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Revisiting potential associations between brain morphology, fear acquisition and extinction through new data and a literature review

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Revisiting potential associations between brain morphology, fear acquisition and extinction through new data and a literature review. / Ehlers, Mana R; Nold, Janne; Kuhn, Manuel; Klingelhöfer-Jens, Maren; Lonsdorf, Tina B.

in: SCI REP-UK, Jahrgang 10, Nr. 1, 16.11.2020, S. 19894.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Ehlers, MR, Nold, J, Kuhn, M, Klingelhöfer-Jens, M & Lonsdorf, TB 2020, 'Revisiting potential associations between brain morphology, fear acquisition and extinction through new data and a literature review', SCI REP-UK, Jg. 10, Nr. 1, S. 19894. https://doi.org/10.1038/s41598-020-76683-1

APA

Ehlers, M. R., Nold, J., Kuhn, M., Klingelhöfer-Jens, M., & Lonsdorf, T. B. (2020). Revisiting potential associations between brain morphology, fear acquisition and extinction through new data and a literature review. SCI REP-UK, 10(1), 19894. https://doi.org/10.1038/s41598-020-76683-1

Vancouver

Ehlers MR, Nold J, Kuhn M, Klingelhöfer-Jens M, Lonsdorf TB. Revisiting potential associations between brain morphology, fear acquisition and extinction through new data and a literature review. SCI REP-UK. 2020 Nov 16;10(1):19894. https://doi.org/10.1038/s41598-020-76683-1

Bibtex

@article{4546b1a1b6ac4a0c9ae7ce1ae8e493fd,
title = "Revisiting potential associations between brain morphology, fear acquisition and extinction through new data and a literature review",
abstract = "Inter-individual differences in defensive responding are widely established but their morphological correlates in humans have not been investigated exhaustively. Previous studies reported associations with cortical thickness of the dorsal anterior cingulate cortex, insula and medial orbitofrontal cortex as well as amygdala volume in fear conditioning studies. However, these associations are partly inconsistent and often derived from small samples. The current study aimed to replicate previously reported associations between physiological and subjective measures of fear acquisition and extinction and brain morphology. Structural magnetic resonance imaging was performed on 107 healthy adults who completed a differential cued fear conditioning paradigm with 24 h delayed extinction while skin conductance response (SCR) and fear ratings were recorded. Cortical thickness and subcortical volume were obtained using the software Freesurfer. Results obtained by traditional null hypothesis significance testing and Bayesians statistics do not support structural brain-behavior relationships: Neither differential SCR nor fear ratings during fear acquisition or extinction training could be predicted by cortical thickness or subcortical volume in regions previously reported. In summary, the current pre-registered study does not corroborate associations between brain morphology and inter-individual differences in defensive responding but differences in experimental design and analyses approaches compared to previous work should be acknowledged.",
keywords = "Adolescent, Adult, Amygdala/physiopathology, Anxiety/physiopathology, Brain Mapping, Brain/anatomy & histology, Cerebral Cortex/physiopathology, Extinction, Psychological, Fear/physiology, Female, Healthy Volunteers, Humans, Individuality, Longitudinal Studies, Male, Mental Recall, Young Adult",
author = "Ehlers, {Mana R} and Janne Nold and Manuel Kuhn and Maren Klingelh{\"o}fer-Jens and Lonsdorf, {Tina B}",
year = "2020",
month = nov,
day = "16",
doi = "10.1038/s41598-020-76683-1",
language = "English",
volume = "10",
pages = "19894",
journal = "SCI REP-UK",
issn = "2045-2322",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Revisiting potential associations between brain morphology, fear acquisition and extinction through new data and a literature review

AU - Ehlers, Mana R

AU - Nold, Janne

AU - Kuhn, Manuel

AU - Klingelhöfer-Jens, Maren

AU - Lonsdorf, Tina B

PY - 2020/11/16

Y1 - 2020/11/16

N2 - Inter-individual differences in defensive responding are widely established but their morphological correlates in humans have not been investigated exhaustively. Previous studies reported associations with cortical thickness of the dorsal anterior cingulate cortex, insula and medial orbitofrontal cortex as well as amygdala volume in fear conditioning studies. However, these associations are partly inconsistent and often derived from small samples. The current study aimed to replicate previously reported associations between physiological and subjective measures of fear acquisition and extinction and brain morphology. Structural magnetic resonance imaging was performed on 107 healthy adults who completed a differential cued fear conditioning paradigm with 24 h delayed extinction while skin conductance response (SCR) and fear ratings were recorded. Cortical thickness and subcortical volume were obtained using the software Freesurfer. Results obtained by traditional null hypothesis significance testing and Bayesians statistics do not support structural brain-behavior relationships: Neither differential SCR nor fear ratings during fear acquisition or extinction training could be predicted by cortical thickness or subcortical volume in regions previously reported. In summary, the current pre-registered study does not corroborate associations between brain morphology and inter-individual differences in defensive responding but differences in experimental design and analyses approaches compared to previous work should be acknowledged.

AB - Inter-individual differences in defensive responding are widely established but their morphological correlates in humans have not been investigated exhaustively. Previous studies reported associations with cortical thickness of the dorsal anterior cingulate cortex, insula and medial orbitofrontal cortex as well as amygdala volume in fear conditioning studies. However, these associations are partly inconsistent and often derived from small samples. The current study aimed to replicate previously reported associations between physiological and subjective measures of fear acquisition and extinction and brain morphology. Structural magnetic resonance imaging was performed on 107 healthy adults who completed a differential cued fear conditioning paradigm with 24 h delayed extinction while skin conductance response (SCR) and fear ratings were recorded. Cortical thickness and subcortical volume were obtained using the software Freesurfer. Results obtained by traditional null hypothesis significance testing and Bayesians statistics do not support structural brain-behavior relationships: Neither differential SCR nor fear ratings during fear acquisition or extinction training could be predicted by cortical thickness or subcortical volume in regions previously reported. In summary, the current pre-registered study does not corroborate associations between brain morphology and inter-individual differences in defensive responding but differences in experimental design and analyses approaches compared to previous work should be acknowledged.

KW - Adolescent

KW - Adult

KW - Amygdala/physiopathology

KW - Anxiety/physiopathology

KW - Brain Mapping

KW - Brain/anatomy & histology

KW - Cerebral Cortex/physiopathology

KW - Extinction, Psychological

KW - Fear/physiology

KW - Female

KW - Healthy Volunteers

KW - Humans

KW - Individuality

KW - Longitudinal Studies

KW - Male

KW - Mental Recall

KW - Young Adult

U2 - 10.1038/s41598-020-76683-1

DO - 10.1038/s41598-020-76683-1

M3 - SCORING: Journal article

C2 - 33199738

VL - 10

SP - 19894

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

IS - 1

ER -