Sargassopenillines A-G, 6,6-spiroketals from the alga-derived fungi Penicillium thomii and Penicillium lividum
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Sargassopenillines A-G, 6,6-spiroketals from the alga-derived fungi Penicillium thomii and Penicillium lividum. / Zhuravleva, Olesya I; Sobolevskaya, Maria P; Afiyatullov, Shamil Sh; Kirichuk, Natalya N; Denisenko, Vladimir A; Dmitrenok, Pavel S; Yurchenko, Ekaterina A; Dyshlovoy, Sergey A.
in: MAR DRUGS, Jahrgang 12, Nr. 12, 12.2014, S. 5930-43.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Sargassopenillines A-G, 6,6-spiroketals from the alga-derived fungi Penicillium thomii and Penicillium lividum
AU - Zhuravleva, Olesya I
AU - Sobolevskaya, Maria P
AU - Afiyatullov, Shamil Sh
AU - Kirichuk, Natalya N
AU - Denisenko, Vladimir A
AU - Dmitrenok, Pavel S
AU - Yurchenko, Ekaterina A
AU - Dyshlovoy, Sergey A
PY - 2014/12
Y1 - 2014/12
N2 - Seven new 6,6-spiroketals, sargassopenillines A-G (1-7) were isolated from the alga-derived fungi Penicillium thomii KMM 4645 and Penicillium lividum KMM 4663. The structures of these metabolites were determined by HR-MS and 1D and 2D NMR. The absolute configurations of compounds 1, 5 and 6 were assigned by the modified Mosher's method and by CD data. Sargassopenilline C (3) inhibited the transcriptional activity of the oncogenic nuclear factor AP-1 with an IC50 value of 15 µM.
AB - Seven new 6,6-spiroketals, sargassopenillines A-G (1-7) were isolated from the alga-derived fungi Penicillium thomii KMM 4645 and Penicillium lividum KMM 4663. The structures of these metabolites were determined by HR-MS and 1D and 2D NMR. The absolute configurations of compounds 1, 5 and 6 were assigned by the modified Mosher's method and by CD data. Sargassopenilline C (3) inhibited the transcriptional activity of the oncogenic nuclear factor AP-1 with an IC50 value of 15 µM.
U2 - 10.3390/md12125930
DO - 10.3390/md12125930
M3 - SCORING: Journal article
C2 - 25501795
VL - 12
SP - 5930
EP - 5943
JO - MAR DRUGS
JF - MAR DRUGS
SN - 1660-3397
IS - 12
ER -