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Regulatory CD4+CD25+ T cells restrict memory CD8+ T cell responses

Standard

Regulatory CD4+CD25+ T cells restrict memory CD8+ T cell responses. / Kursar, Mischo; Bonhagen, Kerstin; Fensterle, Joachim; Köhler, Anne; Hurwitz, Robert; Kamradt, Thomas; Kaufmann, Stefan H E; Mittrücker, Hans-Willi.

in: J EXP MED, Jahrgang 196, Nr. 12, 16.12.2002, S. 1585-92.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kursar, M, Bonhagen, K, Fensterle, J, Köhler, A, Hurwitz, R, Kamradt, T, Kaufmann, SHE & Mittrücker, H-W 2002, 'Regulatory CD4+CD25+ T cells restrict memory CD8+ T cell responses', J EXP MED, Jg. 196, Nr. 12, S. 1585-92.

APA

Kursar, M., Bonhagen, K., Fensterle, J., Köhler, A., Hurwitz, R., Kamradt, T., Kaufmann, S. H. E., & Mittrücker, H-W. (2002). Regulatory CD4+CD25+ T cells restrict memory CD8+ T cell responses. J EXP MED, 196(12), 1585-92.

Vancouver

Kursar M, Bonhagen K, Fensterle J, Köhler A, Hurwitz R, Kamradt T et al. Regulatory CD4+CD25+ T cells restrict memory CD8+ T cell responses. J EXP MED. 2002 Dez 16;196(12):1585-92.

Bibtex

@article{e22b387353fd41668ac530d098d83728,
title = "Regulatory CD4+CD25+ T cells restrict memory CD8+ T cell responses",
abstract = "CD4+ T cell help is important for the generation of CD8+ T cell responses. We used depleting anti-CD4 mAb to analyze the role of CD4+ T cells for memory CD8+ T cell responses after secondary infection of mice with the intracellular bacterium Listeria monocytogenes, or after boost immunization by specific peptide or DNA vaccination. Surprisingly, anti-CD4 mAb treatment during secondary CD8+ T cell responses markedly enlarged the population size of antigen-specific CD8+ T cells. After boost immunization with peptide or DNA, this effect was particularly profound, and antigen-specific CD8+ T cell populations were enlarged at least 10-fold. In terms of cytokine production and cytotoxicity, the enlarged CD8+ T cell population consisted of functional effector T cells. In depletion and transfer experiments, the suppressive function could be ascribed to CD4+CD25+ T cells. Our results demonstrate that CD4+ T cells control the CD8+ T cell response in two directions. Initially, they promote the generation of a CD8+ T cell responses and later they restrain the strength of the CD8+ T cell memory response. Down-modulation of CD8+ T cell responses during infection could prevent harmful consequences after eradication of the pathogen.",
keywords = "Adoptive Transfer, Animals, Antibodies, Monoclonal, Bacterial Vaccines, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Immunization, Secondary, Immunologic Memory, Listeria monocytogenes, Listeriosis, Lymphocyte Activation, Lymphocyte Depletion, Mice, Mice, Inbred BALB C, Mice, SCID, Peptides, Receptors, Interleukin-2, Spleen, Vaccination, Vaccines, DNA",
author = "Mischo Kursar and Kerstin Bonhagen and Joachim Fensterle and Anne K{\"o}hler and Robert Hurwitz and Thomas Kamradt and Kaufmann, {Stefan H E} and Hans-Willi Mittr{\"u}cker",
year = "2002",
month = dec,
day = "16",
language = "English",
volume = "196",
pages = "1585--92",
journal = "J EXP MED",
issn = "0022-1007",
publisher = "Rockefeller University Press",
number = "12",

}

RIS

TY - JOUR

T1 - Regulatory CD4+CD25+ T cells restrict memory CD8+ T cell responses

AU - Kursar, Mischo

AU - Bonhagen, Kerstin

AU - Fensterle, Joachim

AU - Köhler, Anne

AU - Hurwitz, Robert

AU - Kamradt, Thomas

AU - Kaufmann, Stefan H E

AU - Mittrücker, Hans-Willi

PY - 2002/12/16

Y1 - 2002/12/16

N2 - CD4+ T cell help is important for the generation of CD8+ T cell responses. We used depleting anti-CD4 mAb to analyze the role of CD4+ T cells for memory CD8+ T cell responses after secondary infection of mice with the intracellular bacterium Listeria monocytogenes, or after boost immunization by specific peptide or DNA vaccination. Surprisingly, anti-CD4 mAb treatment during secondary CD8+ T cell responses markedly enlarged the population size of antigen-specific CD8+ T cells. After boost immunization with peptide or DNA, this effect was particularly profound, and antigen-specific CD8+ T cell populations were enlarged at least 10-fold. In terms of cytokine production and cytotoxicity, the enlarged CD8+ T cell population consisted of functional effector T cells. In depletion and transfer experiments, the suppressive function could be ascribed to CD4+CD25+ T cells. Our results demonstrate that CD4+ T cells control the CD8+ T cell response in two directions. Initially, they promote the generation of a CD8+ T cell responses and later they restrain the strength of the CD8+ T cell memory response. Down-modulation of CD8+ T cell responses during infection could prevent harmful consequences after eradication of the pathogen.

AB - CD4+ T cell help is important for the generation of CD8+ T cell responses. We used depleting anti-CD4 mAb to analyze the role of CD4+ T cells for memory CD8+ T cell responses after secondary infection of mice with the intracellular bacterium Listeria monocytogenes, or after boost immunization by specific peptide or DNA vaccination. Surprisingly, anti-CD4 mAb treatment during secondary CD8+ T cell responses markedly enlarged the population size of antigen-specific CD8+ T cells. After boost immunization with peptide or DNA, this effect was particularly profound, and antigen-specific CD8+ T cell populations were enlarged at least 10-fold. In terms of cytokine production and cytotoxicity, the enlarged CD8+ T cell population consisted of functional effector T cells. In depletion and transfer experiments, the suppressive function could be ascribed to CD4+CD25+ T cells. Our results demonstrate that CD4+ T cells control the CD8+ T cell response in two directions. Initially, they promote the generation of a CD8+ T cell responses and later they restrain the strength of the CD8+ T cell memory response. Down-modulation of CD8+ T cell responses during infection could prevent harmful consequences after eradication of the pathogen.

KW - Adoptive Transfer

KW - Animals

KW - Antibodies, Monoclonal

KW - Bacterial Vaccines

KW - CD4-Positive T-Lymphocytes

KW - CD8-Positive T-Lymphocytes

KW - Immunization, Secondary

KW - Immunologic Memory

KW - Listeria monocytogenes

KW - Listeriosis

KW - Lymphocyte Activation

KW - Lymphocyte Depletion

KW - Mice

KW - Mice, Inbred BALB C

KW - Mice, SCID

KW - Peptides

KW - Receptors, Interleukin-2

KW - Spleen

KW - Vaccination

KW - Vaccines, DNA

M3 - SCORING: Journal article

C2 - 12486101

VL - 196

SP - 1585

EP - 1592

JO - J EXP MED

JF - J EXP MED

SN - 0022-1007

IS - 12

ER -