rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology

Australian Ovarian Cancer Study; Ovarian Cancer Association Consortium

doi:10.3390/ijms19092473

rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology

Standard

rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology. / Australian Ovarian Cancer Study; Ovarian Cancer Association Consortium.

in: INT J MOL SCI, Jahrgang 19, Nr. 9, 21.08.2018, S. 2473.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Australian Ovarian Cancer Study & Ovarian Cancer Association Consortium 2018, 'rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology', INT J MOL SCI, Jg. 19, Nr. 9, S. 2473. https://doi.org/10.3390/ijms19092473

APA

Australian Ovarian Cancer Study, & Ovarian Cancer Association Consortium (2018). rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology. INT J MOL SCI, 19(9), 2473. https://doi.org/10.3390/ijms19092473

Vancouver

Australian Ovarian Cancer Study, Ovarian Cancer Association Consortium. rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology. INT J MOL SCI. 2018 Aug 21;19(9):2473. https://doi.org/10.3390/ijms19092473

Bibtex

@article{24b5e1cdb66a406aab8dedc089de08e1,

title = "rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology",

abstract = "Thymidylate synthase (TYMS) is a crucial enzyme for DNA synthesis. TYMS expression is regulated by its antisense mRNA, ENOSF1. Disrupted regulation may promote uncontrolled DNA synthesis and tumor growth. We sought to replicate our previously reported association between rs495139 in the TYMS-ENOSF1 3' gene region and increased risk of mucinous ovarian carcinoma (MOC) in an independent sample. Genotypes from 24,351 controls to 15,000 women with invasive OC, including 665 MOC, were available. We estimated per-allele odds ratios (OR) and 95% confidence intervals (CI) using unconditional logistic regression, and meta-analysis when combining these data with our previous report. The association between rs495139 and MOC was not significant in the independent sample (OR = 1.09; 95% CI = 0.97⁻1.22; p = 0.15; N = 665 cases). Meta-analysis suggested a weak association (OR = 1.13; 95% CI = 1.03⁻1.24; p = 0.01; N = 1019 cases). No significant association with risk of other OC histologic types was observed (p = 0.05 for tumor heterogeneity). In expression quantitative trait locus (eQTL) analysis, the rs495139 allele was positively associated with ENOSF1 mRNA expression in normal tissues of the gastrointestinal system, particularly esophageal mucosa (r = 0.51, p = 1.7 × 10-28), and nonsignificantly in five MOC tumors. The association results, along with inconclusive tumor eQTL findings, suggest that a true effect of rs495139 might be small.",

keywords = "Journal Article",

author = "Kelemen, {Linda E} and Madalene Earp and Fridley, {Brooke L} and Georgia Chenevix-Trench and Fasching, {Peter A} and Beckmann, {Matthias W} and Ekici, {Arif B} and Alexander Hein and Diether Lambrechts and Sandrina Lambrechts and {Van Nieuwenhuysen}, Els and Ignace Vergote and Rossing, {Mary Anne} and Doherty, {Jennifer A} and Jenny Chang-Claude and Sabine Behrens and Moysich, {Kirsten B} and Rikki Cannioto and Shashikant Lele and Kunle Odunsi and Goodman, {Marc T} and Shvetsov, {Yurii B} and Thompson, {Pamela J} and Wilkens, {Lynne R} and Thilo D{\"o}rk and Natalia Antonenkova and Natalia Bogdanova and Peter Hillemanns and Runnebaum, {Ingo B} and {du Bois}, Andreas and Philipp Harter and Florian Heitz and Ira Schwaab and Ralf Butzow and Pelttari, {Liisa M} and Heli Nevanlinna and Francesmary Modugno and Edwards, {Robert P} and Kelley, {Joseph L} and Ness, {Roberta B} and Karlan, {Beth Y} and Jenny Lester and Sandra Orsulic and Christine Walsh and Kjaer, {Susanne K} and Allan Jensen and Cunningham, {Julie M} and Vierkant, {Robert A} and Giles, {Graham G} and Fiona Bruinsma and Southey, {Melissa C} and Hildebrandt, {Michelle A T} and Dong Liang and Karen Lu and Xifeng Wu and Sellers, {Thomas A} and Levine, {Douglas A} and Schildkraut, {Joellen M} and Iversen, {Edwin S} and Terry, {Kathryn L} and Cramer, {Daniel W} and Tworoger, {Shelley S} and Poole, {Elizabeth M} and Bandera, {Elisa V} and Olson, {Sara H} and Irene Orlow and {Vestrheim Thomsen}, {Liv Cecilie} and Line Bjorge and Camilla Krakstad and Tangen, {Ingvild L} and Kiemeney, {Lambertus A} and Aben, {Katja K H} and Massuger, {Leon F A G} and {van Altena}, {Anne M} and Tanja Pejovic and Yukie Bean and Melissa Kellar and Cook, {Linda S} and Le, {Nhu D} and Angela Brooks-Wilson and Jacek Gronwald and Cezary Cybulski and Anna Jakubowska and Jan Lubi{\'n}ski and Nicolas Wentzensen and Brinton, {Louise A} and Jolanta Lissowska and Estrid Hogdall and Engelholm, {Svend Aage} and Claus Hogdall and Lene Lundvall and Lotte Nedergaard and Pharoah, {Paul D P} and Ed Dicks and Honglin Song and Tyrer, {Jonathan P} and Iain McNeish and Nadeem Siddiqui and Karen Carty and Rosalind Glasspool and James Paul and Campbell, {Ian G} and Diana Eccles and Whittemore, {Alice S} and Valerie McGuire and Rothstein, {Joseph H} and Weiva Sieh and Narod, {Steven A} and Phelan, {Catherine M} and McLaughlin, {John R} and Risch, {Harvey A} and Hoda Anton-Culver and Argyrios Ziogas and Usha Menon and Gayther, {Simon A} and Aleksandra Gentry-Maharaj and Ramus, {Susan J} and Wu, {Anna H} and Pearce, {Celeste Leigh} and Lee, {Alice W} and Pike, {Malcolm C} and Jolanta Kupryjanczyk and Agnieszka Podgorska and Joanna Plisiecka-Halasa and Wlodzimierz Sawicki and Goode, {Ellen L} and Andrew Berchuck and {Australian Ovarian Cancer Study} and {Ovarian Cancer Association Consortium}",

year = "2018",

month = aug,

day = "21",

doi = "10.3390/ijms19092473",

language = "English",

volume = "19",

pages = "2473",

journal = "INT J MOL SCI",

issn = "1661-6596",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "9",

}

RIS

TY - JOUR

T1 - rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology

AU - Kelemen, Linda E

AU - Earp, Madalene

AU - Fridley, Brooke L

AU - Chenevix-Trench, Georgia

AU - Fasching, Peter A

AU - Beckmann, Matthias W

AU - Ekici, Arif B

AU - Hein, Alexander

AU - Lambrechts, Diether

AU - Lambrechts, Sandrina

AU - Van Nieuwenhuysen, Els

AU - Vergote, Ignace

AU - Rossing, Mary Anne

AU - Doherty, Jennifer A

AU - Chang-Claude, Jenny

AU - Behrens, Sabine

AU - Moysich, Kirsten B

AU - Cannioto, Rikki

AU - Lele, Shashikant

AU - Odunsi, Kunle

AU - Goodman, Marc T

AU - Shvetsov, Yurii B

AU - Thompson, Pamela J

AU - Wilkens, Lynne R

AU - Dörk, Thilo

AU - Antonenkova, Natalia

AU - Bogdanova, Natalia

AU - Hillemanns, Peter

AU - Runnebaum, Ingo B

AU - du Bois, Andreas

AU - Harter, Philipp

AU - Heitz, Florian

AU - Schwaab, Ira

AU - Butzow, Ralf

AU - Pelttari, Liisa M

AU - Nevanlinna, Heli

AU - Modugno, Francesmary

AU - Edwards, Robert P

AU - Kelley, Joseph L

AU - Ness, Roberta B

AU - Karlan, Beth Y

AU - Lester, Jenny

AU - Orsulic, Sandra

AU - Walsh, Christine

AU - Kjaer, Susanne K

AU - Jensen, Allan

AU - Cunningham, Julie M

AU - Vierkant, Robert A

AU - Giles, Graham G

AU - Bruinsma, Fiona

AU - Southey, Melissa C

AU - Hildebrandt, Michelle A T

AU - Liang, Dong

AU - Lu, Karen

AU - Wu, Xifeng

AU - Sellers, Thomas A

AU - Levine, Douglas A

AU - Schildkraut, Joellen M

AU - Iversen, Edwin S

AU - Terry, Kathryn L

AU - Cramer, Daniel W

AU - Tworoger, Shelley S

AU - Poole, Elizabeth M

AU - Bandera, Elisa V

AU - Olson, Sara H

AU - Orlow, Irene

AU - Vestrheim Thomsen, Liv Cecilie

AU - Bjorge, Line

AU - Krakstad, Camilla

AU - Tangen, Ingvild L

AU - Kiemeney, Lambertus A

AU - Aben, Katja K H

AU - Massuger, Leon F A G

AU - van Altena, Anne M

AU - Pejovic, Tanja

AU - Bean, Yukie

AU - Kellar, Melissa

AU - Cook, Linda S

AU - Le, Nhu D

AU - Brooks-Wilson, Angela

AU - Gronwald, Jacek

AU - Cybulski, Cezary

AU - Jakubowska, Anna

AU - Lubiński, Jan

AU - Wentzensen, Nicolas

AU - Brinton, Louise A

AU - Lissowska, Jolanta

AU - Hogdall, Estrid

AU - Engelholm, Svend Aage

AU - Hogdall, Claus

AU - Lundvall, Lene

AU - Nedergaard, Lotte

AU - Pharoah, Paul D P

AU - Dicks, Ed

AU - Song, Honglin

AU - Tyrer, Jonathan P

AU - McNeish, Iain

AU - Siddiqui, Nadeem

AU - Carty, Karen

AU - Glasspool, Rosalind

AU - Paul, James

AU - Campbell, Ian G

AU - Eccles, Diana

AU - Whittemore, Alice S

AU - McGuire, Valerie

AU - Rothstein, Joseph H

AU - Sieh, Weiva

AU - Narod, Steven A

AU - Phelan, Catherine M

AU - McLaughlin, John R

AU - Risch, Harvey A

AU - Anton-Culver, Hoda

AU - Ziogas, Argyrios

AU - Menon, Usha

AU - Gayther, Simon A

AU - Gentry-Maharaj, Aleksandra

AU - Ramus, Susan J

AU - Wu, Anna H

AU - Pearce, Celeste Leigh

AU - Lee, Alice W

AU - Pike, Malcolm C

AU - Kupryjanczyk, Jolanta

AU - Podgorska, Agnieszka

AU - Plisiecka-Halasa, Joanna

AU - Sawicki, Wlodzimierz

AU - Goode, Ellen L

AU - Berchuck, Andrew

AU - Australian Ovarian Cancer Study

AU - Ovarian Cancer Association Consortium

PY - 2018/8/21

Y1 - 2018/8/21

N2 - Thymidylate synthase (TYMS) is a crucial enzyme for DNA synthesis. TYMS expression is regulated by its antisense mRNA, ENOSF1. Disrupted regulation may promote uncontrolled DNA synthesis and tumor growth. We sought to replicate our previously reported association between rs495139 in the TYMS-ENOSF1 3' gene region and increased risk of mucinous ovarian carcinoma (MOC) in an independent sample. Genotypes from 24,351 controls to 15,000 women with invasive OC, including 665 MOC, were available. We estimated per-allele odds ratios (OR) and 95% confidence intervals (CI) using unconditional logistic regression, and meta-analysis when combining these data with our previous report. The association between rs495139 and MOC was not significant in the independent sample (OR = 1.09; 95% CI = 0.97⁻1.22; p = 0.15; N = 665 cases). Meta-analysis suggested a weak association (OR = 1.13; 95% CI = 1.03⁻1.24; p = 0.01; N = 1019 cases). No significant association with risk of other OC histologic types was observed (p = 0.05 for tumor heterogeneity). In expression quantitative trait locus (eQTL) analysis, the rs495139 allele was positively associated with ENOSF1 mRNA expression in normal tissues of the gastrointestinal system, particularly esophageal mucosa (r = 0.51, p = 1.7 × 10-28), and nonsignificantly in five MOC tumors. The association results, along with inconclusive tumor eQTL findings, suggest that a true effect of rs495139 might be small.

AB - Thymidylate synthase (TYMS) is a crucial enzyme for DNA synthesis. TYMS expression is regulated by its antisense mRNA, ENOSF1. Disrupted regulation may promote uncontrolled DNA synthesis and tumor growth. We sought to replicate our previously reported association between rs495139 in the TYMS-ENOSF1 3' gene region and increased risk of mucinous ovarian carcinoma (MOC) in an independent sample. Genotypes from 24,351 controls to 15,000 women with invasive OC, including 665 MOC, were available. We estimated per-allele odds ratios (OR) and 95% confidence intervals (CI) using unconditional logistic regression, and meta-analysis when combining these data with our previous report. The association between rs495139 and MOC was not significant in the independent sample (OR = 1.09; 95% CI = 0.97⁻1.22; p = 0.15; N = 665 cases). Meta-analysis suggested a weak association (OR = 1.13; 95% CI = 1.03⁻1.24; p = 0.01; N = 1019 cases). No significant association with risk of other OC histologic types was observed (p = 0.05 for tumor heterogeneity). In expression quantitative trait locus (eQTL) analysis, the rs495139 allele was positively associated with ENOSF1 mRNA expression in normal tissues of the gastrointestinal system, particularly esophageal mucosa (r = 0.51, p = 1.7 × 10-28), and nonsignificantly in five MOC tumors. The association results, along with inconclusive tumor eQTL findings, suggest that a true effect of rs495139 might be small.

KW - Journal Article

U2 - 10.3390/ijms19092473

DO - 10.3390/ijms19092473

M3 - SCORING: Journal article

C2 - 30134598

VL - 19

SP - 2473

JO - INT J MOL SCI

JF - INT J MOL SCI

SN - 1661-6596

IS - 9

ER -