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Ret and Substrate-Derived TGF-β Maverick Regulate Space-Filling Dendrite Growth in Drosophila Sensory Neurons

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Ret and Substrate-Derived TGF-β Maverick Regulate Space-Filling Dendrite Growth in Drosophila Sensory Neurons. / Hoyer, Nina; Zielke, Philip; Hu, Chun; Petersen, Meike; Sauter, Kathrin; Scharrenberg, Robin; Peng, Yun; Kim, Charles C; Han, Chun; Parrish, Jay Z; Soba, Peter.

in: CELL REP, Jahrgang 24, Nr. 9, 28.08.2018, S. 2261-2272.e5.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Hoyer, N, Zielke, P, Hu, C, Petersen, M, Sauter, K, Scharrenberg, R, Peng, Y, Kim, CC, Han, C, Parrish, JZ & Soba, P 2018, 'Ret and Substrate-Derived TGF-β Maverick Regulate Space-Filling Dendrite Growth in Drosophila Sensory Neurons', CELL REP, Jg. 24, Nr. 9, S. 2261-2272.e5. https://doi.org/10.1016/j.celrep.2018.07.092

APA

Hoyer, N., Zielke, P., Hu, C., Petersen, M., Sauter, K., Scharrenberg, R., Peng, Y., Kim, C. C., Han, C., Parrish, J. Z., & Soba, P. (2018). Ret and Substrate-Derived TGF-β Maverick Regulate Space-Filling Dendrite Growth in Drosophila Sensory Neurons. CELL REP, 24(9), 2261-2272.e5. https://doi.org/10.1016/j.celrep.2018.07.092

Vancouver

Hoyer N, Zielke P, Hu C, Petersen M, Sauter K, Scharrenberg R et al. Ret and Substrate-Derived TGF-β Maverick Regulate Space-Filling Dendrite Growth in Drosophila Sensory Neurons. CELL REP. 2018 Aug 28;24(9):2261-2272.e5. https://doi.org/10.1016/j.celrep.2018.07.092

Bibtex

@article{a7c850a491f54538933d681da3de3e85,
title = "Ret and Substrate-Derived TGF-β Maverick Regulate Space-Filling Dendrite Growth in Drosophila Sensory Neurons",
abstract = "Dendrite morphogenesis is a highly regulated process that gives rise to stereotyped receptive fields, which are required for proper neuronal connectivity and function. Specific classes of neurons, including Drosophila class IV dendritic arborization (C4da) neurons, also feature complete space-filling growth of dendrites. In this system, we have identified the substrate-derived TGF-β ligand maverick (mav) as a developmental signal promoting space-filling growth through the neuronal Ret receptor. Both are necessary for radial spreading of C4da neuron dendrites, and Ret is required for neuronal uptake of Mav. Moreover, local changes in Mav levels result in directed dendritic growth toward regions with higher ligand availability. Our results suggest that Mav acts as a substrate-derived secreted signal promoting dendrite growth within not-yet-covered areas of the receptive field to ensure space-filling dendritic growth.",
keywords = "Journal Article",
author = "Nina Hoyer and Philip Zielke and Chun Hu and Meike Petersen and Kathrin Sauter and Robin Scharrenberg and Yun Peng and Kim, {Charles C} and Chun Han and Parrish, {Jay Z} and Peter Soba",
note = "Copyright {\textcopyright} 2018 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2018",
month = aug,
day = "28",
doi = "10.1016/j.celrep.2018.07.092",
language = "English",
volume = "24",
pages = "2261--2272.e5",
journal = "CELL REP",
issn = "2211-1247",
publisher = "Elsevier",
number = "9",

}

RIS

TY - JOUR

T1 - Ret and Substrate-Derived TGF-β Maverick Regulate Space-Filling Dendrite Growth in Drosophila Sensory Neurons

AU - Hoyer, Nina

AU - Zielke, Philip

AU - Hu, Chun

AU - Petersen, Meike

AU - Sauter, Kathrin

AU - Scharrenberg, Robin

AU - Peng, Yun

AU - Kim, Charles C

AU - Han, Chun

AU - Parrish, Jay Z

AU - Soba, Peter

N1 - Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2018/8/28

Y1 - 2018/8/28

N2 - Dendrite morphogenesis is a highly regulated process that gives rise to stereotyped receptive fields, which are required for proper neuronal connectivity and function. Specific classes of neurons, including Drosophila class IV dendritic arborization (C4da) neurons, also feature complete space-filling growth of dendrites. In this system, we have identified the substrate-derived TGF-β ligand maverick (mav) as a developmental signal promoting space-filling growth through the neuronal Ret receptor. Both are necessary for radial spreading of C4da neuron dendrites, and Ret is required for neuronal uptake of Mav. Moreover, local changes in Mav levels result in directed dendritic growth toward regions with higher ligand availability. Our results suggest that Mav acts as a substrate-derived secreted signal promoting dendrite growth within not-yet-covered areas of the receptive field to ensure space-filling dendritic growth.

AB - Dendrite morphogenesis is a highly regulated process that gives rise to stereotyped receptive fields, which are required for proper neuronal connectivity and function. Specific classes of neurons, including Drosophila class IV dendritic arborization (C4da) neurons, also feature complete space-filling growth of dendrites. In this system, we have identified the substrate-derived TGF-β ligand maverick (mav) as a developmental signal promoting space-filling growth through the neuronal Ret receptor. Both are necessary for radial spreading of C4da neuron dendrites, and Ret is required for neuronal uptake of Mav. Moreover, local changes in Mav levels result in directed dendritic growth toward regions with higher ligand availability. Our results suggest that Mav acts as a substrate-derived secreted signal promoting dendrite growth within not-yet-covered areas of the receptive field to ensure space-filling dendritic growth.

KW - Journal Article

U2 - 10.1016/j.celrep.2018.07.092

DO - 10.1016/j.celrep.2018.07.092

M3 - SCORING: Journal article

C2 - 30157422

VL - 24

SP - 2261-2272.e5

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 9

ER -