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Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development

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Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development. / Skouloudaki, Kassiani; Puetz, Michael; Simons, Matias; Courbard, Jean-Remy; Boehlke, Christopher; Hartleben, Björn; Engel, Christina; Moeller, Marcus J; Englert, Christoph; Bollig, Frank; Schäfer, Tobias; Ramachandran, Haribaskar; Mlodzik, Marek; Huber, Tobias B; Kuehn, E Wolfgang; Kim, Emily; Kramer-Zucker, Albrecht; Walz, Gerd.

in: P NATL ACAD SCI USA, Jahrgang 106, Nr. 21, 26.05.2009, S. 8579-84.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Skouloudaki, K, Puetz, M, Simons, M, Courbard, J-R, Boehlke, C, Hartleben, B, Engel, C, Moeller, MJ, Englert, C, Bollig, F, Schäfer, T, Ramachandran, H, Mlodzik, M, Huber, TB, Kuehn, EW, Kim, E, Kramer-Zucker, A & Walz, G 2009, 'Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development', P NATL ACAD SCI USA, Jg. 106, Nr. 21, S. 8579-84. https://doi.org/10.1073/pnas.0811691106

APA

Skouloudaki, K., Puetz, M., Simons, M., Courbard, J-R., Boehlke, C., Hartleben, B., Engel, C., Moeller, M. J., Englert, C., Bollig, F., Schäfer, T., Ramachandran, H., Mlodzik, M., Huber, T. B., Kuehn, E. W., Kim, E., Kramer-Zucker, A., & Walz, G. (2009). Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development. P NATL ACAD SCI USA, 106(21), 8579-84. https://doi.org/10.1073/pnas.0811691106

Vancouver

Skouloudaki K, Puetz M, Simons M, Courbard J-R, Boehlke C, Hartleben B et al. Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development. P NATL ACAD SCI USA. 2009 Mai 26;106(21):8579-84. https://doi.org/10.1073/pnas.0811691106

Bibtex

@article{431a649f7c834c4daa705fad5a4befa7,
title = "Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development",
abstract = "Spatial organization of cells and their appendages is controlled by the planar cell polarity pathway, a signaling cascade initiated by the protocadherin Fat in Drosophila. Vertebrates express 4 Fat molecules, Fat1-4. We found that depletion of Fat1 caused cyst formation in the zebrafish pronephros. Knockdown of the PDZ domain containing the adaptor protein Scribble intensified the cyst-promoting phenotype of Fat1 depletion, suggesting that Fat1 and Scribble act in overlapping signaling cascades during zebrafish pronephros development. Supporting the genetic interaction with Fat1, Scribble recognized the PDZ-binding site of Fat1. Depletion of Yes-associated protein 1 (YAP1), a transcriptional co-activator inhibited by Hippo signaling, ameliorated the cyst formation in Fat1-deficient zebrafish, whereas Scribble inhibited the YAP1-induced cyst formation. Thus, reduced Hippo signaling and subsequent YAP1 disinhibition seem to play a role in the development of pronephric cysts after depletion of Fat1 or Scribble. We hypothesize that Hippo signaling is required for normal pronephros development in zebrafish and that Scribble is a candidate link between Fat and the Hippo signaling cascade in vertebrates.",
keywords = "Animals, Animals, Genetically Modified, Cadherins, Cell Line, Embryo, Nonmammalian, Humans, Kidney, Membrane Proteins, Microtubule-Associated Proteins, Promoter Regions, Genetic, Protein Binding, Protein-Serine-Threonine Kinases, Signal Transduction, Zebrafish, Zebrafish Proteins, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't",
author = "Kassiani Skouloudaki and Michael Puetz and Matias Simons and Jean-Remy Courbard and Christopher Boehlke and Bj{\"o}rn Hartleben and Christina Engel and Moeller, {Marcus J} and Christoph Englert and Frank Bollig and Tobias Sch{\"a}fer and Haribaskar Ramachandran and Marek Mlodzik and Huber, {Tobias B} and Kuehn, {E Wolfgang} and Emily Kim and Albrecht Kramer-Zucker and Gerd Walz",
year = "2009",
month = may,
day = "26",
doi = "10.1073/pnas.0811691106",
language = "English",
volume = "106",
pages = "8579--84",
journal = "P NATL ACAD SCI USA",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "21",

}

RIS

TY - JOUR

T1 - Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development

AU - Skouloudaki, Kassiani

AU - Puetz, Michael

AU - Simons, Matias

AU - Courbard, Jean-Remy

AU - Boehlke, Christopher

AU - Hartleben, Björn

AU - Engel, Christina

AU - Moeller, Marcus J

AU - Englert, Christoph

AU - Bollig, Frank

AU - Schäfer, Tobias

AU - Ramachandran, Haribaskar

AU - Mlodzik, Marek

AU - Huber, Tobias B

AU - Kuehn, E Wolfgang

AU - Kim, Emily

AU - Kramer-Zucker, Albrecht

AU - Walz, Gerd

PY - 2009/5/26

Y1 - 2009/5/26

N2 - Spatial organization of cells and their appendages is controlled by the planar cell polarity pathway, a signaling cascade initiated by the protocadherin Fat in Drosophila. Vertebrates express 4 Fat molecules, Fat1-4. We found that depletion of Fat1 caused cyst formation in the zebrafish pronephros. Knockdown of the PDZ domain containing the adaptor protein Scribble intensified the cyst-promoting phenotype of Fat1 depletion, suggesting that Fat1 and Scribble act in overlapping signaling cascades during zebrafish pronephros development. Supporting the genetic interaction with Fat1, Scribble recognized the PDZ-binding site of Fat1. Depletion of Yes-associated protein 1 (YAP1), a transcriptional co-activator inhibited by Hippo signaling, ameliorated the cyst formation in Fat1-deficient zebrafish, whereas Scribble inhibited the YAP1-induced cyst formation. Thus, reduced Hippo signaling and subsequent YAP1 disinhibition seem to play a role in the development of pronephric cysts after depletion of Fat1 or Scribble. We hypothesize that Hippo signaling is required for normal pronephros development in zebrafish and that Scribble is a candidate link between Fat and the Hippo signaling cascade in vertebrates.

AB - Spatial organization of cells and their appendages is controlled by the planar cell polarity pathway, a signaling cascade initiated by the protocadherin Fat in Drosophila. Vertebrates express 4 Fat molecules, Fat1-4. We found that depletion of Fat1 caused cyst formation in the zebrafish pronephros. Knockdown of the PDZ domain containing the adaptor protein Scribble intensified the cyst-promoting phenotype of Fat1 depletion, suggesting that Fat1 and Scribble act in overlapping signaling cascades during zebrafish pronephros development. Supporting the genetic interaction with Fat1, Scribble recognized the PDZ-binding site of Fat1. Depletion of Yes-associated protein 1 (YAP1), a transcriptional co-activator inhibited by Hippo signaling, ameliorated the cyst formation in Fat1-deficient zebrafish, whereas Scribble inhibited the YAP1-induced cyst formation. Thus, reduced Hippo signaling and subsequent YAP1 disinhibition seem to play a role in the development of pronephric cysts after depletion of Fat1 or Scribble. We hypothesize that Hippo signaling is required for normal pronephros development in zebrafish and that Scribble is a candidate link between Fat and the Hippo signaling cascade in vertebrates.

KW - Animals

KW - Animals, Genetically Modified

KW - Cadherins

KW - Cell Line

KW - Embryo, Nonmammalian

KW - Humans

KW - Kidney

KW - Membrane Proteins

KW - Microtubule-Associated Proteins

KW - Promoter Regions, Genetic

KW - Protein Binding

KW - Protein-Serine-Threonine Kinases

KW - Signal Transduction

KW - Zebrafish

KW - Zebrafish Proteins

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

U2 - 10.1073/pnas.0811691106

DO - 10.1073/pnas.0811691106

M3 - SCORING: Journal article

C2 - 19439659

VL - 106

SP - 8579

EP - 8584

JO - P NATL ACAD SCI USA

JF - P NATL ACAD SCI USA

SN - 0027-8424

IS - 21

ER -