Remission in schizophrenia: validity, frequency, predictors, and patients' perspective 5 years later.
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Remission in schizophrenia: validity, frequency, predictors, and patients' perspective 5 years later. / Lambert, Martin; Karow, Anne; Leucht, Stefan; Schimmelmann, Benno G; Naber, Dieter.
in: DIALOGUES CLIN NEURO, Jahrgang 12, Nr. 3, 3, 2010, S. 393-407.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Remission in schizophrenia: validity, frequency, predictors, and patients' perspective 5 years later.
AU - Lambert, Martin
AU - Karow, Anne
AU - Leucht, Stefan
AU - Schimmelmann, Benno G
AU - Naber, Dieter
PY - 2010
Y1 - 2010
N2 - In March 2005, the Remission in Schizophrenia Working Group (RSWG) proposed a consensus definition of symptomatic remission in schizophrenia and developed specific operational criteria for its assessment. They pointed out, however, that the validity and the relationship to other outcome dimensions required further examination. This article reviews studies on the validity, frequency, and predictors of symptomatic remission in schizophrenia and studies on patients' perspectives. These studies have demonstrated that the RSWG remission criteria appear achievable and sustainable for a significant proportion of patients, and are related to a better overall symptomatic status and functional outcome and, to a less clear extent, to a better quality of life and cognitive performance. However, achieving symptomatic remission is not automatically concurrent with an adequate status in other outcome dimensions. The results of the present review suggest that the RSWG remission criteria are valid and useful. As such, they should be consistently applied in clinical trials. However the lack of consensus definitions of functional remission and adequate quality of life hampers research on their predictive validity on these outcome dimensions. Future research should therefore search for criteria of these dimensions and test whether the RSWG remission criteria consistently predict a "good" outcome with respect to functioning and quality of life.
AB - In March 2005, the Remission in Schizophrenia Working Group (RSWG) proposed a consensus definition of symptomatic remission in schizophrenia and developed specific operational criteria for its assessment. They pointed out, however, that the validity and the relationship to other outcome dimensions required further examination. This article reviews studies on the validity, frequency, and predictors of symptomatic remission in schizophrenia and studies on patients' perspectives. These studies have demonstrated that the RSWG remission criteria appear achievable and sustainable for a significant proportion of patients, and are related to a better overall symptomatic status and functional outcome and, to a less clear extent, to a better quality of life and cognitive performance. However, achieving symptomatic remission is not automatically concurrent with an adequate status in other outcome dimensions. The results of the present review suggest that the RSWG remission criteria are valid and useful. As such, they should be consistently applied in clinical trials. However the lack of consensus definitions of functional remission and adequate quality of life hampers research on their predictive validity on these outcome dimensions. Future research should therefore search for criteria of these dimensions and test whether the RSWG remission criteria consistently predict a "good" outcome with respect to functioning and quality of life.
M3 - SCORING: Zeitschriftenaufsatz
VL - 12
SP - 393
EP - 407
JO - DIALOGUES CLIN NEURO
JF - DIALOGUES CLIN NEURO
SN - 1294-8322
IS - 3
M1 - 3
ER -
