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Resistance to different classes of drugs is associated with impaired apoptosis in childhood acute lymphoblastic leukemia.

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Resistance to different classes of drugs is associated with impaired apoptosis in childhood acute lymphoblastic leukemia. / Holleman, Amy; Boer, den; Monique, L; Janka-Schaub, Gritta; Janka-Schaub, Gritta E; Pieters, Rob.

in: BLOOD, Jahrgang 102, Nr. 13, 13, 2003, S. 4541-4546.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Holleman, A, Boer, D, Monique, L, Janka-Schaub, G, Janka-Schaub, GE & Pieters, R 2003, 'Resistance to different classes of drugs is associated with impaired apoptosis in childhood acute lymphoblastic leukemia.', BLOOD, Jg. 102, Nr. 13, 13, S. 4541-4546. <http://www.ncbi.nlm.nih.gov/pubmed/12920041?dopt=Citation>

APA

Holleman, A., Boer, D., Monique, L., Janka-Schaub, G., Janka-Schaub, G. E., & Pieters, R. (2003). Resistance to different classes of drugs is associated with impaired apoptosis in childhood acute lymphoblastic leukemia. BLOOD, 102(13), 4541-4546. [13]. http://www.ncbi.nlm.nih.gov/pubmed/12920041?dopt=Citation

Vancouver

Holleman A, Boer D, Monique L, Janka-Schaub G, Janka-Schaub GE, Pieters R. Resistance to different classes of drugs is associated with impaired apoptosis in childhood acute lymphoblastic leukemia. BLOOD. 2003;102(13):4541-4546. 13.

Bibtex

@article{a27a052c6cef4cd4b38ddfc489887a0f,
title = "Resistance to different classes of drugs is associated with impaired apoptosis in childhood acute lymphoblastic leukemia.",
abstract = "Resistance of leukemic cells to chemotherapeutic agents is associated with an unfavorable outcome in pediatric acute lymphoblastic leukemia (ALL). To investigate the underlying mechanisms of cellular drug resistance, the activation of various apoptotic parameters in leukemic cells from 50 children with ALL was studied after in vitro exposure with 4 important drugs in ALL therapy (prednisolone, vincristine, l-asparaginase, and daunorubicin). Exposure to each drug resulted in early induction of phosphatidylserine (PS) externalization and mitochondrial transmembrane (Deltapsim) depolarization followed by caspase-3 activation and poly(ADP-ribose) polymerase (PARP) inactivation in the majority of patients. For all 4 drugs, a significant inverse correlation was found between cellular drug resistance and (1) the percentage of cells with PS externalization (",
author = "Amy Holleman and den Boer and L Monique and Gritta Janka-Schaub and Janka-Schaub, {Gritta E} and Rob Pieters",
year = "2003",
language = "Deutsch",
volume = "102",
pages = "4541--4546",
journal = "BLOOD",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "13",

}

RIS

TY - JOUR

T1 - Resistance to different classes of drugs is associated with impaired apoptosis in childhood acute lymphoblastic leukemia.

AU - Holleman, Amy

AU - Boer, den

AU - Monique, L

AU - Janka-Schaub, Gritta

AU - Janka-Schaub, Gritta E

AU - Pieters, Rob

PY - 2003

Y1 - 2003

N2 - Resistance of leukemic cells to chemotherapeutic agents is associated with an unfavorable outcome in pediatric acute lymphoblastic leukemia (ALL). To investigate the underlying mechanisms of cellular drug resistance, the activation of various apoptotic parameters in leukemic cells from 50 children with ALL was studied after in vitro exposure with 4 important drugs in ALL therapy (prednisolone, vincristine, l-asparaginase, and daunorubicin). Exposure to each drug resulted in early induction of phosphatidylserine (PS) externalization and mitochondrial transmembrane (Deltapsim) depolarization followed by caspase-3 activation and poly(ADP-ribose) polymerase (PARP) inactivation in the majority of patients. For all 4 drugs, a significant inverse correlation was found between cellular drug resistance and (1) the percentage of cells with PS externalization (

AB - Resistance of leukemic cells to chemotherapeutic agents is associated with an unfavorable outcome in pediatric acute lymphoblastic leukemia (ALL). To investigate the underlying mechanisms of cellular drug resistance, the activation of various apoptotic parameters in leukemic cells from 50 children with ALL was studied after in vitro exposure with 4 important drugs in ALL therapy (prednisolone, vincristine, l-asparaginase, and daunorubicin). Exposure to each drug resulted in early induction of phosphatidylserine (PS) externalization and mitochondrial transmembrane (Deltapsim) depolarization followed by caspase-3 activation and poly(ADP-ribose) polymerase (PARP) inactivation in the majority of patients. For all 4 drugs, a significant inverse correlation was found between cellular drug resistance and (1) the percentage of cells with PS externalization (

M3 - SCORING: Zeitschriftenaufsatz

VL - 102

SP - 4541

EP - 4546

JO - BLOOD

JF - BLOOD

SN - 0006-4971

IS - 13

M1 - 13

ER -