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Risk factors for excessively prolonged meropenem use in the intensive care settinga case-contol study

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Risk factors for excessively prolonged meropenem use in the intensive care settinga case-contol study. / Katchanov, Juri; Kreuels, Benno; Maurer, Florian P; Wöstmann, Kai ; Jochum, Johannes; König, Christina; Seoudy, Kariem; Rohde, Holger; Lohse, Ansgar W; Wichmann, Dominic; Baehr, Michael; Rothe, Camilla; Kluge, Stefan.

in: BMC INFECT DIS, Jahrgang 17, Nr. 1, 08.02.2017, S. 131.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Katchanov, J, Kreuels, B, Maurer, FP, Wöstmann, K, Jochum, J, König, C, Seoudy, K, Rohde, H, Lohse, AW, Wichmann, D, Baehr, M, Rothe, C & Kluge, S 2017, 'Risk factors for excessively prolonged meropenem use in the intensive care settinga case-contol study', BMC INFECT DIS, Jg. 17, Nr. 1, S. 131. https://doi.org/10.1186/s12879-017-2229-8

APA

Katchanov, J., Kreuels, B., Maurer, F. P., Wöstmann, K., Jochum, J., König, C., Seoudy, K., Rohde, H., Lohse, A. W., Wichmann, D., Baehr, M., Rothe, C., & Kluge, S. (2017). Risk factors for excessively prolonged meropenem use in the intensive care settinga case-contol study. BMC INFECT DIS, 17(1), 131. https://doi.org/10.1186/s12879-017-2229-8

Vancouver

Katchanov J, Kreuels B, Maurer FP, Wöstmann K, Jochum J, König C et al. Risk factors for excessively prolonged meropenem use in the intensive care settinga case-contol study. BMC INFECT DIS. 2017 Feb 8;17(1):131. https://doi.org/10.1186/s12879-017-2229-8

Bibtex

@article{448b1d7dc4ed4e62849145680b28b802,
title = "Risk factors for excessively prolonged meropenem use in the intensive care settinga case-contol study",
abstract = "BACKGROUND: Inappropriate use of broad-spectrum antimicrobials affects adversely both the individual patient and the general public. The aim of the study was to identify patients at risk for excessively prolonged carbapenem treatment in the ICU as a target for antimicrobial stewardship interventions.METHODS: Case-control study in a network of 11 ICUs of a university hospital. Patients with uninterrupted meropenem therapy (MT) > 4 weeks were compared to controls. Controls were defined as patients who stayed on the ICU > 4 weeks and received meropenem for ≤ 2 weeks. Associations between case-control status and potential risk factors were determined in a multivariate logistic regression model.RESULTS: Between 1(st) of January 2013 and 31(st) of December 2015, we identified 36 patients with uninterrupted MT > 4 weeks. Patients with prolonged MT were more likely to be surgical patients (72.2% of cases vs. 31.5% of controls; p ≤ 0.001) with peritonitis being the most common infection (n = 16, 44.4%). In the multivariate logistic regression model colonization with multidrug-resistant (MDR) Gram-negative bacteria (OR 7.52; 95% CI 1.88-30.14, p = 0.004) and the type of infection (peritonitis vs. pneumonia: OR 16.96, 95% CI 2.95-97.49) were associated with prolonged MT.CONCLUSION: Surgical patients with peritonitis and patients with known colonization with MDR Gram-negative bacteria are at risk for excessively prolonged carbapenem therapy and represent an important target population for antimicrobial stewardship interventions.",
author = "Juri Katchanov and Benno Kreuels and Maurer, {Florian P} and Kai W{\"o}stmann and Johannes Jochum and Christina K{\"o}nig and Kariem Seoudy and Holger Rohde and Lohse, {Ansgar W} and Dominic Wichmann and Michael Baehr and Camilla Rothe and Stefan Kluge",
year = "2017",
month = feb,
day = "8",
doi = "10.1186/s12879-017-2229-8",
language = "English",
volume = "17",
pages = "131",
journal = "BMC INFECT DIS",
issn = "1471-2334",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Risk factors for excessively prolonged meropenem use in the intensive care settinga case-contol study

AU - Katchanov, Juri

AU - Kreuels, Benno

AU - Maurer, Florian P

AU - Wöstmann, Kai

AU - Jochum, Johannes

AU - König, Christina

AU - Seoudy, Kariem

AU - Rohde, Holger

AU - Lohse, Ansgar W

AU - Wichmann, Dominic

AU - Baehr, Michael

AU - Rothe, Camilla

AU - Kluge, Stefan

PY - 2017/2/8

Y1 - 2017/2/8

N2 - BACKGROUND: Inappropriate use of broad-spectrum antimicrobials affects adversely both the individual patient and the general public. The aim of the study was to identify patients at risk for excessively prolonged carbapenem treatment in the ICU as a target for antimicrobial stewardship interventions.METHODS: Case-control study in a network of 11 ICUs of a university hospital. Patients with uninterrupted meropenem therapy (MT) > 4 weeks were compared to controls. Controls were defined as patients who stayed on the ICU > 4 weeks and received meropenem for ≤ 2 weeks. Associations between case-control status and potential risk factors were determined in a multivariate logistic regression model.RESULTS: Between 1(st) of January 2013 and 31(st) of December 2015, we identified 36 patients with uninterrupted MT > 4 weeks. Patients with prolonged MT were more likely to be surgical patients (72.2% of cases vs. 31.5% of controls; p ≤ 0.001) with peritonitis being the most common infection (n = 16, 44.4%). In the multivariate logistic regression model colonization with multidrug-resistant (MDR) Gram-negative bacteria (OR 7.52; 95% CI 1.88-30.14, p = 0.004) and the type of infection (peritonitis vs. pneumonia: OR 16.96, 95% CI 2.95-97.49) were associated with prolonged MT.CONCLUSION: Surgical patients with peritonitis and patients with known colonization with MDR Gram-negative bacteria are at risk for excessively prolonged carbapenem therapy and represent an important target population for antimicrobial stewardship interventions.

AB - BACKGROUND: Inappropriate use of broad-spectrum antimicrobials affects adversely both the individual patient and the general public. The aim of the study was to identify patients at risk for excessively prolonged carbapenem treatment in the ICU as a target for antimicrobial stewardship interventions.METHODS: Case-control study in a network of 11 ICUs of a university hospital. Patients with uninterrupted meropenem therapy (MT) > 4 weeks were compared to controls. Controls were defined as patients who stayed on the ICU > 4 weeks and received meropenem for ≤ 2 weeks. Associations between case-control status and potential risk factors were determined in a multivariate logistic regression model.RESULTS: Between 1(st) of January 2013 and 31(st) of December 2015, we identified 36 patients with uninterrupted MT > 4 weeks. Patients with prolonged MT were more likely to be surgical patients (72.2% of cases vs. 31.5% of controls; p ≤ 0.001) with peritonitis being the most common infection (n = 16, 44.4%). In the multivariate logistic regression model colonization with multidrug-resistant (MDR) Gram-negative bacteria (OR 7.52; 95% CI 1.88-30.14, p = 0.004) and the type of infection (peritonitis vs. pneumonia: OR 16.96, 95% CI 2.95-97.49) were associated with prolonged MT.CONCLUSION: Surgical patients with peritonitis and patients with known colonization with MDR Gram-negative bacteria are at risk for excessively prolonged carbapenem therapy and represent an important target population for antimicrobial stewardship interventions.

U2 - 10.1186/s12879-017-2229-8

DO - 10.1186/s12879-017-2229-8

M3 - SCORING: Journal article

C2 - 28178922

VL - 17

SP - 131

JO - BMC INFECT DIS

JF - BMC INFECT DIS

SN - 1471-2334

IS - 1

ER -