Retroperitoneal sarcoma in a series of 51 adults.

TY - JOUR

T1 - Retroperitoneal sarcoma in a series of 51 adults.

AU - Zornig, C

AU - Weh, H J

AU - Krüll, Andreas

AU - Schwarz, R

AU - Dieckmann, J

AU - Rehpenning, W

AU - Schröder, S

PY - 1992

Y1 - 1992

N2 - Fifty-one patients with retroperitoneal sarcoma underwent surgery at the University Clinics of Hamburg from 1970 to 1988. Malignant schwannoma, liposarcoma and malignant fibrous histiocytoma were the most common histological types. High grade sarcomas (G3) predominated (42%), while 26% were graded G2 and 33% G1. Complete resection was possible in 59% of cases. Reoperation for local recurrence and debulking in case of not completely resectable disease was common. Regional lymph node metastasis was found in 20% of cases. The peritoneum was the preferred location of metastatic spread. All adjuvant chemotherapies were followed by tumour recurrences. After adjuvant radiotherapy three of six patients remained free of disease. In cases of residual tumour we observed few partial responses on chemo- and radiotherapy, and all patients died because of the disease. The mean survival time was 60 months, the 5- and 10-year survival rates were 35% and 15%, respectively. Factors influencing prognosis in univariate analysis included grade, size, resectability, presence of metastatic spread, histological type, microscopic local growth (infiltrative vs intact pseudocapsule of fibrous tissue) and local recurrence. With multivariate analysis grade, size and lymph node metastasis retained their prognostic significance.

AB - Fifty-one patients with retroperitoneal sarcoma underwent surgery at the University Clinics of Hamburg from 1970 to 1988. Malignant schwannoma, liposarcoma and malignant fibrous histiocytoma were the most common histological types. High grade sarcomas (G3) predominated (42%), while 26% were graded G2 and 33% G1. Complete resection was possible in 59% of cases. Reoperation for local recurrence and debulking in case of not completely resectable disease was common. Regional lymph node metastasis was found in 20% of cases. The peritoneum was the preferred location of metastatic spread. All adjuvant chemotherapies were followed by tumour recurrences. After adjuvant radiotherapy three of six patients remained free of disease. In cases of residual tumour we observed few partial responses on chemo- and radiotherapy, and all patients died because of the disease. The mean survival time was 60 months, the 5- and 10-year survival rates were 35% and 15%, respectively. Factors influencing prognosis in univariate analysis included grade, size, resectability, presence of metastatic spread, histological type, microscopic local growth (infiltrative vs intact pseudocapsule of fibrous tissue) and local recurrence. With multivariate analysis grade, size and lymph node metastasis retained their prognostic significance.

KW - Adult

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Middle Aged

KW - Adolescent

KW - Multivariate Analysis

KW - Regression Analysis

KW - Lymphatic Metastasis

KW - Prognosis

KW - Survival Rate

KW - Follow-Up Studies

KW - Combined Modality Therapy

KW - Neoplasm Metastasis

KW - Neoplasm Invasiveness

KW - Retroperitoneal Neoplasms/mortality/pathology/surgery

KW - Sarcoma/mortality/pathology/surgery

KW - Adult

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Middle Aged

KW - Adolescent

KW - Multivariate Analysis

KW - Regression Analysis

KW - Lymphatic Metastasis

KW - Prognosis

KW - Survival Rate

KW - Follow-Up Studies

KW - Combined Modality Therapy

KW - Neoplasm Metastasis

KW - Neoplasm Invasiveness

KW - Retroperitoneal Neoplasms/mortality/pathology/surgery

KW - Sarcoma/mortality/pathology/surgery

M3 - SCORING: Journal article

VL - 18

SP - 475

EP - 480

JO - EJSO-EUR J SURG ONC

JF - EJSO-EUR J SURG ONC

SN - 0748-7983

IS - 5

M1 - 5

ER -