Resting heart rate is an independent predictor of death in patients with colorectal, pancreatic, and non-small cell lung cancer: results of a prospective cardiovascular long-term study
Standard
Resting heart rate is an independent predictor of death in patients with colorectal, pancreatic, and non-small cell lung cancer: results of a prospective cardiovascular long-term study. / Anker, Markus S; Ebner, Nicole; Hildebrandt, Bert; Springer, Jochen; Sinn, Marianne; Riess, Hanno; Anker, Stefan D; Landmesser, Ulf; Haverkamp, Wilhelm; von Haehling, Stephan.
in: EUR J HEART FAIL, Jahrgang 18, Nr. 12, 12.2016, S. 1524-1534.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Resting heart rate is an independent predictor of death in patients with colorectal, pancreatic, and non-small cell lung cancer: results of a prospective cardiovascular long-term study
AU - Anker, Markus S
AU - Ebner, Nicole
AU - Hildebrandt, Bert
AU - Springer, Jochen
AU - Sinn, Marianne
AU - Riess, Hanno
AU - Anker, Stefan D
AU - Landmesser, Ulf
AU - Haverkamp, Wilhelm
AU - von Haehling, Stephan
N1 - © 2016 The Authors. European Journal of Heart Failure © 2016 European Society of Cardiology.
PY - 2016/12
Y1 - 2016/12
N2 - AIMS: Patients with advanced cancer have been shown to suffer from abnormal cardiac function and impaired exercise capacity that may contribute to their impaired quality of life. As tachycardia is considered as a sign of potential early cardiac damage, we sought to determine whether resting heart rate and other ECG-derived variables have prognostic value.METHODS AND RESULTS: From 2005 to 2010, we enrolled 145 patients with histologically confirmed cancer (36 colorectal, 72 pancreatic, and 37 non-small cell lung cancer patients) and 59 healthy controls. During a mean follow-up of 27 months, 82 patients (57%) died from any cause. The mean resting heart rate of healthy subjects was 70 ± 13 b.p.m., and that of cancer patients was 79 ± 14 b.p.m. (P< 0.0001). As a sensitivity analysis, we excluded control subjects taking a beta-blocker, but resting heart rate remained increased in cancer patients vs. controls (P < 0.0001). Resting heart rate ≥75 b.p.m. [hazard ratio (HR) 1.84, 95% confidence interval (CI) 1.16-2.94; P = 0.01] significantly predicted survival in univariable analyses and remained an independent predictor of survival in a multivariate model (HR 1.67, 95% CI 1.01-2.78; P = 0.04). Furthermore, the heart rate stayed significant in a second model that included age and sex as well.CONCLUSION: The present study is the first to show that resting heart rate independently of haemoglobin and tumour stage predicts survival in patients with advanced colorectal, pancreatic, and non-small cell lung cancer, and may therefore represent a therapeutic target.
AB - AIMS: Patients with advanced cancer have been shown to suffer from abnormal cardiac function and impaired exercise capacity that may contribute to their impaired quality of life. As tachycardia is considered as a sign of potential early cardiac damage, we sought to determine whether resting heart rate and other ECG-derived variables have prognostic value.METHODS AND RESULTS: From 2005 to 2010, we enrolled 145 patients with histologically confirmed cancer (36 colorectal, 72 pancreatic, and 37 non-small cell lung cancer patients) and 59 healthy controls. During a mean follow-up of 27 months, 82 patients (57%) died from any cause. The mean resting heart rate of healthy subjects was 70 ± 13 b.p.m., and that of cancer patients was 79 ± 14 b.p.m. (P< 0.0001). As a sensitivity analysis, we excluded control subjects taking a beta-blocker, but resting heart rate remained increased in cancer patients vs. controls (P < 0.0001). Resting heart rate ≥75 b.p.m. [hazard ratio (HR) 1.84, 95% confidence interval (CI) 1.16-2.94; P = 0.01] significantly predicted survival in univariable analyses and remained an independent predictor of survival in a multivariate model (HR 1.67, 95% CI 1.01-2.78; P = 0.04). Furthermore, the heart rate stayed significant in a second model that included age and sex as well.CONCLUSION: The present study is the first to show that resting heart rate independently of haemoglobin and tumour stage predicts survival in patients with advanced colorectal, pancreatic, and non-small cell lung cancer, and may therefore represent a therapeutic target.
KW - Aged
KW - Carcinoma, Non-Small-Cell Lung/mortality
KW - Case-Control Studies
KW - Cause of Death
KW - Colorectal Neoplasms/mortality
KW - Electrocardiography
KW - Female
KW - Follow-Up Studies
KW - Heart Rate
KW - Humans
KW - Lung Neoplasms/mortality
KW - Male
KW - Middle Aged
KW - Mortality
KW - Multivariate Analysis
KW - Pancreatic Neoplasms/mortality
KW - Prognosis
KW - Proportional Hazards Models
KW - Prospective Studies
KW - Survival Rate
U2 - 10.1002/ejhf.670
DO - 10.1002/ejhf.670
M3 - SCORING: Journal article
C2 - 27910284
VL - 18
SP - 1524
EP - 1534
JO - EUR J HEART FAIL
JF - EUR J HEART FAIL
SN - 1388-9842
IS - 12
ER -
