PortalPublikationenRSK2 protects mice against TNF-induced bone loss

RSK2 protects mice against TNF-induced bone loss

Standard

RSK2 protects mice against TNF-induced bone loss. / Böhm, Christina; Derer, Anja; Axmann, Roland; Hillienhoff, Ulrike; Zaiss, Mario M; Luther, Julia; Zech, Christine; Stock, Michael; Scholtysek, Carina; Engelke, Klaus; Hess, Andreas; Tuckermann, Jan P; Schett, Georg; David, Jean-Pierre.

in: J CELL SCI, Jahrgang 125, Nr. Pt 9, 01.05.2012, S. 2160-71.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Böhm, C, Derer, A, Axmann, R, Hillienhoff, U, Zaiss, MM, Luther, J, Zech, C, Stock, M, Scholtysek, C, Engelke, K, Hess, A, Tuckermann, JP, Schett, G & David, J-P 2012, 'RSK2 protects mice against TNF-induced bone loss', J CELL SCI, Jg. 125, Nr. Pt 9, S. 2160-71. https://doi.org/10.1242/jcs.096008

APA

Böhm, C., Derer, A., Axmann, R., Hillienhoff, U., Zaiss, M. M., Luther, J., Zech, C., Stock, M., Scholtysek, C., Engelke, K., Hess, A., Tuckermann, J. P., Schett, G., & David, J-P. (2012). RSK2 protects mice against TNF-induced bone loss. J CELL SCI, 125(Pt 9), 2160-71. https://doi.org/10.1242/jcs.096008

Vancouver

Böhm C, Derer A, Axmann R, Hillienhoff U, Zaiss MM, Luther J et al. RSK2 protects mice against TNF-induced bone loss. J CELL SCI. 2012 Mai 1;125(Pt 9):2160-71. https://doi.org/10.1242/jcs.096008

Bibtex

@article{f0956331a5184a248ceb986a56bae51c,
title = "RSK2 protects mice against TNF-induced bone loss",
abstract = "Tumor necrosis factor (TNF)-α is a key cytokine regulator of bone and mediates inflammatory bone loss. The molecular signaling that regulates bone loss downstream of TNF-α is poorly defined. Here, we demonstrate that inactivating the pro-osteoblastogenic ERK-activated ribosomal S6 kinase RSK2 leads to a drastically accelerated and amplified systemic bone loss in mice ectopically expressing TNF-α [human TNF transgenic (hTNFtg) mice]. The phenotype is associated with a decrease in bone formation because of fewer osteoblasts as well as a drastically increased bone destruction by osteoclasts. The molecular basis of this phenotype is a cell autonomous increased sensitivity of osteoblasts and osteocytes to TNF-induced apoptosis combined with an enhancement of their osteoclast supportive activity. Thus, RSK2 exerts a strong negative regulatory loop on TNF-induced bone loss.",
keywords = "Animals, Apoptosis, Bone Resorption, Bone and Bones, Gene Expression, Humans, Male, Mice, Mice, Transgenic, Osteoblasts, Osteoclasts, Ribosomal Protein S6 Kinases, 90-kDa, Signal Transduction, Tumor Necrosis Factor-alpha",
author = "Christina B{\"o}hm and Anja Derer and Roland Axmann and Ulrike Hillienhoff and Zaiss, {Mario M} and Julia Luther and Christine Zech and Michael Stock and Carina Scholtysek and Klaus Engelke and Andreas Hess and Tuckermann, {Jan P} and Georg Schett and Jean-Pierre David",
year = "2012",
month = may,
day = "1",
doi = "10.1242/jcs.096008",
language = "English",
volume = "125",
pages = "2160--71",
journal = "J CELL SCI",
issn = "0021-9533",
publisher = "Company of Biologists Ltd",
number = "Pt 9",

}

RIS

TY - JOUR

T1 - RSK2 protects mice against TNF-induced bone loss

AU - Böhm, Christina

AU - Derer, Anja

AU - Axmann, Roland

AU - Hillienhoff, Ulrike

AU - Zaiss, Mario M

AU - Luther, Julia

AU - Zech, Christine

AU - Stock, Michael

AU - Scholtysek, Carina

AU - Engelke, Klaus

AU - Hess, Andreas

AU - Tuckermann, Jan P

AU - Schett, Georg

AU - David, Jean-Pierre

PY - 2012/5/1

Y1 - 2012/5/1

N2 - Tumor necrosis factor (TNF)-α is a key cytokine regulator of bone and mediates inflammatory bone loss. The molecular signaling that regulates bone loss downstream of TNF-α is poorly defined. Here, we demonstrate that inactivating the pro-osteoblastogenic ERK-activated ribosomal S6 kinase RSK2 leads to a drastically accelerated and amplified systemic bone loss in mice ectopically expressing TNF-α [human TNF transgenic (hTNFtg) mice]. The phenotype is associated with a decrease in bone formation because of fewer osteoblasts as well as a drastically increased bone destruction by osteoclasts. The molecular basis of this phenotype is a cell autonomous increased sensitivity of osteoblasts and osteocytes to TNF-induced apoptosis combined with an enhancement of their osteoclast supportive activity. Thus, RSK2 exerts a strong negative regulatory loop on TNF-induced bone loss.

AB - Tumor necrosis factor (TNF)-α is a key cytokine regulator of bone and mediates inflammatory bone loss. The molecular signaling that regulates bone loss downstream of TNF-α is poorly defined. Here, we demonstrate that inactivating the pro-osteoblastogenic ERK-activated ribosomal S6 kinase RSK2 leads to a drastically accelerated and amplified systemic bone loss in mice ectopically expressing TNF-α [human TNF transgenic (hTNFtg) mice]. The phenotype is associated with a decrease in bone formation because of fewer osteoblasts as well as a drastically increased bone destruction by osteoclasts. The molecular basis of this phenotype is a cell autonomous increased sensitivity of osteoblasts and osteocytes to TNF-induced apoptosis combined with an enhancement of their osteoclast supportive activity. Thus, RSK2 exerts a strong negative regulatory loop on TNF-induced bone loss.

KW - Animals

KW - Apoptosis

KW - Bone Resorption

KW - Bone and Bones

KW - Gene Expression

KW - Humans

KW - Male

KW - Mice

KW - Mice, Transgenic

KW - Osteoblasts

KW - Osteoclasts

KW - Ribosomal Protein S6 Kinases, 90-kDa

KW - Signal Transduction

KW - Tumor Necrosis Factor-alpha

U2 - 10.1242/jcs.096008

DO - 10.1242/jcs.096008

M3 - SCORING: Journal article

C2 - 22344264

VL - 125

SP - 2160

EP - 2171

JO - J CELL SCI

JF - J CELL SCI

SN - 0021-9533

IS - Pt 9

ER -