Results of modern mitral valve repair in patients with Marfan syndrome
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Results of modern mitral valve repair in patients with Marfan syndrome. / Bernhardt, Alexander Martin; Treede, Hendrik; Detter, Christian; Rybczynski, Meike; Sheikhzadeh, Sara; Wagner, Florian Mathias; Von Kodolitsch, Yskert; Reichenspurner, Hermann.
in: THORAC CARDIOV SURG, Jahrgang 62, Nr. 1, 02.2014, S. 35-41.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Results of modern mitral valve repair in patients with Marfan syndrome
AU - Bernhardt, Alexander Martin
AU - Treede, Hendrik
AU - Detter, Christian
AU - Rybczynski, Meike
AU - Sheikhzadeh, Sara
AU - Wagner, Florian Mathias
AU - Von Kodolitsch, Yskert
AU - Reichenspurner, Hermann
N1 - Georg Thieme Verlag KG Stuttgart · New York.
PY - 2014/2
Y1 - 2014/2
N2 - OBJECTIVES: Mitral valve (MV) regurgitation is a common manifestation in patients with Marfan syndrome (MFS) and is age dependent. Valve pathology shares some features with myxomatous MV disease. Surgical treatment is still being debated and not well characterized in patients with MFS.PATIENTS AND METHODS: We retrospectively evaluated the results of mitral valve repair (MVR) of symptomatic patients with MFS who underwent surgery between January 2004 and April 2011. MFS was diagnosed following the Ghent criteria. MVR was performed in 12 patients. Three patients underwent minimally invasive MVR despite severe thorax deformities. Mean follow-up was 60.1 months (95% CI: 48-72) and was complete.RESULTS: Thirty-day mortality was 0%. One patient died because of arrhythmia 66 months after MVR. Transthoracic echocardiography at last visit showed mild mitral regurgitation in one patient (8.3%) and no mitral regurgitation in the remaining patients (91.7%).CONCLUSION: MVR was associated with excellent survival and a low rate of complications. Transthoracic echocardiography showed good results of the repaired valves even years later. Minimally invasive repairs are feasible even in deformed thoraces, lowering the risk for future aortic surgery. Because of excellent mid-term to long-term results, MVR may also be justified in asymptomatic Marfan patients.
AB - OBJECTIVES: Mitral valve (MV) regurgitation is a common manifestation in patients with Marfan syndrome (MFS) and is age dependent. Valve pathology shares some features with myxomatous MV disease. Surgical treatment is still being debated and not well characterized in patients with MFS.PATIENTS AND METHODS: We retrospectively evaluated the results of mitral valve repair (MVR) of symptomatic patients with MFS who underwent surgery between January 2004 and April 2011. MFS was diagnosed following the Ghent criteria. MVR was performed in 12 patients. Three patients underwent minimally invasive MVR despite severe thorax deformities. Mean follow-up was 60.1 months (95% CI: 48-72) and was complete.RESULTS: Thirty-day mortality was 0%. One patient died because of arrhythmia 66 months after MVR. Transthoracic echocardiography at last visit showed mild mitral regurgitation in one patient (8.3%) and no mitral regurgitation in the remaining patients (91.7%).CONCLUSION: MVR was associated with excellent survival and a low rate of complications. Transthoracic echocardiography showed good results of the repaired valves even years later. Minimally invasive repairs are feasible even in deformed thoraces, lowering the risk for future aortic surgery. Because of excellent mid-term to long-term results, MVR may also be justified in asymptomatic Marfan patients.
KW - Adolescent
KW - Adult
KW - Aged
KW - Female
KW - Heart Valve Prosthesis Implantation/adverse effects
KW - Humans
KW - Magnetic Resonance Imaging
KW - Male
KW - Marfan Syndrome/complications
KW - Middle Aged
KW - Mitral Valve/physiopathology
KW - Mitral Valve Insufficiency/diagnosis
KW - Postoperative Complications/etiology
KW - Retrospective Studies
KW - Risk Factors
KW - Thoracotomy
KW - Time Factors
KW - Treatment Outcome
KW - Young Adult
U2 - 10.1055/s-0033-1348919
DO - 10.1055/s-0033-1348919
M3 - SCORING: Journal article
C2 - 23839872
VL - 62
SP - 35
EP - 41
JO - THORAC CARDIOV SURG
JF - THORAC CARDIOV SURG
SN - 0171-6425
IS - 1
ER -