Reward anticipation in the adolescent and aging brain
Standard
Reward anticipation in the adolescent and aging brain. / Lorenz, Robert C; Gleich, Tobias; Beck, Anne; Pöhland, Lydia; Raufelder, Diana; Sommer, Werner; Rapp, Michael A; Kühn, Simone; Gallinat, Jürgen.
in: HUM BRAIN MAPP, Jahrgang 35, Nr. 10, 10.2014, S. 5153-65.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Reward anticipation in the adolescent and aging brain
AU - Lorenz, Robert C
AU - Gleich, Tobias
AU - Beck, Anne
AU - Pöhland, Lydia
AU - Raufelder, Diana
AU - Sommer, Werner
AU - Rapp, Michael A
AU - Kühn, Simone
AU - Gallinat, Jürgen
N1 - Copyright © 2014 Wiley Periodicals, Inc.
PY - 2014/10
Y1 - 2014/10
N2 - Processing of reward is the basis of adaptive behavior of the human being. Neural correlates of reward processing seem to be influenced by developmental changes from adolescence to late adulthood. The aim of this study is to uncover these neural correlates during a slot machine gambling task across the lifespan. Therefore, we used functional magnetic resonance imaging to investigate 102 volunteers in three different age groups: 34 adolescents, 34 younger adults, and 34 older adults. We focused on the core reward areas ventral striatum (VS) and ventromedial prefrontal cortex (VMPFC), the valence processing associated areas, anterior cingulate cortex (ACC) and insula, as well as information integration associated areas, dorsolateral prefrontal cortex (DLPFC), and inferior parietal lobule (IPL). Results showed that VS and VMPFC were characterized by a hyperactivation in adolescents compared with younger adults. Furthermore, the ACC and insula were characterized by a U-shape pattern (hypoactivation in younger adults compared with adolescents and older adults), whereas the DLPFC and IPL were characterized by a J-shaped form (hyperactivation in older adults compared with younger groups). Furthermore, a functional connectivity analysis revealed an elevated negative functional coupling between the inhibition-related area rIFG and VS in younger adults compared with adolescents. Results indicate that lifespan-related changes during reward anticipation are characterized by different trajectories in different reward network modules and support the hypothesis of an imbalance in maturation of striatal and prefrontal cortex in adolescents. Furthermore, these results suggest compensatory age-specific effects in fronto-parietal regions.
AB - Processing of reward is the basis of adaptive behavior of the human being. Neural correlates of reward processing seem to be influenced by developmental changes from adolescence to late adulthood. The aim of this study is to uncover these neural correlates during a slot machine gambling task across the lifespan. Therefore, we used functional magnetic resonance imaging to investigate 102 volunteers in three different age groups: 34 adolescents, 34 younger adults, and 34 older adults. We focused on the core reward areas ventral striatum (VS) and ventromedial prefrontal cortex (VMPFC), the valence processing associated areas, anterior cingulate cortex (ACC) and insula, as well as information integration associated areas, dorsolateral prefrontal cortex (DLPFC), and inferior parietal lobule (IPL). Results showed that VS and VMPFC were characterized by a hyperactivation in adolescents compared with younger adults. Furthermore, the ACC and insula were characterized by a U-shape pattern (hypoactivation in younger adults compared with adolescents and older adults), whereas the DLPFC and IPL were characterized by a J-shaped form (hyperactivation in older adults compared with younger groups). Furthermore, a functional connectivity analysis revealed an elevated negative functional coupling between the inhibition-related area rIFG and VS in younger adults compared with adolescents. Results indicate that lifespan-related changes during reward anticipation are characterized by different trajectories in different reward network modules and support the hypothesis of an imbalance in maturation of striatal and prefrontal cortex in adolescents. Furthermore, these results suggest compensatory age-specific effects in fronto-parietal regions.
KW - Adolescent
KW - Adult
KW - Age Factors
KW - Aged
KW - Aged, 80 and over
KW - Aging
KW - Brain
KW - Brain Mapping
KW - Female
KW - Games, Experimental
KW - Humans
KW - Image Processing, Computer-Assisted
KW - Linear Models
KW - Magnetic Resonance Imaging
KW - Male
KW - Middle Aged
KW - Motivation
KW - Oxygen
KW - Reward
KW - Young Adult
U2 - 10.1002/hbm.22540
DO - 10.1002/hbm.22540
M3 - SCORING: Journal article
C2 - 24801222
VL - 35
SP - 5153
EP - 5165
JO - HUM BRAIN MAPP
JF - HUM BRAIN MAPP
SN - 1065-9471
IS - 10
ER -
