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Seasonal variation and high multiplicity of first Plasmodium falciparum infections in children from a holoendemic area in Ghana, West Africa

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Seasonal variation and high multiplicity of first Plasmodium falciparum infections in children from a holoendemic area in Ghana, West Africa. / Kobbe, Robin; Neuhoff, Rieke; Marks, Florian; Adjei, Samuel; Langefeld, Iris; von Reden, Claudia; Adjei, Ohene; Meyer, Christian G; May, Jürgen.

in: TROP MED INT HEALTH, Jahrgang 11, Nr. 5, 01.05.2006, S. 613-9.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kobbe, R, Neuhoff, R, Marks, F, Adjei, S, Langefeld, I, von Reden, C, Adjei, O, Meyer, CG & May, J 2006, 'Seasonal variation and high multiplicity of first Plasmodium falciparum infections in children from a holoendemic area in Ghana, West Africa', TROP MED INT HEALTH, Jg. 11, Nr. 5, S. 613-9. https://doi.org/10.1111/j.1365-3156.2006.01618.x

APA

Kobbe, R., Neuhoff, R., Marks, F., Adjei, S., Langefeld, I., von Reden, C., Adjei, O., Meyer, C. G., & May, J. (2006). Seasonal variation and high multiplicity of first Plasmodium falciparum infections in children from a holoendemic area in Ghana, West Africa. TROP MED INT HEALTH, 11(5), 613-9. https://doi.org/10.1111/j.1365-3156.2006.01618.x

Vancouver

Kobbe R, Neuhoff R, Marks F, Adjei S, Langefeld I, von Reden C et al. Seasonal variation and high multiplicity of first Plasmodium falciparum infections in children from a holoendemic area in Ghana, West Africa. TROP MED INT HEALTH. 2006 Mai 1;11(5):613-9. https://doi.org/10.1111/j.1365-3156.2006.01618.x

Bibtex

@article{f731d3522446442596fdd8490cb29692,
title = "Seasonal variation and high multiplicity of first Plasmodium falciparum infections in children from a holoendemic area in Ghana, West Africa",
abstract = "OBJECTIVE: To assess the prevalence and multiplicity of Plasmodium falciparum infections in Ghanaian infants.METHOD: In an epidemiological study in an area holoendemic for malaria in Ghana, the prevalence and multiplicity of P. falciparum infections (MOI) were assessed in 1069 three month-old infants by typing of the genes encoding the merozoite surface proteins 1 and 2 (msp-1, msp-2) over a recruitment period of one year. Alleles were amplified using allele family-specific polymerase chain reaction (PCR) assays and determined according to their length polymorphisms on a genetic analyzer.RESULTS: The occurrence of early infections was dependent on the season (month-stratified prevalence 6.4-29.0%). Diversity of msp-alleles was extensive and significantly higher in the dry than in the rainy season.CONCLUSIONS: The level of infection prevalence and the high multiplicity of infections (median 4, maximum 14 strains per isolate) in the first months of life indicate early contacts with parasites exhibiting a wide repertoire of antigens and, most likely, multiple infections per single mosquito bite.",
keywords = "Animals, Antigens, Protozoan, Biodiversity, DNA, Protozoan, Endemic Diseases, Genotype, Ghana, Humans, Infant, Malaria, Falciparum, Merozoite Surface Protein 1, Plasmodium falciparum, Polymerase Chain Reaction, Prevalence, Protozoan Proteins, Randomized Controlled Trials as Topic, Seasons",
author = "Robin Kobbe and Rieke Neuhoff and Florian Marks and Samuel Adjei and Iris Langefeld and {von Reden}, Claudia and Ohene Adjei and Meyer, {Christian G} and J{\"u}rgen May",
year = "2006",
month = may,
day = "1",
doi = "10.1111/j.1365-3156.2006.01618.x",
language = "English",
volume = "11",
pages = "613--9",
journal = "TROP MED INT HEALTH",
issn = "1360-2276",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - Seasonal variation and high multiplicity of first Plasmodium falciparum infections in children from a holoendemic area in Ghana, West Africa

AU - Kobbe, Robin

AU - Neuhoff, Rieke

AU - Marks, Florian

AU - Adjei, Samuel

AU - Langefeld, Iris

AU - von Reden, Claudia

AU - Adjei, Ohene

AU - Meyer, Christian G

AU - May, Jürgen

PY - 2006/5/1

Y1 - 2006/5/1

N2 - OBJECTIVE: To assess the prevalence and multiplicity of Plasmodium falciparum infections in Ghanaian infants.METHOD: In an epidemiological study in an area holoendemic for malaria in Ghana, the prevalence and multiplicity of P. falciparum infections (MOI) were assessed in 1069 three month-old infants by typing of the genes encoding the merozoite surface proteins 1 and 2 (msp-1, msp-2) over a recruitment period of one year. Alleles were amplified using allele family-specific polymerase chain reaction (PCR) assays and determined according to their length polymorphisms on a genetic analyzer.RESULTS: The occurrence of early infections was dependent on the season (month-stratified prevalence 6.4-29.0%). Diversity of msp-alleles was extensive and significantly higher in the dry than in the rainy season.CONCLUSIONS: The level of infection prevalence and the high multiplicity of infections (median 4, maximum 14 strains per isolate) in the first months of life indicate early contacts with parasites exhibiting a wide repertoire of antigens and, most likely, multiple infections per single mosquito bite.

AB - OBJECTIVE: To assess the prevalence and multiplicity of Plasmodium falciparum infections in Ghanaian infants.METHOD: In an epidemiological study in an area holoendemic for malaria in Ghana, the prevalence and multiplicity of P. falciparum infections (MOI) were assessed in 1069 three month-old infants by typing of the genes encoding the merozoite surface proteins 1 and 2 (msp-1, msp-2) over a recruitment period of one year. Alleles were amplified using allele family-specific polymerase chain reaction (PCR) assays and determined according to their length polymorphisms on a genetic analyzer.RESULTS: The occurrence of early infections was dependent on the season (month-stratified prevalence 6.4-29.0%). Diversity of msp-alleles was extensive and significantly higher in the dry than in the rainy season.CONCLUSIONS: The level of infection prevalence and the high multiplicity of infections (median 4, maximum 14 strains per isolate) in the first months of life indicate early contacts with parasites exhibiting a wide repertoire of antigens and, most likely, multiple infections per single mosquito bite.

KW - Animals

KW - Antigens, Protozoan

KW - Biodiversity

KW - DNA, Protozoan

KW - Endemic Diseases

KW - Genotype

KW - Ghana

KW - Humans

KW - Infant

KW - Malaria, Falciparum

KW - Merozoite Surface Protein 1

KW - Plasmodium falciparum

KW - Polymerase Chain Reaction

KW - Prevalence

KW - Protozoan Proteins

KW - Randomized Controlled Trials as Topic

KW - Seasons

U2 - 10.1111/j.1365-3156.2006.01618.x

DO - 10.1111/j.1365-3156.2006.01618.x

M3 - SCORING: Journal article

C2 - 16640613

VL - 11

SP - 613

EP - 619

JO - TROP MED INT HEALTH

JF - TROP MED INT HEALTH

SN - 1360-2276

IS - 5

ER -