in the bone marrow of selectin-deficient mice. Pfp-/-rag2-/- mice developed significantly higher numbers of lung metastases (6644.83±741.77) than the E-/- (4053.33±112.58; P=0.002) and the EP-/- pfp-/-rag2-/- mice (4665.65±754.50; P

AB - Metastasis formation is a complex process still poorly understood. Previous work in a colon cancer xenograft model showed that E(ndothelial) and P(latelet) selectins mediate spontaneous metastasis to the lungs. To investigate the functional role of selectins in breast cancer, human DU4475 breast cancer cells were injected subcutaneously into pfp-/-rag2-/- mice and in all their selectin-deficient variants (EP-/-, E-/- and P-/-). Pfp-/-rag2-/- mice as well as all their selectin-deficient variants developed primary tumours and spontaneous metastases. Compared with the wild-type mice, disseminated tumours cells were significantly lower (74% reduction, P=0.046) in the bone marrow of selectin-deficient mice. Pfp-/-rag2-/- mice developed significantly higher numbers of lung metastases (6644.83±741.77) than the E-/- (4053.33±112.58; P=0.002) and the EP-/- pfp-/-rag2-/- mice (4665.65±754.50; P

M3 - SCORING: Journal article

VL - 321

SP - 89

EP - 99

JO - CANCER LETT

JF - CANCER LETT

SN - 0304-3835

IS - 1

M1 - 1

ER -