Scanning transmission X-ray microscopy with efficient X-ray fluorescence detection (STXM-XRF) for biomedical applications in the soft and tender energy range

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Scanning transmission X-ray microscopy with efficient X-ray fluorescence detection (STXM-XRF) for biomedical applications in the soft and tender energy range. / Lühl, Lars; Andrianov, Konstantin; Dierks, Hanna; Haidl, Andreas; Dehlinger, Aurelie; Heine, Markus; Heeren, Jörg; Nisius, Thomas; Wilhein, Thomas; Kanngießer, Birgit.

in: J SYNCHROTRON RADIAT, Jahrgang 26, Nr. Pt 2, 01.03.2019, S. 430-438.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ZeitschriftenaufsatzForschungBegutachtung

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@article{664ec7ec23664ed383206f6d23de4be8,
title = "Scanning transmission X-ray microscopy with efficient X-ray fluorescence detection (STXM-XRF) for biomedical applications in the soft and tender energy range",
abstract = "Scanning transmission X-ray microscopy, especially in combination with X-ray fluorescence detection (STXM-XRF) in the soft X-ray energy range, is becoming an increasingly important tool for life sciences. Using X-ray fluorescence detection, the study of biochemical mechanisms becomes accessible. As biological matrices generally have a low fluorescence yield and thus a low fluorescence signal, high detector efficiency (e.g. large solid angle) is indispensable for avoiding long measurement times and radiation damage. Here, the new AnImaX STXM-XRF microscope equipped with a large solid angle of detection enabling fast scans and the first proof-of-principle measurements on biomedical samples are described. In addition, characterization measurements for future quantitative elemental imaging are presented.",
author = "Lars L{\"u}hl and Konstantin Andrianov and Hanna Dierks and Andreas Haidl and Aurelie Dehlinger and Markus Heine and J{\"o}rg Heeren and Thomas Nisius and Thomas Wilhein and Birgit Kanngie{\ss}er",
year = "2019",
month = mar,
day = "1",
doi = "10.1107/S1600577518016879",
language = "English",
volume = "26",
pages = "430--438",
journal = "J SYNCHROTRON RADIAT",
issn = "0909-0495",
publisher = "International Union of Crystallography",
number = "Pt 2",

}

RIS

TY - JOUR

T1 - Scanning transmission X-ray microscopy with efficient X-ray fluorescence detection (STXM-XRF) for biomedical applications in the soft and tender energy range

AU - Lühl, Lars

AU - Andrianov, Konstantin

AU - Dierks, Hanna

AU - Haidl, Andreas

AU - Dehlinger, Aurelie

AU - Heine, Markus

AU - Heeren, Jörg

AU - Nisius, Thomas

AU - Wilhein, Thomas

AU - Kanngießer, Birgit

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Scanning transmission X-ray microscopy, especially in combination with X-ray fluorescence detection (STXM-XRF) in the soft X-ray energy range, is becoming an increasingly important tool for life sciences. Using X-ray fluorescence detection, the study of biochemical mechanisms becomes accessible. As biological matrices generally have a low fluorescence yield and thus a low fluorescence signal, high detector efficiency (e.g. large solid angle) is indispensable for avoiding long measurement times and radiation damage. Here, the new AnImaX STXM-XRF microscope equipped with a large solid angle of detection enabling fast scans and the first proof-of-principle measurements on biomedical samples are described. In addition, characterization measurements for future quantitative elemental imaging are presented.

AB - Scanning transmission X-ray microscopy, especially in combination with X-ray fluorescence detection (STXM-XRF) in the soft X-ray energy range, is becoming an increasingly important tool for life sciences. Using X-ray fluorescence detection, the study of biochemical mechanisms becomes accessible. As biological matrices generally have a low fluorescence yield and thus a low fluorescence signal, high detector efficiency (e.g. large solid angle) is indispensable for avoiding long measurement times and radiation damage. Here, the new AnImaX STXM-XRF microscope equipped with a large solid angle of detection enabling fast scans and the first proof-of-principle measurements on biomedical samples are described. In addition, characterization measurements for future quantitative elemental imaging are presented.

U2 - 10.1107/S1600577518016879

DO - 10.1107/S1600577518016879

M3 - SCORING: Journal article

C2 - 30855252

VL - 26

SP - 430

EP - 438

JO - J SYNCHROTRON RADIAT

JF - J SYNCHROTRON RADIAT

SN - 0909-0495

IS - Pt 2

ER -