Requirement of peptidergic sensory innervation for disease activity in murine models of immune hepatitis and protection by beta-adrenergic stimulation.
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Requirement of peptidergic sensory innervation for disease activity in murine models of immune hepatitis and protection by beta-adrenergic stimulation. / Tiegs, Gisa; Bang, R; Neuhuber, W L.
in: J NEUROIMMUNOL, Jahrgang 96, Nr. 2, 2, 1999, S. 131-143.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Requirement of peptidergic sensory innervation for disease activity in murine models of immune hepatitis and protection by beta-adrenergic stimulation.
AU - Tiegs, Gisa
AU - Bang, R
AU - Neuhuber, W L
PY - 1999
Y1 - 1999
N2 - To investigate the interaction between the peripheral nervous and the immune system in vivo, we used two mouse models of T cell and TNF-alpha dependent liver injury inducible by either concanavalin A or a combination of D-galactosamine and staphylococcal enterotoxin B. Mice depleted of peptidergic sensory nerve fibres by capsaicin were protected from liver injury. Moreover, TNF-alpha production was significantly reduced. Examination of the effect of catecholamines on liver injury showed that the beta2-adrenergic agonist salbutamol prevented, whereas chemical sympathectomy by 6-hydroxydopamine, deteriorated the disease. Hence, strategies reducing the activity of peptidergic sensory nerve fibres or stimulating beta2-adrenoreceptors, may be of benefit in immune-mediated liver disease.
AB - To investigate the interaction between the peripheral nervous and the immune system in vivo, we used two mouse models of T cell and TNF-alpha dependent liver injury inducible by either concanavalin A or a combination of D-galactosamine and staphylococcal enterotoxin B. Mice depleted of peptidergic sensory nerve fibres by capsaicin were protected from liver injury. Moreover, TNF-alpha production was significantly reduced. Examination of the effect of catecholamines on liver injury showed that the beta2-adrenergic agonist salbutamol prevented, whereas chemical sympathectomy by 6-hydroxydopamine, deteriorated the disease. Hence, strategies reducing the activity of peptidergic sensory nerve fibres or stimulating beta2-adrenoreceptors, may be of benefit in immune-mediated liver disease.
KW - Animals
KW - Male
KW - Mice
KW - Mice, Inbred BALB C
KW - Capsaicin/pharmacology
KW - Adrenergic beta-Agonists/pharmacology
KW - Albuterol/pharmacology
KW - Catecholamines/physiology
KW - Hepatitis, Animal/pathology/physiopathology
KW - Immune System Diseases/physiopathology
KW - Liver/innervation/pathology
KW - Nerve Fibers/metabolism
KW - Neurons, Afferent/drug effects/physiology
KW - Receptors, Adrenergic, beta/physiology
KW - Sympathectomy, Chemical
KW - Animals
KW - Male
KW - Mice
KW - Mice, Inbred BALB C
KW - Capsaicin/pharmacology
KW - Adrenergic beta-Agonists/pharmacology
KW - Albuterol/pharmacology
KW - Catecholamines/physiology
KW - Hepatitis, Animal/pathology/physiopathology
KW - Immune System Diseases/physiopathology
KW - Liver/innervation/pathology
KW - Nerve Fibers/metabolism
KW - Neurons, Afferent/drug effects/physiology
KW - Receptors, Adrenergic, beta/physiology
KW - Sympathectomy, Chemical
M3 - SCORING: Journal article
VL - 96
SP - 131
EP - 143
JO - J NEUROIMMUNOL
JF - J NEUROIMMUNOL
SN - 0165-5728
IS - 2
M1 - 2
ER -
