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Rs710521[A] on chromosome 3q28 close to TP63 is associated with increased urinary bladder cancer risk

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Rs710521[A] on chromosome 3q28 close to TP63 is associated with increased urinary bladder cancer risk. / Lehmann, Marie-Louise; Selinski, Silvia; Blaszkewicz, Meinolf; Orlich, Michael; Ovsiannikov, Daniel; Moormann, Oliver; Guballa, Christoph; Kress, Alexander; Truss, Michael C; Gerullis, Holger; Otto, Thomas; Barski, Dimitri; Niegisch, Günter; Albers, Peter; Frees, Sebastian; Brenner, Walburgis; Thüroff, Joachim W; Angeli-Greaves, Miriam; Seidel, Thilo; Roth, Gerhard; Dietrich, Holger; Ebbinghaus, Rainer; Prager, Hans M; Bolt, Hermann M; Falkenstein, Michael; Zimmermann, Anna; Klein, Torsten; Reckwitz, Thomas; Roemer, Hermann C; Löhlein, Dietrich; Weistenhöfer, Wobbeke; Schöps, Wolfgang; Beg, Anwer E; Aslam, Muhammad; Bánfi, Gergely; Romics, Imre; Ickstadt, Katja; Schwender, Holger; Winterpacht, Andreas; Hengstler, Jan G; Golka, Klaus.

in: ARCH TOXICOL, Jahrgang 84, Nr. 12, 12.2010, S. 967-78.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Lehmann, M-L, Selinski, S, Blaszkewicz, M, Orlich, M, Ovsiannikov, D, Moormann, O, Guballa, C, Kress, A, Truss, MC, Gerullis, H, Otto, T, Barski, D, Niegisch, G, Albers, P, Frees, S, Brenner, W, Thüroff, JW, Angeli-Greaves, M, Seidel, T, Roth, G, Dietrich, H, Ebbinghaus, R, Prager, HM, Bolt, HM, Falkenstein, M, Zimmermann, A, Klein, T, Reckwitz, T, Roemer, HC, Löhlein, D, Weistenhöfer, W, Schöps, W, Beg, AE, Aslam, M, Bánfi, G, Romics, I, Ickstadt, K, Schwender, H, Winterpacht, A, Hengstler, JG & Golka, K 2010, 'Rs710521[A] on chromosome 3q28 close to TP63 is associated with increased urinary bladder cancer risk', ARCH TOXICOL, Jg. 84, Nr. 12, S. 967-78. https://doi.org/10.1007/s00204-010-0617-6

APA

Lehmann, M-L., Selinski, S., Blaszkewicz, M., Orlich, M., Ovsiannikov, D., Moormann, O., Guballa, C., Kress, A., Truss, M. C., Gerullis, H., Otto, T., Barski, D., Niegisch, G., Albers, P., Frees, S., Brenner, W., Thüroff, J. W., Angeli-Greaves, M., Seidel, T., ... Golka, K. (2010). Rs710521[A] on chromosome 3q28 close to TP63 is associated with increased urinary bladder cancer risk. ARCH TOXICOL, 84(12), 967-78. https://doi.org/10.1007/s00204-010-0617-6

Vancouver

Lehmann M-L, Selinski S, Blaszkewicz M, Orlich M, Ovsiannikov D, Moormann O et al. Rs710521[A] on chromosome 3q28 close to TP63 is associated with increased urinary bladder cancer risk. ARCH TOXICOL. 2010 Dez;84(12):967-78. https://doi.org/10.1007/s00204-010-0617-6

Bibtex

@article{8edccbe143bc43f79f9dc6067d1a9a70,
title = "Rs710521[A] on chromosome 3q28 close to TP63 is associated with increased urinary bladder cancer risk",
abstract = "Single nucleotide polymorphism (SNP) rs710521[A], located near TP63 on chromosome 3q28, was identified to be significantly associated with increased bladder cancer risk. To investigate the association of rs710521[A] and bladder cancer by new data and by meta-analysis including all published data, rs710521 was studied in 1,425 bladder cancer cases and 1,740 controls that had not been included in previous studies. Blood samples were collected from 1995 to 2010 in Germany (n = 948/1,258), Hungary (n = 262/65), Venezuela (n = 112/190) and Pakistan (n = 103/227) supplemented by a meta-analysis of 5,695 cases and 40,187 controls. Detection of a A/G substitution (rs710521) on chromosome 3q28, position 191128627 was done via fast real-time polymerase chain reaction (rt-PCR). Rs710521[A] is associated with increased risk in the unadjusted analysis (OR = 1.21; 95% Cl = 1.04-1.40; P = 0.011) and in the recessive model adjusted for age, gender, smoking habits and ethnicity (OR = 1.23; 95% Cl = 1.05-1.44; P = 0.010). No difference between individuals occupationally exposed versus not occupationally exposed to urinary bladder carcinogens was observed concerning the relevance of rs710521[A]. Similarly, rs710521[A] did not confer different susceptibility in smokers and non-smokers. Performing a meta-analysis of 5,695 cases and 40,187 controls including all published studies on rs710521, a convincing association with bladder cancer risk was obtained (OR = 1.18; 95% Cl = 1.12-1.25; P < 0.0001). However, the odds ratio is relatively small.",
keywords = "Case-Control Studies, Chromosomes, Human, Pair 3, Female, Genes, Germany, Humans, Hungary, Male, Odds Ratio, Pakistan, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Risk, Smoking/adverse effects, Trans-Activators/genetics, Transcription Factors, Tumor Suppressor Proteins/genetics, Urinary Bladder Neoplasms/genetics, Venezuela",
author = "Marie-Louise Lehmann and Silvia Selinski and Meinolf Blaszkewicz and Michael Orlich and Daniel Ovsiannikov and Oliver Moormann and Christoph Guballa and Alexander Kress and Truss, {Michael C} and Holger Gerullis and Thomas Otto and Dimitri Barski and G{\"u}nter Niegisch and Peter Albers and Sebastian Frees and Walburgis Brenner and Th{\"u}roff, {Joachim W} and Miriam Angeli-Greaves and Thilo Seidel and Gerhard Roth and Holger Dietrich and Rainer Ebbinghaus and Prager, {Hans M} and Bolt, {Hermann M} and Michael Falkenstein and Anna Zimmermann and Torsten Klein and Thomas Reckwitz and Roemer, {Hermann C} and Dietrich L{\"o}hlein and Wobbeke Weistenh{\"o}fer and Wolfgang Sch{\"o}ps and Beg, {Anwer E} and Muhammad Aslam and Gergely B{\'a}nfi and Imre Romics and Katja Ickstadt and Holger Schwender and Andreas Winterpacht and Hengstler, {Jan G} and Klaus Golka",
year = "2010",
month = dec,
doi = "10.1007/s00204-010-0617-6",
language = "English",
volume = "84",
pages = "967--78",
journal = "ARCH TOXICOL",
issn = "0340-5761",
publisher = "Springer",
number = "12",

}

RIS

TY - JOUR

T1 - Rs710521[A] on chromosome 3q28 close to TP63 is associated with increased urinary bladder cancer risk

AU - Lehmann, Marie-Louise

AU - Selinski, Silvia

AU - Blaszkewicz, Meinolf

AU - Orlich, Michael

AU - Ovsiannikov, Daniel

AU - Moormann, Oliver

AU - Guballa, Christoph

AU - Kress, Alexander

AU - Truss, Michael C

AU - Gerullis, Holger

AU - Otto, Thomas

AU - Barski, Dimitri

AU - Niegisch, Günter

AU - Albers, Peter

AU - Frees, Sebastian

AU - Brenner, Walburgis

AU - Thüroff, Joachim W

AU - Angeli-Greaves, Miriam

AU - Seidel, Thilo

AU - Roth, Gerhard

AU - Dietrich, Holger

AU - Ebbinghaus, Rainer

AU - Prager, Hans M

AU - Bolt, Hermann M

AU - Falkenstein, Michael

AU - Zimmermann, Anna

AU - Klein, Torsten

AU - Reckwitz, Thomas

AU - Roemer, Hermann C

AU - Löhlein, Dietrich

AU - Weistenhöfer, Wobbeke

AU - Schöps, Wolfgang

AU - Beg, Anwer E

AU - Aslam, Muhammad

AU - Bánfi, Gergely

AU - Romics, Imre

AU - Ickstadt, Katja

AU - Schwender, Holger

AU - Winterpacht, Andreas

AU - Hengstler, Jan G

AU - Golka, Klaus

PY - 2010/12

Y1 - 2010/12

N2 - Single nucleotide polymorphism (SNP) rs710521[A], located near TP63 on chromosome 3q28, was identified to be significantly associated with increased bladder cancer risk. To investigate the association of rs710521[A] and bladder cancer by new data and by meta-analysis including all published data, rs710521 was studied in 1,425 bladder cancer cases and 1,740 controls that had not been included in previous studies. Blood samples were collected from 1995 to 2010 in Germany (n = 948/1,258), Hungary (n = 262/65), Venezuela (n = 112/190) and Pakistan (n = 103/227) supplemented by a meta-analysis of 5,695 cases and 40,187 controls. Detection of a A/G substitution (rs710521) on chromosome 3q28, position 191128627 was done via fast real-time polymerase chain reaction (rt-PCR). Rs710521[A] is associated with increased risk in the unadjusted analysis (OR = 1.21; 95% Cl = 1.04-1.40; P = 0.011) and in the recessive model adjusted for age, gender, smoking habits and ethnicity (OR = 1.23; 95% Cl = 1.05-1.44; P = 0.010). No difference between individuals occupationally exposed versus not occupationally exposed to urinary bladder carcinogens was observed concerning the relevance of rs710521[A]. Similarly, rs710521[A] did not confer different susceptibility in smokers and non-smokers. Performing a meta-analysis of 5,695 cases and 40,187 controls including all published studies on rs710521, a convincing association with bladder cancer risk was obtained (OR = 1.18; 95% Cl = 1.12-1.25; P < 0.0001). However, the odds ratio is relatively small.

AB - Single nucleotide polymorphism (SNP) rs710521[A], located near TP63 on chromosome 3q28, was identified to be significantly associated with increased bladder cancer risk. To investigate the association of rs710521[A] and bladder cancer by new data and by meta-analysis including all published data, rs710521 was studied in 1,425 bladder cancer cases and 1,740 controls that had not been included in previous studies. Blood samples were collected from 1995 to 2010 in Germany (n = 948/1,258), Hungary (n = 262/65), Venezuela (n = 112/190) and Pakistan (n = 103/227) supplemented by a meta-analysis of 5,695 cases and 40,187 controls. Detection of a A/G substitution (rs710521) on chromosome 3q28, position 191128627 was done via fast real-time polymerase chain reaction (rt-PCR). Rs710521[A] is associated with increased risk in the unadjusted analysis (OR = 1.21; 95% Cl = 1.04-1.40; P = 0.011) and in the recessive model adjusted for age, gender, smoking habits and ethnicity (OR = 1.23; 95% Cl = 1.05-1.44; P = 0.010). No difference between individuals occupationally exposed versus not occupationally exposed to urinary bladder carcinogens was observed concerning the relevance of rs710521[A]. Similarly, rs710521[A] did not confer different susceptibility in smokers and non-smokers. Performing a meta-analysis of 5,695 cases and 40,187 controls including all published studies on rs710521, a convincing association with bladder cancer risk was obtained (OR = 1.18; 95% Cl = 1.12-1.25; P < 0.0001). However, the odds ratio is relatively small.

KW - Case-Control Studies

KW - Chromosomes, Human, Pair 3

KW - Female

KW - Genes

KW - Germany

KW - Humans

KW - Hungary

KW - Male

KW - Odds Ratio

KW - Pakistan

KW - Polymerase Chain Reaction

KW - Polymorphism, Single Nucleotide

KW - Risk

KW - Smoking/adverse effects

KW - Trans-Activators/genetics

KW - Transcription Factors

KW - Tumor Suppressor Proteins/genetics

KW - Urinary Bladder Neoplasms/genetics

KW - Venezuela

U2 - 10.1007/s00204-010-0617-6

DO - 10.1007/s00204-010-0617-6

M3 - SCORING: Journal article

C2 - 21063684

VL - 84

SP - 967

EP - 978

JO - ARCH TOXICOL

JF - ARCH TOXICOL

SN - 0340-5761

IS - 12

ER -