Repair of radiation damage to DNA.
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Repair of radiation damage to DNA. / Willers, H; Dahm-Daphi, Jochen; Powell, S N.
in: BRIT J CANCER, Jahrgang 90, Nr. 7, 7, 2004, S. 1297-1301.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Repair of radiation damage to DNA.
AU - Willers, H
AU - Dahm-Daphi, Jochen
AU - Powell, S N
PY - 2004
Y1 - 2004
N2 - DNA double-strand breaks constitute the most dangerous type of DNA damage induced by ionising radiation (IR). Accordingly, the resistance of cells to IR is modulated by three intimately related cellular processes: DNA repair, recombination, and replication. Significant discoveries in this field of research have been made over the last few years. A picture seems to be emerging in which perturbations of recombination in cancer cells are a more widespread cause of genomic instability than previously appreciated. Conversely, such cells may also be more sensitive to certain chemotherapeutic drugs and to IR. Thus, the alterations in recombination that promote carcinogenesis by causing genomic instability may also be the weakness of the tumours that arise in this setting, a concept which could hold great promise for the advancement of cancer treatment in the not too distant future.
AB - DNA double-strand breaks constitute the most dangerous type of DNA damage induced by ionising radiation (IR). Accordingly, the resistance of cells to IR is modulated by three intimately related cellular processes: DNA repair, recombination, and replication. Significant discoveries in this field of research have been made over the last few years. A picture seems to be emerging in which perturbations of recombination in cancer cells are a more widespread cause of genomic instability than previously appreciated. Conversely, such cells may also be more sensitive to certain chemotherapeutic drugs and to IR. Thus, the alterations in recombination that promote carcinogenesis by causing genomic instability may also be the weakness of the tumours that arise in this setting, a concept which could hold great promise for the advancement of cancer treatment in the not too distant future.
M3 - SCORING: Zeitschriftenaufsatz
VL - 90
SP - 1297
EP - 1301
JO - BRIT J CANCER
JF - BRIT J CANCER
SN - 0007-0920
IS - 7
M1 - 7
ER -
