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Regulation of the renin-angiotensin-aldosterone system by cyclic nucleotides and phosphodiesterases

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Regulation of the renin-angiotensin-aldosterone system by cyclic nucleotides and phosphodiesterases. / Gambaryan, Stepan; Mohagaonkar, Sanika; Nikolaev, Viacheslav O.

in: FRONT ENDOCRINOL, Jahrgang 14, 2023, S. 1239492.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Gambaryan, S, Mohagaonkar, S & Nikolaev, VO 2023, 'Regulation of the renin-angiotensin-aldosterone system by cyclic nucleotides and phosphodiesterases', FRONT ENDOCRINOL, Jg. 14, S. 1239492. https://doi.org/10.3389/fendo.2023.1239492

APA

Gambaryan, S., Mohagaonkar, S., & Nikolaev, V. O. (2023). Regulation of the renin-angiotensin-aldosterone system by cyclic nucleotides and phosphodiesterases. FRONT ENDOCRINOL, 14, 1239492. https://doi.org/10.3389/fendo.2023.1239492

Vancouver

Gambaryan S, Mohagaonkar S, Nikolaev VO. Regulation of the renin-angiotensin-aldosterone system by cyclic nucleotides and phosphodiesterases. FRONT ENDOCRINOL. 2023;14:1239492. https://doi.org/10.3389/fendo.2023.1239492

Bibtex

@article{19ad18dbef1f41e680ab809e9632528e,
title = "Regulation of the renin-angiotensin-aldosterone system by cyclic nucleotides and phosphodiesterases",
abstract = "The renin-angiotensin-aldosterone system (RAAS) is one of the key players in the regulation of blood volume and blood pressure. Dysfunction of this system is connected with cardiovascular and renal diseases. Regulation of RAAS is under the control of multiple intracellular mechanisms. Cyclic nucleotides and phosphodiesterases are the major regulators of this system since they control expression and activity of renin and aldosterone. In this review, we summarize known mechanisms by which cyclic nucleotides and phosphodiesterases regulate renin gene expression, secretion of renin granules from juxtaglomerular cells and aldosterone production from zona glomerulosa cells of adrenal gland. We also discuss several open questions which deserve future attention.",
keywords = "Renin-Angiotensin System, Renin, Aldosterone, Nucleotides, Cyclic, Phosphoric Diester Hydrolases",
author = "Stepan Gambaryan and Sanika Mohagaonkar and Nikolaev, {Viacheslav O}",
note = "Copyright {\textcopyright} 2023 Gambaryan, Mohagaonkar and Nikolaev.",
year = "2023",
doi = "10.3389/fendo.2023.1239492",
language = "English",
volume = "14",
pages = "1239492",
journal = "FRONT ENDOCRINOL",
issn = "1664-2392",
publisher = "Frontiers Media S. A.",

}

RIS

TY - JOUR

T1 - Regulation of the renin-angiotensin-aldosterone system by cyclic nucleotides and phosphodiesterases

AU - Gambaryan, Stepan

AU - Mohagaonkar, Sanika

AU - Nikolaev, Viacheslav O

N1 - Copyright © 2023 Gambaryan, Mohagaonkar and Nikolaev.

PY - 2023

Y1 - 2023

N2 - The renin-angiotensin-aldosterone system (RAAS) is one of the key players in the regulation of blood volume and blood pressure. Dysfunction of this system is connected with cardiovascular and renal diseases. Regulation of RAAS is under the control of multiple intracellular mechanisms. Cyclic nucleotides and phosphodiesterases are the major regulators of this system since they control expression and activity of renin and aldosterone. In this review, we summarize known mechanisms by which cyclic nucleotides and phosphodiesterases regulate renin gene expression, secretion of renin granules from juxtaglomerular cells and aldosterone production from zona glomerulosa cells of adrenal gland. We also discuss several open questions which deserve future attention.

AB - The renin-angiotensin-aldosterone system (RAAS) is one of the key players in the regulation of blood volume and blood pressure. Dysfunction of this system is connected with cardiovascular and renal diseases. Regulation of RAAS is under the control of multiple intracellular mechanisms. Cyclic nucleotides and phosphodiesterases are the major regulators of this system since they control expression and activity of renin and aldosterone. In this review, we summarize known mechanisms by which cyclic nucleotides and phosphodiesterases regulate renin gene expression, secretion of renin granules from juxtaglomerular cells and aldosterone production from zona glomerulosa cells of adrenal gland. We also discuss several open questions which deserve future attention.

KW - Renin-Angiotensin System

KW - Renin

KW - Aldosterone

KW - Nucleotides, Cyclic

KW - Phosphoric Diester Hydrolases

U2 - 10.3389/fendo.2023.1239492

DO - 10.3389/fendo.2023.1239492

M3 - SCORING: Review article

C2 - 37674612

VL - 14

SP - 1239492

JO - FRONT ENDOCRINOL

JF - FRONT ENDOCRINOL

SN - 1664-2392

ER -