Role and mechanism of BMP4 in bone, craniofacial, and tooth development
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Role and mechanism of BMP4 in bone, craniofacial, and tooth development. / Ye, Yuer; Jiang, Zhiwei; Pan, Yiqi; Yang, Guoli; Wang, Ying.
in: ARCH ORAL BIOL, Jahrgang 140, 105465, 08.2022.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Role and mechanism of BMP4 in bone, craniofacial, and tooth development
AU - Ye, Yuer
AU - Jiang, Zhiwei
AU - Pan, Yiqi
AU - Yang, Guoli
AU - Wang, Ying
N1 - Copyright © 2022 Elsevier Ltd. All rights reserved.
PY - 2022/8
Y1 - 2022/8
N2 - OBJECTIVE: This review aimed to present an overview of the effect of bone morphogenetic protein 4 (BMP4) on craniofacial and skeletal development, particularly the specific role of BMP4 in tooth development.DESIGN: The search for this narrative review was conducted in PubMed, Web of Science, Embase, and ScienceDirect using relevant keywords, including checking reference lists of journal articles by hand searching.RESULTS: Mutations or deletions of BMP4 cause tissue development defects in mice and humans, such as fragile bone, craniofacial deformity, cleft lip and palate, tooth development stagnation, and abnormal structure.CONCLUSIONS: BMP4 is a reliable and vital candidate to regulate the development of bones, craniofacies, and teeth. It also has high clinical application potential.
AB - OBJECTIVE: This review aimed to present an overview of the effect of bone morphogenetic protein 4 (BMP4) on craniofacial and skeletal development, particularly the specific role of BMP4 in tooth development.DESIGN: The search for this narrative review was conducted in PubMed, Web of Science, Embase, and ScienceDirect using relevant keywords, including checking reference lists of journal articles by hand searching.RESULTS: Mutations or deletions of BMP4 cause tissue development defects in mice and humans, such as fragile bone, craniofacial deformity, cleft lip and palate, tooth development stagnation, and abnormal structure.CONCLUSIONS: BMP4 is a reliable and vital candidate to regulate the development of bones, craniofacies, and teeth. It also has high clinical application potential.
KW - Animals
KW - Bone Morphogenetic Protein 4/genetics
KW - Cleft Lip/genetics
KW - Cleft Palate/genetics
KW - Mice
KW - Odontogenesis/genetics
KW - Tooth
U2 - 10.1016/j.archoralbio.2022.105465
DO - 10.1016/j.archoralbio.2022.105465
M3 - SCORING: Review article
C2 - 35662681
VL - 140
JO - ARCH ORAL BIOL
JF - ARCH ORAL BIOL
SN - 0003-9969
M1 - 105465
ER -