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Role of CCR2 in inflammatory conditions of the central nervous system

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Role of CCR2 in inflammatory conditions of the central nervous system. / Chu, Hannah X; Arumugam, Thiruma V; Gelderblom, Mathias; Magnus, Tim; Drummond, Grant R; Sobey, Christopher G.

in: J CEREBR BLOOD F MET, Jahrgang 34, Nr. 9, 01.09.2014, S. 1425-9.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Chu, HX, Arumugam, TV, Gelderblom, M, Magnus, T, Drummond, GR & Sobey, CG 2014, 'Role of CCR2 in inflammatory conditions of the central nervous system', J CEREBR BLOOD F MET, Jg. 34, Nr. 9, S. 1425-9. https://doi.org/10.1038/jcbfm.2014.120

APA

Chu, H. X., Arumugam, T. V., Gelderblom, M., Magnus, T., Drummond, G. R., & Sobey, C. G. (2014). Role of CCR2 in inflammatory conditions of the central nervous system. J CEREBR BLOOD F MET, 34(9), 1425-9. https://doi.org/10.1038/jcbfm.2014.120

Vancouver

Chu HX, Arumugam TV, Gelderblom M, Magnus T, Drummond GR, Sobey CG. Role of CCR2 in inflammatory conditions of the central nervous system. J CEREBR BLOOD F MET. 2014 Sep 1;34(9):1425-9. https://doi.org/10.1038/jcbfm.2014.120

Bibtex

@article{985c9ec74ae24a53a0766b11c3926a92,
title = "Role of CCR2 in inflammatory conditions of the central nervous system",
abstract = "CC chemokine receptor 2 (CCR2) plays important roles in extravasation and transmigration of monocytes under inflammatory conditions. CCR2 and its ligands have been extensively studied in a range of inflammatory diseases in the central nervous system (CNS), including multiple sclerosis, Alzheimer's disease and ischemic stroke. This brief review summarizes our current understanding of the physiologic and pathologic roles of CCR2, focusing on its involvement in CNS inflammatory diseases. There appears to be a rationale for exploring therapies involving CCR2 inhibition in multiple sclerosis and ischemic stroke, but there is also evidence for immunomodulatory and protective effects of CCR2 activity during CNS inflammation. The critical balance between protective and detrimental roles of CCR2-dependent recruitment of leukocytes must therefore be carefully examined to guide safe and effective development of any therapies involving CCR2 modulation.",
keywords = "Animals, Brain Diseases, Humans, Monocytes, Multiple Sclerosis, Receptors, CCR2, Transendothelial and Transepithelial Migration",
author = "Chu, {Hannah X} and Arumugam, {Thiruma V} and Mathias Gelderblom and Tim Magnus and Drummond, {Grant R} and Sobey, {Christopher G}",
year = "2014",
month = sep,
day = "1",
doi = "10.1038/jcbfm.2014.120",
language = "English",
volume = "34",
pages = "1425--9",
journal = "J CEREBR BLOOD F MET",
issn = "0271-678X",
publisher = "SAGE Publications",
number = "9",

}

RIS

TY - JOUR

T1 - Role of CCR2 in inflammatory conditions of the central nervous system

AU - Chu, Hannah X

AU - Arumugam, Thiruma V

AU - Gelderblom, Mathias

AU - Magnus, Tim

AU - Drummond, Grant R

AU - Sobey, Christopher G

PY - 2014/9/1

Y1 - 2014/9/1

N2 - CC chemokine receptor 2 (CCR2) plays important roles in extravasation and transmigration of monocytes under inflammatory conditions. CCR2 and its ligands have been extensively studied in a range of inflammatory diseases in the central nervous system (CNS), including multiple sclerosis, Alzheimer's disease and ischemic stroke. This brief review summarizes our current understanding of the physiologic and pathologic roles of CCR2, focusing on its involvement in CNS inflammatory diseases. There appears to be a rationale for exploring therapies involving CCR2 inhibition in multiple sclerosis and ischemic stroke, but there is also evidence for immunomodulatory and protective effects of CCR2 activity during CNS inflammation. The critical balance between protective and detrimental roles of CCR2-dependent recruitment of leukocytes must therefore be carefully examined to guide safe and effective development of any therapies involving CCR2 modulation.

AB - CC chemokine receptor 2 (CCR2) plays important roles in extravasation and transmigration of monocytes under inflammatory conditions. CCR2 and its ligands have been extensively studied in a range of inflammatory diseases in the central nervous system (CNS), including multiple sclerosis, Alzheimer's disease and ischemic stroke. This brief review summarizes our current understanding of the physiologic and pathologic roles of CCR2, focusing on its involvement in CNS inflammatory diseases. There appears to be a rationale for exploring therapies involving CCR2 inhibition in multiple sclerosis and ischemic stroke, but there is also evidence for immunomodulatory and protective effects of CCR2 activity during CNS inflammation. The critical balance between protective and detrimental roles of CCR2-dependent recruitment of leukocytes must therefore be carefully examined to guide safe and effective development of any therapies involving CCR2 modulation.

KW - Animals

KW - Brain Diseases

KW - Humans

KW - Monocytes

KW - Multiple Sclerosis

KW - Receptors, CCR2

KW - Transendothelial and Transepithelial Migration

U2 - 10.1038/jcbfm.2014.120

DO - 10.1038/jcbfm.2014.120

M3 - SCORING: Journal article

C2 - 24984897

VL - 34

SP - 1425

EP - 1429

JO - J CEREBR BLOOD F MET

JF - J CEREBR BLOOD F MET

SN - 0271-678X

IS - 9

ER -