Scanning transmission X-ray microscopy with efficient X-ray fluorescence detection (STXM-XRF) for biomedical applications in the soft and tender energy range
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Scanning transmission X-ray microscopy with efficient X-ray fluorescence detection (STXM-XRF) for biomedical applications in the soft and tender energy range. / Lühl, Lars; Andrianov, Konstantin; Dierks, Hanna; Haidl, Andreas; Dehlinger, Aurelie; Heine, Markus; Heeren, Jörg; Nisius, Thomas; Wilhein, Thomas; Kanngießer, Birgit.
in: J SYNCHROTRON RADIAT, Jahrgang 26, Nr. Pt 2, 01.03.2019, S. 430-438.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Scanning transmission X-ray microscopy with efficient X-ray fluorescence detection (STXM-XRF) for biomedical applications in the soft and tender energy range
AU - Lühl, Lars
AU - Andrianov, Konstantin
AU - Dierks, Hanna
AU - Haidl, Andreas
AU - Dehlinger, Aurelie
AU - Heine, Markus
AU - Heeren, Jörg
AU - Nisius, Thomas
AU - Wilhein, Thomas
AU - Kanngießer, Birgit
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Scanning transmission X-ray microscopy, especially in combination with X-ray fluorescence detection (STXM-XRF) in the soft X-ray energy range, is becoming an increasingly important tool for life sciences. Using X-ray fluorescence detection, the study of biochemical mechanisms becomes accessible. As biological matrices generally have a low fluorescence yield and thus a low fluorescence signal, high detector efficiency (e.g. large solid angle) is indispensable for avoiding long measurement times and radiation damage. Here, the new AnImaX STXM-XRF microscope equipped with a large solid angle of detection enabling fast scans and the first proof-of-principle measurements on biomedical samples are described. In addition, characterization measurements for future quantitative elemental imaging are presented.
AB - Scanning transmission X-ray microscopy, especially in combination with X-ray fluorescence detection (STXM-XRF) in the soft X-ray energy range, is becoming an increasingly important tool for life sciences. Using X-ray fluorescence detection, the study of biochemical mechanisms becomes accessible. As biological matrices generally have a low fluorescence yield and thus a low fluorescence signal, high detector efficiency (e.g. large solid angle) is indispensable for avoiding long measurement times and radiation damage. Here, the new AnImaX STXM-XRF microscope equipped with a large solid angle of detection enabling fast scans and the first proof-of-principle measurements on biomedical samples are described. In addition, characterization measurements for future quantitative elemental imaging are presented.
U2 - 10.1107/S1600577518016879
DO - 10.1107/S1600577518016879
M3 - SCORING: Journal article
C2 - 30855252
VL - 26
SP - 430
EP - 438
JO - J SYNCHROTRON RADIAT
JF - J SYNCHROTRON RADIAT
SN - 0909-0495
IS - Pt 2
ER -