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Right ventricular dysfunction predicts poor outcome following hemodynamically compromising rejection

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Right ventricular dysfunction predicts poor outcome following hemodynamically compromising rejection. / Haddad, François; Fisher, Patrick; Pham, Michael; Berry, Gerald; Weisshaar, Dana; Kuppahally, Suman; Vrtovec, Bojan; Deuse, Tobias; Virani, Sean; Fearon, William; Valantine, Hannah; Hunt, Sharon.

in: J HEART LUNG TRANSPL, Jahrgang 28, Nr. 4, 04.2009, S. 312-319.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Haddad, F, Fisher, P, Pham, M, Berry, G, Weisshaar, D, Kuppahally, S, Vrtovec, B, Deuse, T, Virani, S, Fearon, W, Valantine, H & Hunt, S 2009, 'Right ventricular dysfunction predicts poor outcome following hemodynamically compromising rejection', J HEART LUNG TRANSPL, Jg. 28, Nr. 4, S. 312-319. https://doi.org/10.1016/j.healun.2008.12.023

APA

Haddad, F., Fisher, P., Pham, M., Berry, G., Weisshaar, D., Kuppahally, S., Vrtovec, B., Deuse, T., Virani, S., Fearon, W., Valantine, H., & Hunt, S. (2009). Right ventricular dysfunction predicts poor outcome following hemodynamically compromising rejection. J HEART LUNG TRANSPL, 28(4), 312-319. https://doi.org/10.1016/j.healun.2008.12.023

Vancouver

Haddad F, Fisher P, Pham M, Berry G, Weisshaar D, Kuppahally S et al. Right ventricular dysfunction predicts poor outcome following hemodynamically compromising rejection. J HEART LUNG TRANSPL. 2009 Apr;28(4):312-319. https://doi.org/10.1016/j.healun.2008.12.023

Bibtex

@article{b45de4d9a7634150a6e2cceead8633f8,
title = "Right ventricular dysfunction predicts poor outcome following hemodynamically compromising rejection",
abstract = "BACKGROUND: Hemodynamically compromising rejection (HCR) is a major cause of mortality and morbidity after heart transplantation. Right ventricular (RV) function is a strong predictor of outcome in patients with heart failure and myocarditis. The objective of the current study is to determine whether RV dysfunction predicts event-free survival in patients with HCR.METHODS: Medical records of 548 heart transplant patients followed at Stanford University between January 1998 and January 2007 were reviewed. HCR was defined as a rejection episode requiring hospitalization for heart failure. Univariate and multivariate analyses were performed to identify risk factors for death or retransplantation at 1 year.RESULTS: HCR occurred in 71 patients (12.9%). Death or retransplantation at 1 year occurred in 28 patients (39%). Univariate analysis identified non-cellular rejection (odds ratio [OR] = 3.20, p = 0.021), the need for inotropic support (OR = 4.80, p = 0.007), RV dysfunction (OR = 4.63, p = 0.006), left ventricular ejection fraction (OR = 0.941, p = 0.031) and acute renal failure (OR = 3.82, p = 0.010) as predictors of death or retransplantation at 1 year. Multivariate analysis identified RV dysfunction (OR = 4.80, p = 0.007) and the need for inotropic support (OR = 5.00, p = 0.009) as predictors of death or retransplantation at 1 year.CONCLUSIONS: In the modern era of immunosuppression, HCR remains a major complication after heart transplantation. RV dysfunction was identified as a novel risk factor for death or retransplantation following HCR.",
keywords = "Acute Kidney Injury/epidemiology, Adult, Creatinine/blood, Female, Follow-Up Studies, Graft Rejection/epidemiology, Heart Failure/surgery, Heart Transplantation/adverse effects, Humans, Male, Middle Aged, Myocarditis/surgery, Retrospective Studies, Risk Factors, Survival Rate, Survivors, Time Factors, Treatment Failure, Treatment Outcome, Ventricular Dysfunction, Right/epidemiology",
author = "Fran{\c c}ois Haddad and Patrick Fisher and Michael Pham and Gerald Berry and Dana Weisshaar and Suman Kuppahally and Bojan Vrtovec and Tobias Deuse and Sean Virani and William Fearon and Hannah Valantine and Sharon Hunt",
year = "2009",
month = apr,
doi = "10.1016/j.healun.2008.12.023",
language = "English",
volume = "28",
pages = "312--319",
journal = "J HEART LUNG TRANSPL",
issn = "1053-2498",
publisher = "Elsevier USA",
number = "4",

}

RIS

TY - JOUR

T1 - Right ventricular dysfunction predicts poor outcome following hemodynamically compromising rejection

AU - Haddad, François

AU - Fisher, Patrick

AU - Pham, Michael

AU - Berry, Gerald

AU - Weisshaar, Dana

AU - Kuppahally, Suman

AU - Vrtovec, Bojan

AU - Deuse, Tobias

AU - Virani, Sean

AU - Fearon, William

AU - Valantine, Hannah

AU - Hunt, Sharon

PY - 2009/4

Y1 - 2009/4

N2 - BACKGROUND: Hemodynamically compromising rejection (HCR) is a major cause of mortality and morbidity after heart transplantation. Right ventricular (RV) function is a strong predictor of outcome in patients with heart failure and myocarditis. The objective of the current study is to determine whether RV dysfunction predicts event-free survival in patients with HCR.METHODS: Medical records of 548 heart transplant patients followed at Stanford University between January 1998 and January 2007 were reviewed. HCR was defined as a rejection episode requiring hospitalization for heart failure. Univariate and multivariate analyses were performed to identify risk factors for death or retransplantation at 1 year.RESULTS: HCR occurred in 71 patients (12.9%). Death or retransplantation at 1 year occurred in 28 patients (39%). Univariate analysis identified non-cellular rejection (odds ratio [OR] = 3.20, p = 0.021), the need for inotropic support (OR = 4.80, p = 0.007), RV dysfunction (OR = 4.63, p = 0.006), left ventricular ejection fraction (OR = 0.941, p = 0.031) and acute renal failure (OR = 3.82, p = 0.010) as predictors of death or retransplantation at 1 year. Multivariate analysis identified RV dysfunction (OR = 4.80, p = 0.007) and the need for inotropic support (OR = 5.00, p = 0.009) as predictors of death or retransplantation at 1 year.CONCLUSIONS: In the modern era of immunosuppression, HCR remains a major complication after heart transplantation. RV dysfunction was identified as a novel risk factor for death or retransplantation following HCR.

AB - BACKGROUND: Hemodynamically compromising rejection (HCR) is a major cause of mortality and morbidity after heart transplantation. Right ventricular (RV) function is a strong predictor of outcome in patients with heart failure and myocarditis. The objective of the current study is to determine whether RV dysfunction predicts event-free survival in patients with HCR.METHODS: Medical records of 548 heart transplant patients followed at Stanford University between January 1998 and January 2007 were reviewed. HCR was defined as a rejection episode requiring hospitalization for heart failure. Univariate and multivariate analyses were performed to identify risk factors for death or retransplantation at 1 year.RESULTS: HCR occurred in 71 patients (12.9%). Death or retransplantation at 1 year occurred in 28 patients (39%). Univariate analysis identified non-cellular rejection (odds ratio [OR] = 3.20, p = 0.021), the need for inotropic support (OR = 4.80, p = 0.007), RV dysfunction (OR = 4.63, p = 0.006), left ventricular ejection fraction (OR = 0.941, p = 0.031) and acute renal failure (OR = 3.82, p = 0.010) as predictors of death or retransplantation at 1 year. Multivariate analysis identified RV dysfunction (OR = 4.80, p = 0.007) and the need for inotropic support (OR = 5.00, p = 0.009) as predictors of death or retransplantation at 1 year.CONCLUSIONS: In the modern era of immunosuppression, HCR remains a major complication after heart transplantation. RV dysfunction was identified as a novel risk factor for death or retransplantation following HCR.

KW - Acute Kidney Injury/epidemiology

KW - Adult

KW - Creatinine/blood

KW - Female

KW - Follow-Up Studies

KW - Graft Rejection/epidemiology

KW - Heart Failure/surgery

KW - Heart Transplantation/adverse effects

KW - Humans

KW - Male

KW - Middle Aged

KW - Myocarditis/surgery

KW - Retrospective Studies

KW - Risk Factors

KW - Survival Rate

KW - Survivors

KW - Time Factors

KW - Treatment Failure

KW - Treatment Outcome

KW - Ventricular Dysfunction, Right/epidemiology

U2 - 10.1016/j.healun.2008.12.023

DO - 10.1016/j.healun.2008.12.023

M3 - SCORING: Journal article

C2 - 19332256

VL - 28

SP - 312

EP - 319

JO - J HEART LUNG TRANSPL

JF - J HEART LUNG TRANSPL

SN - 1053-2498

IS - 4

ER -