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Role of systemic immune-inflammation index in patients treated with salvage radical prostatectomy

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Role of systemic immune-inflammation index in patients treated with salvage radical prostatectomy. / Rajwa, Pawel; Schuettfort, Victor M; Quhal, Fahad; Mori, Keiichiro; Katayama, Satoshi; Laukhtina, Ekaterina; Pradere, Benjamin; Motlagh, Reza Sari; Mostafaei, Hadi; Grossmann, Nico C; Aulitzky, Andreas; Paradysz, Andrzej; Karakiewicz, Pierre I; Fajkovic, Harun; Zimmermann, Kristin; Heidenreich, Axel; Gontero, Paolo; Shariat, Shahrokh F.

in: WORLD J UROL, Jahrgang 39, Nr. 10, 10.2021, S. 3771-3779.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Rajwa, P, Schuettfort, VM, Quhal, F, Mori, K, Katayama, S, Laukhtina, E, Pradere, B, Motlagh, RS, Mostafaei, H, Grossmann, NC, Aulitzky, A, Paradysz, A, Karakiewicz, PI, Fajkovic, H, Zimmermann, K, Heidenreich, A, Gontero, P & Shariat, SF 2021, 'Role of systemic immune-inflammation index in patients treated with salvage radical prostatectomy', WORLD J UROL, Jg. 39, Nr. 10, S. 3771-3779. https://doi.org/10.1007/s00345-021-03715-4

APA

Rajwa, P., Schuettfort, V. M., Quhal, F., Mori, K., Katayama, S., Laukhtina, E., Pradere, B., Motlagh, R. S., Mostafaei, H., Grossmann, N. C., Aulitzky, A., Paradysz, A., Karakiewicz, P. I., Fajkovic, H., Zimmermann, K., Heidenreich, A., Gontero, P., & Shariat, S. F. (2021). Role of systemic immune-inflammation index in patients treated with salvage radical prostatectomy. WORLD J UROL, 39(10), 3771-3779. https://doi.org/10.1007/s00345-021-03715-4

Vancouver

Rajwa P, Schuettfort VM, Quhal F, Mori K, Katayama S, Laukhtina E et al. Role of systemic immune-inflammation index in patients treated with salvage radical prostatectomy. WORLD J UROL. 2021 Okt;39(10):3771-3779. https://doi.org/10.1007/s00345-021-03715-4

Bibtex

@article{0c6f7d71290440f4881cf00266950335,
title = "Role of systemic immune-inflammation index in patients treated with salvage radical prostatectomy",
abstract = "PURPOSE: To examine the predictive and prognostic value of preoperative Systemic Immune-inflammation Index (SII) in patients with radio-recurrent prostate cancer (PCa) treated with salvage radical prostatectomy (SRP).MATERIALS AND METHODS: This multicenter retrospective study included 214 patients with radio-recurrent PCa, treated with SRP between 2007 and 2015. SII was measured preoperatively (neutrophils × platelets/lymphocytes) and the cohort was stratified using optimal cut-off. Uni- and multivariable logistic and Cox regression analyses were performed to evaluate the predictive and prognostic value of SII as a preoperative biomarker.RESULTS: A total of 81 patients had high preoperative SII (≥ 730). On multivariable logistic regression modeling, high SII was predictive for lymph node metastases (OR 3.32, 95% CI 1.45-7.90, p = 0.005), and non-organ confined disease (OR 2.55, 95% CI 1.33-4.97, p = 0.005). In preoperative regression analysis, high preoperative SII was an independent prognostic factor for cancer-specific survival (CSS; HR 10.7, 95% CI 1.12-103, p = 0.039) and overall survival (OS; HR 8.57, 95% CI 2.70-27.2, p < 0.001). Similarly, in postoperative multivariable models, SII was associated with worse CSS (HR 22.11, 95% CI 1.23-398.12, p = 0.036) and OS (HR 5.98, 95% CI 1.67-21.44, p = 0.006). Notably, the addition of SII to preoperative reference models improved the C-index for the prognosis of CSS (89.5 vs. 80.5) and OS (85.1 vs 77.1).CONCLUSIONS: In radio-recurrent PCa patients, high SII was associated with adverse pathological features at SRP and survival after SRP. Preoperative SII could help identify patients who might benefit from novel imaging modalities, multimodal therapy or a closer posttreatment surveillance.",
author = "Pawel Rajwa and Schuettfort, {Victor M} and Fahad Quhal and Keiichiro Mori and Satoshi Katayama and Ekaterina Laukhtina and Benjamin Pradere and Motlagh, {Reza Sari} and Hadi Mostafaei and Grossmann, {Nico C} and Andreas Aulitzky and Andrzej Paradysz and Karakiewicz, {Pierre I} and Harun Fajkovic and Kristin Zimmermann and Axel Heidenreich and Paolo Gontero and Shariat, {Shahrokh F}",
note = "{\textcopyright} 2021. The Author(s).",
year = "2021",
month = oct,
doi = "10.1007/s00345-021-03715-4",
language = "English",
volume = "39",
pages = "3771--3779",
journal = "WORLD J UROL",
issn = "0724-4983",
publisher = "Springer",
number = "10",

}

RIS

TY - JOUR

T1 - Role of systemic immune-inflammation index in patients treated with salvage radical prostatectomy

AU - Rajwa, Pawel

AU - Schuettfort, Victor M

AU - Quhal, Fahad

AU - Mori, Keiichiro

AU - Katayama, Satoshi

AU - Laukhtina, Ekaterina

AU - Pradere, Benjamin

AU - Motlagh, Reza Sari

AU - Mostafaei, Hadi

AU - Grossmann, Nico C

AU - Aulitzky, Andreas

AU - Paradysz, Andrzej

AU - Karakiewicz, Pierre I

AU - Fajkovic, Harun

AU - Zimmermann, Kristin

AU - Heidenreich, Axel

AU - Gontero, Paolo

AU - Shariat, Shahrokh F

N1 - © 2021. The Author(s).

PY - 2021/10

Y1 - 2021/10

N2 - PURPOSE: To examine the predictive and prognostic value of preoperative Systemic Immune-inflammation Index (SII) in patients with radio-recurrent prostate cancer (PCa) treated with salvage radical prostatectomy (SRP).MATERIALS AND METHODS: This multicenter retrospective study included 214 patients with radio-recurrent PCa, treated with SRP between 2007 and 2015. SII was measured preoperatively (neutrophils × platelets/lymphocytes) and the cohort was stratified using optimal cut-off. Uni- and multivariable logistic and Cox regression analyses were performed to evaluate the predictive and prognostic value of SII as a preoperative biomarker.RESULTS: A total of 81 patients had high preoperative SII (≥ 730). On multivariable logistic regression modeling, high SII was predictive for lymph node metastases (OR 3.32, 95% CI 1.45-7.90, p = 0.005), and non-organ confined disease (OR 2.55, 95% CI 1.33-4.97, p = 0.005). In preoperative regression analysis, high preoperative SII was an independent prognostic factor for cancer-specific survival (CSS; HR 10.7, 95% CI 1.12-103, p = 0.039) and overall survival (OS; HR 8.57, 95% CI 2.70-27.2, p < 0.001). Similarly, in postoperative multivariable models, SII was associated with worse CSS (HR 22.11, 95% CI 1.23-398.12, p = 0.036) and OS (HR 5.98, 95% CI 1.67-21.44, p = 0.006). Notably, the addition of SII to preoperative reference models improved the C-index for the prognosis of CSS (89.5 vs. 80.5) and OS (85.1 vs 77.1).CONCLUSIONS: In radio-recurrent PCa patients, high SII was associated with adverse pathological features at SRP and survival after SRP. Preoperative SII could help identify patients who might benefit from novel imaging modalities, multimodal therapy or a closer posttreatment surveillance.

AB - PURPOSE: To examine the predictive and prognostic value of preoperative Systemic Immune-inflammation Index (SII) in patients with radio-recurrent prostate cancer (PCa) treated with salvage radical prostatectomy (SRP).MATERIALS AND METHODS: This multicenter retrospective study included 214 patients with radio-recurrent PCa, treated with SRP between 2007 and 2015. SII was measured preoperatively (neutrophils × platelets/lymphocytes) and the cohort was stratified using optimal cut-off. Uni- and multivariable logistic and Cox regression analyses were performed to evaluate the predictive and prognostic value of SII as a preoperative biomarker.RESULTS: A total of 81 patients had high preoperative SII (≥ 730). On multivariable logistic regression modeling, high SII was predictive for lymph node metastases (OR 3.32, 95% CI 1.45-7.90, p = 0.005), and non-organ confined disease (OR 2.55, 95% CI 1.33-4.97, p = 0.005). In preoperative regression analysis, high preoperative SII was an independent prognostic factor for cancer-specific survival (CSS; HR 10.7, 95% CI 1.12-103, p = 0.039) and overall survival (OS; HR 8.57, 95% CI 2.70-27.2, p < 0.001). Similarly, in postoperative multivariable models, SII was associated with worse CSS (HR 22.11, 95% CI 1.23-398.12, p = 0.036) and OS (HR 5.98, 95% CI 1.67-21.44, p = 0.006). Notably, the addition of SII to preoperative reference models improved the C-index for the prognosis of CSS (89.5 vs. 80.5) and OS (85.1 vs 77.1).CONCLUSIONS: In radio-recurrent PCa patients, high SII was associated with adverse pathological features at SRP and survival after SRP. Preoperative SII could help identify patients who might benefit from novel imaging modalities, multimodal therapy or a closer posttreatment surveillance.

U2 - 10.1007/s00345-021-03715-4

DO - 10.1007/s00345-021-03715-4

M3 - SCORING: Journal article

C2 - 33997919

VL - 39

SP - 3771

EP - 3779

JO - WORLD J UROL

JF - WORLD J UROL

SN - 0724-4983

IS - 10

ER -