Role of stress system disturbance and enhanced novelty response in spatial learning of NCAM-deficient mice
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Role of stress system disturbance and enhanced novelty response in spatial learning of NCAM-deficient mice. / Brandewiede, Joerg; Jakovcevski, Mira; Stork, Oliver; Schachner, Melitta.
in: STRESS, Jahrgang 16, Nr. 6, 01.11.2013, S. 638-46.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Role of stress system disturbance and enhanced novelty response in spatial learning of NCAM-deficient mice
AU - Brandewiede, Joerg
AU - Jakovcevski, Mira
AU - Stork, Oliver
AU - Schachner, Melitta
PY - 2013/11/1
Y1 - 2013/11/1
N2 - The neural cell adhesion molecule (NCAM) plays a crucial role in stress-related brain function, emotional behavior and memory formation. In this study, we investigated the functions of the glucocorticoid and serotonergic systems in mice constitutively deficient for NCAM (NCAM-/- mice). Our data provide evidence for a hyperfunction of the hypothalamic-pituitary-adrenal axis, with enlarged adrenal glands and increased stress-induced corticosterone release, but reduced hippocampal glucocorticoid receptor expression in NCAM-/- mice when compared to NCAM+/+ mice. We also obtained evidence for a hypofunction of 5-HT1A autoreceptors as indicated by increased 8-0H-DPAT-induced hypothermia. These findings suggest a disturbance of both humoral and neural stress systems in NCAM-/- mice. Accordingly, we not only confirmed previously observed hyperarousal of NCAM-/- mice in various anxiety tests, but also observed an increased response to novelty exposure in these animals. Spatial learning deficits of the NCAM-/- mice in a Morris Water maze persisted, even when mice were pretrained to prevent effects of novelty or stress. We suggest that NCAM-mediated processes are involved in both novelty/stress-related emotional behavior and in cognitive function during spatial learning.
AB - The neural cell adhesion molecule (NCAM) plays a crucial role in stress-related brain function, emotional behavior and memory formation. In this study, we investigated the functions of the glucocorticoid and serotonergic systems in mice constitutively deficient for NCAM (NCAM-/- mice). Our data provide evidence for a hyperfunction of the hypothalamic-pituitary-adrenal axis, with enlarged adrenal glands and increased stress-induced corticosterone release, but reduced hippocampal glucocorticoid receptor expression in NCAM-/- mice when compared to NCAM+/+ mice. We also obtained evidence for a hypofunction of 5-HT1A autoreceptors as indicated by increased 8-0H-DPAT-induced hypothermia. These findings suggest a disturbance of both humoral and neural stress systems in NCAM-/- mice. Accordingly, we not only confirmed previously observed hyperarousal of NCAM-/- mice in various anxiety tests, but also observed an increased response to novelty exposure in these animals. Spatial learning deficits of the NCAM-/- mice in a Morris Water maze persisted, even when mice were pretrained to prevent effects of novelty or stress. We suggest that NCAM-mediated processes are involved in both novelty/stress-related emotional behavior and in cognitive function during spatial learning.
KW - 8-Hydroxy-2-(di-n-propylamino)tetralin
KW - Animals
KW - Anxiety
KW - Corticosterone
KW - Hippocampus
KW - Hypothalamo-Hypophyseal System
KW - Hypothermia
KW - Maze Learning
KW - Memory, Short-Term
KW - Mice
KW - Motor Activity
KW - Neural Cell Adhesion Molecules
KW - Pituitary-Adrenal System
KW - Receptors, Glucocorticoid
KW - Stress, Psychological
U2 - 10.3109/10253890.2013.840773
DO - 10.3109/10253890.2013.840773
M3 - SCORING: Journal article
C2 - 24000815
VL - 16
SP - 638
EP - 646
JO - STRESS
JF - STRESS
SN - 1025-3890
IS - 6
ER -
