PortalPublikationenRsu1 regulates ethanol consumption in Drosophila and humans

Rsu1 regulates ethanol consumption in Drosophila and humans

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Rsu1 regulates ethanol consumption in Drosophila and humans. / Ojelade, Shamsideen A; Jia, Tianye; Rodan, Aylin R; Chenyang, Tao; Kadrmas, Julie L; Cattrell, Anna; Ruggeri, Barbara; Charoen, Pimphen; Lemaitre, Hervé; Banaschewski, Tobias; Büchel, Christian; Bokde, Arun L W; Carvalho, Fabiana; Conrod, Patricia J; Flor, Herta; Frouin, Vincent; Gallinat, Jürgen; Garavan, Hugh; Gowland, Penny A; Heinz, Andreas; Ittermann, Bernd; Lathrop, Mark; Lubbe, Steven; Martinot, Jean-Luc; Paus, Tomás; Smolka, Michael N; Spanagel, Rainer; O'Reilly, Paul F; Laitinen, Jaana; Veijola, Juha M; Feng, Jianfeng; Desrivières, Sylvane; Jarvelin, Marjo-Riitta; Schumann, Gunter; Rothenfluh, Adrian; IMAGEN Consortium.

in: P NATL ACAD SCI USA, Jahrgang 112, Nr. 30, 28.07.2015, S. E4085-93.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Ojelade, SA, Jia, T, Rodan, AR, Chenyang, T, Kadrmas, JL, Cattrell, A, Ruggeri, B, Charoen, P, Lemaitre, H, Banaschewski, T, Büchel, C, Bokde, ALW, Carvalho, F, Conrod, PJ, Flor, H, Frouin, V, Gallinat, J, Garavan, H, Gowland, PA, Heinz, A, Ittermann, B, Lathrop, M, Lubbe, S, Martinot, J-L, Paus, T, Smolka, MN, Spanagel, R, O'Reilly, PF, Laitinen, J, Veijola, JM, Feng, J, Desrivières, S, Jarvelin, M-R, Schumann, G, Rothenfluh, A & IMAGEN Consortium 2015, 'Rsu1 regulates ethanol consumption in Drosophila and humans', P NATL ACAD SCI USA, Jg. 112, Nr. 30, S. E4085-93. https://doi.org/10.1073/pnas.1417222112

APA

Ojelade, S. A., Jia, T., Rodan, A. R., Chenyang, T., Kadrmas, J. L., Cattrell, A., Ruggeri, B., Charoen, P., Lemaitre, H., Banaschewski, T., Büchel, C., Bokde, A. L. W., Carvalho, F., Conrod, P. J., Flor, H., Frouin, V., Gallinat, J., Garavan, H., Gowland, P. A., ... IMAGEN Consortium (2015). Rsu1 regulates ethanol consumption in Drosophila and humans. P NATL ACAD SCI USA, 112(30), E4085-93. https://doi.org/10.1073/pnas.1417222112

Vancouver

Ojelade SA, Jia T, Rodan AR, Chenyang T, Kadrmas JL, Cattrell A et al. Rsu1 regulates ethanol consumption in Drosophila and humans. P NATL ACAD SCI USA. 2015 Jul 28;112(30):E4085-93. https://doi.org/10.1073/pnas.1417222112

Bibtex

@article{89e8e6f07d8d430fa8ed9bb31de757e4,
title = "Rsu1 regulates ethanol consumption in Drosophila and humans",
abstract = "Alcohol abuse is highly prevalent, but little is understood about the molecular causes. Here, we report that Ras suppressor 1 (Rsu1) affects ethanol consumption in flies and humans. Drosophila lacking Rsu1 show reduced sensitivity to ethanol-induced sedation. We show that Rsu1 is required in the adult nervous system for normal sensitivity and that it acts downstream of the integrin cell adhesion molecule and upstream of the Ras-related C3 botulinum toxin substrate 1 (Rac1) GTPase to regulate the actin cytoskeleton. In an ethanol preference assay, global loss of Rsu1 causes high na{\"i}ve preference. In contrast, flies lacking Rsu1 only in the mushroom bodies of the brain show normal na{\"i}ve preference but then fail to acquire ethanol preference like normal flies. Rsu1 is, thus, required in distinct neurons to modulate na{\"i}ve and acquired ethanol preference. In humans, we find that polymorphisms in RSU1 are associated with brain activation in the ventral striatum during reward anticipation in adolescents and alcohol consumption in both adolescents and adults. Together, these data suggest a conserved role for integrin/Rsu1/Rac1/actin signaling in modulating reward-related phenotypes, including ethanol consumption, across phyla.",
keywords = "Actins, Adolescent, Adult, Alcohol Drinking, Animals, Brain, Cell Adhesion Molecules, Child, Cohort Studies, Cytoskeleton, Drosophila Proteins, Ethanol, Female, GTP Phosphohydrolases, Genes, Dominant, Humans, Integrins, Male, Mutation, Neurons, Polymorphism, Genetic, Questionnaires, Transcription Factors",
author = "Ojelade, {Shamsideen A} and Tianye Jia and Rodan, {Aylin R} and Tao Chenyang and Kadrmas, {Julie L} and Anna Cattrell and Barbara Ruggeri and Pimphen Charoen and Herv{\'e} Lemaitre and Tobias Banaschewski and Christian B{\"u}chel and Bokde, {Arun L W} and Fabiana Carvalho and Conrod, {Patricia J} and Herta Flor and Vincent Frouin and J{\"u}rgen Gallinat and Hugh Garavan and Gowland, {Penny A} and Andreas Heinz and Bernd Ittermann and Mark Lathrop and Steven Lubbe and Jean-Luc Martinot and Tom{\'a}s Paus and Smolka, {Michael N} and Rainer Spanagel and O'Reilly, {Paul F} and Jaana Laitinen and Veijola, {Juha M} and Jianfeng Feng and Sylvane Desrivi{\`e}res and Marjo-Riitta Jarvelin and Gunter Schumann and Adrian Rothenfluh and {IMAGEN Consortium}",
year = "2015",
month = jul,
day = "28",
doi = "10.1073/pnas.1417222112",
language = "English",
volume = "112",
pages = "E4085--93",
journal = "P NATL ACAD SCI USA",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "30",

}

RIS

TY - JOUR

T1 - Rsu1 regulates ethanol consumption in Drosophila and humans

AU - Ojelade, Shamsideen A

AU - Jia, Tianye

AU - Rodan, Aylin R

AU - Chenyang, Tao

AU - Kadrmas, Julie L

AU - Cattrell, Anna

AU - Ruggeri, Barbara

AU - Charoen, Pimphen

AU - Lemaitre, Hervé

AU - Banaschewski, Tobias

AU - Büchel, Christian

AU - Bokde, Arun L W

AU - Carvalho, Fabiana

AU - Conrod, Patricia J

AU - Flor, Herta

AU - Frouin, Vincent

AU - Gallinat, Jürgen

AU - Garavan, Hugh

AU - Gowland, Penny A

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Lathrop, Mark

AU - Lubbe, Steven

AU - Martinot, Jean-Luc

AU - Paus, Tomás

AU - Smolka, Michael N

AU - Spanagel, Rainer

AU - O'Reilly, Paul F

AU - Laitinen, Jaana

AU - Veijola, Juha M

AU - Feng, Jianfeng

AU - Desrivières, Sylvane

AU - Jarvelin, Marjo-Riitta

AU - Schumann, Gunter

AU - Rothenfluh, Adrian

AU - IMAGEN Consortium

PY - 2015/7/28

Y1 - 2015/7/28

N2 - Alcohol abuse is highly prevalent, but little is understood about the molecular causes. Here, we report that Ras suppressor 1 (Rsu1) affects ethanol consumption in flies and humans. Drosophila lacking Rsu1 show reduced sensitivity to ethanol-induced sedation. We show that Rsu1 is required in the adult nervous system for normal sensitivity and that it acts downstream of the integrin cell adhesion molecule and upstream of the Ras-related C3 botulinum toxin substrate 1 (Rac1) GTPase to regulate the actin cytoskeleton. In an ethanol preference assay, global loss of Rsu1 causes high naïve preference. In contrast, flies lacking Rsu1 only in the mushroom bodies of the brain show normal naïve preference but then fail to acquire ethanol preference like normal flies. Rsu1 is, thus, required in distinct neurons to modulate naïve and acquired ethanol preference. In humans, we find that polymorphisms in RSU1 are associated with brain activation in the ventral striatum during reward anticipation in adolescents and alcohol consumption in both adolescents and adults. Together, these data suggest a conserved role for integrin/Rsu1/Rac1/actin signaling in modulating reward-related phenotypes, including ethanol consumption, across phyla.

AB - Alcohol abuse is highly prevalent, but little is understood about the molecular causes. Here, we report that Ras suppressor 1 (Rsu1) affects ethanol consumption in flies and humans. Drosophila lacking Rsu1 show reduced sensitivity to ethanol-induced sedation. We show that Rsu1 is required in the adult nervous system for normal sensitivity and that it acts downstream of the integrin cell adhesion molecule and upstream of the Ras-related C3 botulinum toxin substrate 1 (Rac1) GTPase to regulate the actin cytoskeleton. In an ethanol preference assay, global loss of Rsu1 causes high naïve preference. In contrast, flies lacking Rsu1 only in the mushroom bodies of the brain show normal naïve preference but then fail to acquire ethanol preference like normal flies. Rsu1 is, thus, required in distinct neurons to modulate naïve and acquired ethanol preference. In humans, we find that polymorphisms in RSU1 are associated with brain activation in the ventral striatum during reward anticipation in adolescents and alcohol consumption in both adolescents and adults. Together, these data suggest a conserved role for integrin/Rsu1/Rac1/actin signaling in modulating reward-related phenotypes, including ethanol consumption, across phyla.

KW - Actins

KW - Adolescent

KW - Adult

KW - Alcohol Drinking

KW - Animals

KW - Brain

KW - Cell Adhesion Molecules

KW - Child

KW - Cohort Studies

KW - Cytoskeleton

KW - Drosophila Proteins

KW - Ethanol

KW - Female

KW - GTP Phosphohydrolases

KW - Genes, Dominant

KW - Humans

KW - Integrins

KW - Male

KW - Mutation

KW - Neurons

KW - Polymorphism, Genetic

KW - Questionnaires

KW - Transcription Factors

U2 - 10.1073/pnas.1417222112

DO - 10.1073/pnas.1417222112

M3 - SCORING: Journal article

C2 - 26170296

VL - 112

SP - E4085-93

JO - P NATL ACAD SCI USA

JF - P NATL ACAD SCI USA

SN - 0027-8424

IS - 30

ER -