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Risk and timing of biochemical recurrence in pT3aN0/Nx prostate cancer with positive surgical margin - A multicenter study

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Risk and timing of biochemical recurrence in pT3aN0/Nx prostate cancer with positive surgical margin - A multicenter study. / Karl, Alexander; Buchner, Alexander; Tympner, Christiane; Kirchner, Thomas; Ganswindt, Ute; Belka, Claus; Ganzer, Roman; Wieland, Wolf; Eder, Fabian; Hofstädter, Ferdinand; Schilling, David; Sievert, Karl-Dietrich; Stenzl, Arnulf; Scharpf, Marcus; Fend, Falko; Vom Dorp, Frank; Rübben, Herbert; Kurt Werner, Schmid; Porres-Knoblauch, Daniel; Heidenreich, Axel; Hangarter, Birgit; Knüchel-Clarke, Ruth; Rogenhofer, Michael; Wullich, Bernd; Hartmann, Arndt; Comploj, Evi; Pycha, Armin; Hanspeter, Esther; Pehrke, Dirk; Sauter, Guido; Graefen, Markus; Gratzke, Christian; Stief, Christian; Wiegel, Thomas; Haese, Alexander.

in: RADIOTHER ONCOL, Jahrgang 116, Nr. 1, 07.2015, S. 119-24.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Karl, A, Buchner, A, Tympner, C, Kirchner, T, Ganswindt, U, Belka, C, Ganzer, R, Wieland, W, Eder, F, Hofstädter, F, Schilling, D, Sievert, K-D, Stenzl, A, Scharpf, M, Fend, F, Vom Dorp, F, Rübben, H, Kurt Werner, S, Porres-Knoblauch, D, Heidenreich, A, Hangarter, B, Knüchel-Clarke, R, Rogenhofer, M, Wullich, B, Hartmann, A, Comploj, E, Pycha, A, Hanspeter, E, Pehrke, D, Sauter, G, Graefen, M, Gratzke, C, Stief, C, Wiegel, T & Haese, A 2015, 'Risk and timing of biochemical recurrence in pT3aN0/Nx prostate cancer with positive surgical margin - A multicenter study', RADIOTHER ONCOL, Jg. 116, Nr. 1, S. 119-24. https://doi.org/10.1016/j.radonc.2015.06.021

APA

Karl, A., Buchner, A., Tympner, C., Kirchner, T., Ganswindt, U., Belka, C., Ganzer, R., Wieland, W., Eder, F., Hofstädter, F., Schilling, D., Sievert, K-D., Stenzl, A., Scharpf, M., Fend, F., Vom Dorp, F., Rübben, H., Kurt Werner, S., Porres-Knoblauch, D., ... Haese, A. (2015). Risk and timing of biochemical recurrence in pT3aN0/Nx prostate cancer with positive surgical margin - A multicenter study. RADIOTHER ONCOL, 116(1), 119-24. https://doi.org/10.1016/j.radonc.2015.06.021

Vancouver

Karl A, Buchner A, Tympner C, Kirchner T, Ganswindt U, Belka C et al. Risk and timing of biochemical recurrence in pT3aN0/Nx prostate cancer with positive surgical margin - A multicenter study. RADIOTHER ONCOL. 2015 Jul;116(1):119-24. https://doi.org/10.1016/j.radonc.2015.06.021

Bibtex

@article{409be826ab9241d58fb1e08eb958f7dc,
title = "Risk and timing of biochemical recurrence in pT3aN0/Nx prostate cancer with positive surgical margin - A multicenter study",
abstract = "BACKGROUND AND PURPOSE: Positive surgical margins (PSM) after radical prostatectomy have been shown to be associated with impaired outcome. In pT3pN0 patients with PSM either immediate radiotherapy or clinical and biological monitoring followed by salvage radiotherapy is recommended by the latest guidelines of the European Association of Urology.MATERIALS AND METHODS: A retrospective, multicenter study of eight urological centers was conducted on 536 prostatectomy patients with pT3aN0/NxR1 tumors and no neoadjuvant/adjuvant therapy. A pathological re-review of all prostate specimens was performed. Association of clinical and pathological features with biochemical recurrence (BCR) was analyzed using univariate and multivariate analysis.RESULTS: With 48months median follow-up, BCR occurred in 39.7%. Preoperative PSA value, performance of pelvic lymph node dissection and Gleason score were significantly associated with BCR. In multivariate analysis, Gleason score was the only independent prognostic factor (p<0.001) for BCR. Five-year BCR-free survival rates were 74%, 70%, 38%, and 51% with Gleason score 6, 3+4=7a, 4+3=7b, and 8-10, respectively.CONCLUSIONS: In pT3aN0/NxR1 patients with no adjuvant/neoadjuvant treatment, Gleason Score permits independent prediction of the risk for BCR. These findings could help to estimate and discuss the individual risk for BCR with our patients on an individual basis.",
keywords = "Adult, Aged, Humans, Lymph Node Excision, Male, Middle Aged, Multivariate Analysis, Neoplasm Grading, Prostate-Specific Antigen, Prostatectomy, Prostatic Neoplasms, Recurrence, Retrospective Studies, Risk, Salvage Therapy, Survival Rate",
author = "Alexander Karl and Alexander Buchner and Christiane Tympner and Thomas Kirchner and Ute Ganswindt and Claus Belka and Roman Ganzer and Wolf Wieland and Fabian Eder and Ferdinand Hofst{\"a}dter and David Schilling and Karl-Dietrich Sievert and Arnulf Stenzl and Marcus Scharpf and Falko Fend and {Vom Dorp}, Frank and Herbert R{\"u}bben and {Kurt Werner}, Schmid and Daniel Porres-Knoblauch and Axel Heidenreich and Birgit Hangarter and Ruth Kn{\"u}chel-Clarke and Michael Rogenhofer and Bernd Wullich and Arndt Hartmann and Evi Comploj and Armin Pycha and Esther Hanspeter and Dirk Pehrke and Guido Sauter and Markus Graefen and Christian Gratzke and Christian Stief and Thomas Wiegel and Alexander Haese",
note = "Copyright {\textcopyright} 2015 Elsevier Ireland Ltd. All rights reserved.",
year = "2015",
month = jul,
doi = "10.1016/j.radonc.2015.06.021",
language = "English",
volume = "116",
pages = "119--24",
journal = "RADIOTHER ONCOL",
issn = "0167-8140",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Risk and timing of biochemical recurrence in pT3aN0/Nx prostate cancer with positive surgical margin - A multicenter study

AU - Karl, Alexander

AU - Buchner, Alexander

AU - Tympner, Christiane

AU - Kirchner, Thomas

AU - Ganswindt, Ute

AU - Belka, Claus

AU - Ganzer, Roman

AU - Wieland, Wolf

AU - Eder, Fabian

AU - Hofstädter, Ferdinand

AU - Schilling, David

AU - Sievert, Karl-Dietrich

AU - Stenzl, Arnulf

AU - Scharpf, Marcus

AU - Fend, Falko

AU - Vom Dorp, Frank

AU - Rübben, Herbert

AU - Kurt Werner, Schmid

AU - Porres-Knoblauch, Daniel

AU - Heidenreich, Axel

AU - Hangarter, Birgit

AU - Knüchel-Clarke, Ruth

AU - Rogenhofer, Michael

AU - Wullich, Bernd

AU - Hartmann, Arndt

AU - Comploj, Evi

AU - Pycha, Armin

AU - Hanspeter, Esther

AU - Pehrke, Dirk

AU - Sauter, Guido

AU - Graefen, Markus

AU - Gratzke, Christian

AU - Stief, Christian

AU - Wiegel, Thomas

AU - Haese, Alexander

N1 - Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

PY - 2015/7

Y1 - 2015/7

N2 - BACKGROUND AND PURPOSE: Positive surgical margins (PSM) after radical prostatectomy have been shown to be associated with impaired outcome. In pT3pN0 patients with PSM either immediate radiotherapy or clinical and biological monitoring followed by salvage radiotherapy is recommended by the latest guidelines of the European Association of Urology.MATERIALS AND METHODS: A retrospective, multicenter study of eight urological centers was conducted on 536 prostatectomy patients with pT3aN0/NxR1 tumors and no neoadjuvant/adjuvant therapy. A pathological re-review of all prostate specimens was performed. Association of clinical and pathological features with biochemical recurrence (BCR) was analyzed using univariate and multivariate analysis.RESULTS: With 48months median follow-up, BCR occurred in 39.7%. Preoperative PSA value, performance of pelvic lymph node dissection and Gleason score were significantly associated with BCR. In multivariate analysis, Gleason score was the only independent prognostic factor (p<0.001) for BCR. Five-year BCR-free survival rates were 74%, 70%, 38%, and 51% with Gleason score 6, 3+4=7a, 4+3=7b, and 8-10, respectively.CONCLUSIONS: In pT3aN0/NxR1 patients with no adjuvant/neoadjuvant treatment, Gleason Score permits independent prediction of the risk for BCR. These findings could help to estimate and discuss the individual risk for BCR with our patients on an individual basis.

AB - BACKGROUND AND PURPOSE: Positive surgical margins (PSM) after radical prostatectomy have been shown to be associated with impaired outcome. In pT3pN0 patients with PSM either immediate radiotherapy or clinical and biological monitoring followed by salvage radiotherapy is recommended by the latest guidelines of the European Association of Urology.MATERIALS AND METHODS: A retrospective, multicenter study of eight urological centers was conducted on 536 prostatectomy patients with pT3aN0/NxR1 tumors and no neoadjuvant/adjuvant therapy. A pathological re-review of all prostate specimens was performed. Association of clinical and pathological features with biochemical recurrence (BCR) was analyzed using univariate and multivariate analysis.RESULTS: With 48months median follow-up, BCR occurred in 39.7%. Preoperative PSA value, performance of pelvic lymph node dissection and Gleason score were significantly associated with BCR. In multivariate analysis, Gleason score was the only independent prognostic factor (p<0.001) for BCR. Five-year BCR-free survival rates were 74%, 70%, 38%, and 51% with Gleason score 6, 3+4=7a, 4+3=7b, and 8-10, respectively.CONCLUSIONS: In pT3aN0/NxR1 patients with no adjuvant/neoadjuvant treatment, Gleason Score permits independent prediction of the risk for BCR. These findings could help to estimate and discuss the individual risk for BCR with our patients on an individual basis.

KW - Adult

KW - Aged

KW - Humans

KW - Lymph Node Excision

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Neoplasm Grading

KW - Prostate-Specific Antigen

KW - Prostatectomy

KW - Prostatic Neoplasms

KW - Recurrence

KW - Retrospective Studies

KW - Risk

KW - Salvage Therapy

KW - Survival Rate

U2 - 10.1016/j.radonc.2015.06.021

DO - 10.1016/j.radonc.2015.06.021

M3 - SCORING: Journal article

C2 - 26138059

VL - 116

SP - 119

EP - 124

JO - RADIOTHER ONCOL

JF - RADIOTHER ONCOL

SN - 0167-8140

IS - 1

ER -