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Retinoic acid drives intestine-specific adaptation of effector ILC2s originating from distant sites

Standard

Retinoic acid drives intestine-specific adaptation of effector ILC2s originating from distant sites. / Shaikh, Nikhat; Waterhölter, Alex; Gnirck, Ann-Christin; Becker, Martina; Adamiak, Virginia; Henneken, Lena; Wunderlich, Malte; Hartmann, Wiebke; Linnemann, Lara; Huber, Tobias B; Krebs, Christian F; Panzer, Ulf; Locksley, Richard M; Wilhelm, Christoph; Breloer, Minka; Turner, Jan-Eric.

in: J EXP MED, Jahrgang 220, Nr. 12, e20221015, 04.12.2023.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Shaikh, N, Waterhölter, A, Gnirck, A-C, Becker, M, Adamiak, V, Henneken, L, Wunderlich, M, Hartmann, W, Linnemann, L, Huber, TB, Krebs, CF, Panzer, U, Locksley, RM, Wilhelm, C, Breloer, M & Turner, J-E 2023, 'Retinoic acid drives intestine-specific adaptation of effector ILC2s originating from distant sites', J EXP MED, Jg. 220, Nr. 12, e20221015. https://doi.org/10.1084/jem.20221015

APA

Shaikh, N., Waterhölter, A., Gnirck, A-C., Becker, M., Adamiak, V., Henneken, L., Wunderlich, M., Hartmann, W., Linnemann, L., Huber, T. B., Krebs, C. F., Panzer, U., Locksley, R. M., Wilhelm, C., Breloer, M., & Turner, J-E. (2023). Retinoic acid drives intestine-specific adaptation of effector ILC2s originating from distant sites. J EXP MED, 220(12), [e20221015]. https://doi.org/10.1084/jem.20221015

Vancouver

Shaikh N, Waterhölter A, Gnirck A-C, Becker M, Adamiak V, Henneken L et al. Retinoic acid drives intestine-specific adaptation of effector ILC2s originating from distant sites. J EXP MED. 2023 Dez 4;220(12). e20221015. https://doi.org/10.1084/jem.20221015

Bibtex

@article{5bc6634176e14068a8779b5537d37bcf,
title = "Retinoic acid drives intestine-specific adaptation of effector ILC2s originating from distant sites",
abstract = "Adaptation of immune cells to tissue-specific microenvironments is a crucial process in homeostasis and inflammation. Here, we show that murine effector type 2 innate lymphoid cells (ILC2s) from various organs are equally effective in repopulating ILC2 niches in other anatomical locations where they adapt tissue-specific phenotypes of target organs. Single-cell transcriptomics of ILC2 populations revealed upregulation of retinoic acid (RA) signaling in ILC2s during adaptation to the small intestinal microenvironment, and RA signaling mediated reprogramming of kidney effector ILC2s toward the small intestinal phenotype in vitro and in vivo. Inhibition of intestinal ILC2 adaptation by blocking RA signaling impaired worm expulsion during Strongyloides ratti infection, indicating functional importance of ILC2 tissue imprinting. In conclusion, this study highlights that effector ILC2s retain the ability to adapt to changing tissue-specific microenvironments, enabling them to exert tissue-specific functions, such as promoting control of intestinal helminth infections.",
keywords = "Mice, Animals, Immunity, Innate, Tretinoin/pharmacology, Lymphocytes, Intestines, Inflammation, Cytokines",
author = "Nikhat Shaikh and Alex Waterh{\"o}lter and Ann-Christin Gnirck and Martina Becker and Virginia Adamiak and Lena Henneken and Malte Wunderlich and Wiebke Hartmann and Lara Linnemann and Huber, {Tobias B} and Krebs, {Christian F} and Ulf Panzer and Locksley, {Richard M} and Christoph Wilhelm and Minka Breloer and Jan-Eric Turner",
note = "{\textcopyright} 2023 Shaikh et al.",
year = "2023",
month = dec,
day = "4",
doi = "10.1084/jem.20221015",
language = "English",
volume = "220",
journal = "J EXP MED",
issn = "0022-1007",
publisher = "Rockefeller University Press",
number = "12",

}

RIS

TY - JOUR

T1 - Retinoic acid drives intestine-specific adaptation of effector ILC2s originating from distant sites

AU - Shaikh, Nikhat

AU - Waterhölter, Alex

AU - Gnirck, Ann-Christin

AU - Becker, Martina

AU - Adamiak, Virginia

AU - Henneken, Lena

AU - Wunderlich, Malte

AU - Hartmann, Wiebke

AU - Linnemann, Lara

AU - Huber, Tobias B

AU - Krebs, Christian F

AU - Panzer, Ulf

AU - Locksley, Richard M

AU - Wilhelm, Christoph

AU - Breloer, Minka

AU - Turner, Jan-Eric

N1 - © 2023 Shaikh et al.

PY - 2023/12/4

Y1 - 2023/12/4

N2 - Adaptation of immune cells to tissue-specific microenvironments is a crucial process in homeostasis and inflammation. Here, we show that murine effector type 2 innate lymphoid cells (ILC2s) from various organs are equally effective in repopulating ILC2 niches in other anatomical locations where they adapt tissue-specific phenotypes of target organs. Single-cell transcriptomics of ILC2 populations revealed upregulation of retinoic acid (RA) signaling in ILC2s during adaptation to the small intestinal microenvironment, and RA signaling mediated reprogramming of kidney effector ILC2s toward the small intestinal phenotype in vitro and in vivo. Inhibition of intestinal ILC2 adaptation by blocking RA signaling impaired worm expulsion during Strongyloides ratti infection, indicating functional importance of ILC2 tissue imprinting. In conclusion, this study highlights that effector ILC2s retain the ability to adapt to changing tissue-specific microenvironments, enabling them to exert tissue-specific functions, such as promoting control of intestinal helminth infections.

AB - Adaptation of immune cells to tissue-specific microenvironments is a crucial process in homeostasis and inflammation. Here, we show that murine effector type 2 innate lymphoid cells (ILC2s) from various organs are equally effective in repopulating ILC2 niches in other anatomical locations where they adapt tissue-specific phenotypes of target organs. Single-cell transcriptomics of ILC2 populations revealed upregulation of retinoic acid (RA) signaling in ILC2s during adaptation to the small intestinal microenvironment, and RA signaling mediated reprogramming of kidney effector ILC2s toward the small intestinal phenotype in vitro and in vivo. Inhibition of intestinal ILC2 adaptation by blocking RA signaling impaired worm expulsion during Strongyloides ratti infection, indicating functional importance of ILC2 tissue imprinting. In conclusion, this study highlights that effector ILC2s retain the ability to adapt to changing tissue-specific microenvironments, enabling them to exert tissue-specific functions, such as promoting control of intestinal helminth infections.

KW - Mice

KW - Animals

KW - Immunity, Innate

KW - Tretinoin/pharmacology

KW - Lymphocytes

KW - Intestines

KW - Inflammation

KW - Cytokines

U2 - 10.1084/jem.20221015

DO - 10.1084/jem.20221015

M3 - SCORING: Journal article

C2 - 37773047

VL - 220

JO - J EXP MED

JF - J EXP MED

SN - 0022-1007

IS - 12

M1 - e20221015

ER -