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Regulation of pregnancy maintenance and fetal survival in mice by CD27(low) mature NK cells.

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Regulation of pregnancy maintenance and fetal survival in mice by CD27(low) mature NK cells. / Karimi, Khalil; Solano, Maria Emilia; Ashkar, Ali A; Ho, Huang; Steidle, Eva-Maria; Karen-Anne, McVey Neufeld; Hecher, Kurt; Bienenstock, John; Arck, Petra.

in: J MOL MED, Jahrgang 90, Nr. 9, 9, 2012, S. 1047-1057.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Karimi, K, Solano, ME, Ashkar, AA, Ho, H, Steidle, E-M, Karen-Anne, MN, Hecher, K, Bienenstock, J & Arck, P 2012, 'Regulation of pregnancy maintenance and fetal survival in mice by CD27(low) mature NK cells.', J MOL MED, Jg. 90, Nr. 9, 9, S. 1047-1057. https://doi.org/10.1007/s00109-012-0872-5

APA

Karimi, K., Solano, M. E., Ashkar, A. A., Ho, H., Steidle, E-M., Karen-Anne, M. N., Hecher, K., Bienenstock, J., & Arck, P. (2012). Regulation of pregnancy maintenance and fetal survival in mice by CD27(low) mature NK cells. J MOL MED, 90(9), 1047-1057. [9]. https://doi.org/10.1007/s00109-012-0872-5

Vancouver

Karimi K, Solano ME, Ashkar AA, Ho H, Steidle E-M, Karen-Anne MN et al. Regulation of pregnancy maintenance and fetal survival in mice by CD27(low) mature NK cells. J MOL MED. 2012;90(9):1047-1057. 9. https://doi.org/10.1007/s00109-012-0872-5

Bibtex

@article{f257d833ef0049a8a98cfd6c7854cc78,
title = "Regulation of pregnancy maintenance and fetal survival in mice by CD27(low) mature NK cells.",
abstract = "Uterine natural killer (NK) cells are pivotal for successful mammalian reproduction. However, insights on functionally distinct subpopulations of uterine NK cells are largely elusive. Furthermore, translation of findings from murine into human pregnancy has been overshadowed by the limited number of mutual phenotypic NK cell markers. We here provide evidence that a subset of murine mature NK (mNK) cells present at the feto-maternal interface, identified as CD27(low)DX5(+)CD3(neg), is pivotal in maintaining pregnancy. This mNK subset has low cytotoxic capacity, produces higher amounts of interferon (IFN)-?, and expresses functional homologs of human NK cell immunoglobulin-like receptors. We further show that bone marrow-derived CD27(low) mNK cells are selectively recruited to the uterus and ameliorate the rate of fetal loss when adoptively transferred into alymphoid RAG2(-/-)/?c(-/-) mice. Additionally, expression of CD27 is down-modulated on mNK cells upon migration to the uterus. Hence, we propose the existence of a regulatory mNK cell subset, which is licensed toward successful pregnancy maintenance at the fetomaternal interface in mice. As CD27(low) NK cells are also present in human decidua, the CD27(low) NK subset may provide a tool to foster translational research in reproduction, aiming to improve pregnancy outcome in humans.",
keywords = "Animals, Humans, Male, Female, Mice, Mice, Inbred BALB C, Pregnancy, Interferon-gamma/immunology, *Pregnancy Maintenance, Antigens, CD27/*immunology, Killer Cells, Natural/*immunology, Poly I-C/immunology, Uterus/immunology, Animals, Humans, Male, Female, Mice, Mice, Inbred BALB C, Pregnancy, Interferon-gamma/immunology, *Pregnancy Maintenance, Antigens, CD27/*immunology, Killer Cells, Natural/*immunology, Poly I-C/immunology, Uterus/immunology",
author = "Khalil Karimi and Solano, {Maria Emilia} and Ashkar, {Ali A} and Huang Ho and Eva-Maria Steidle and Karen-Anne, {McVey Neufeld} and Kurt Hecher and John Bienenstock and Petra Arck",
year = "2012",
doi = "10.1007/s00109-012-0872-5",
language = "English",
volume = "90",
pages = "1047--1057",
journal = "J MOL MED",
issn = "0946-2716",
publisher = "Springer",
number = "9",

}

RIS

TY - JOUR

T1 - Regulation of pregnancy maintenance and fetal survival in mice by CD27(low) mature NK cells.

AU - Karimi, Khalil

AU - Solano, Maria Emilia

AU - Ashkar, Ali A

AU - Ho, Huang

AU - Steidle, Eva-Maria

AU - Karen-Anne, McVey Neufeld

AU - Hecher, Kurt

AU - Bienenstock, John

AU - Arck, Petra

PY - 2012

Y1 - 2012

N2 - Uterine natural killer (NK) cells are pivotal for successful mammalian reproduction. However, insights on functionally distinct subpopulations of uterine NK cells are largely elusive. Furthermore, translation of findings from murine into human pregnancy has been overshadowed by the limited number of mutual phenotypic NK cell markers. We here provide evidence that a subset of murine mature NK (mNK) cells present at the feto-maternal interface, identified as CD27(low)DX5(+)CD3(neg), is pivotal in maintaining pregnancy. This mNK subset has low cytotoxic capacity, produces higher amounts of interferon (IFN)-?, and expresses functional homologs of human NK cell immunoglobulin-like receptors. We further show that bone marrow-derived CD27(low) mNK cells are selectively recruited to the uterus and ameliorate the rate of fetal loss when adoptively transferred into alymphoid RAG2(-/-)/?c(-/-) mice. Additionally, expression of CD27 is down-modulated on mNK cells upon migration to the uterus. Hence, we propose the existence of a regulatory mNK cell subset, which is licensed toward successful pregnancy maintenance at the fetomaternal interface in mice. As CD27(low) NK cells are also present in human decidua, the CD27(low) NK subset may provide a tool to foster translational research in reproduction, aiming to improve pregnancy outcome in humans.

AB - Uterine natural killer (NK) cells are pivotal for successful mammalian reproduction. However, insights on functionally distinct subpopulations of uterine NK cells are largely elusive. Furthermore, translation of findings from murine into human pregnancy has been overshadowed by the limited number of mutual phenotypic NK cell markers. We here provide evidence that a subset of murine mature NK (mNK) cells present at the feto-maternal interface, identified as CD27(low)DX5(+)CD3(neg), is pivotal in maintaining pregnancy. This mNK subset has low cytotoxic capacity, produces higher amounts of interferon (IFN)-?, and expresses functional homologs of human NK cell immunoglobulin-like receptors. We further show that bone marrow-derived CD27(low) mNK cells are selectively recruited to the uterus and ameliorate the rate of fetal loss when adoptively transferred into alymphoid RAG2(-/-)/?c(-/-) mice. Additionally, expression of CD27 is down-modulated on mNK cells upon migration to the uterus. Hence, we propose the existence of a regulatory mNK cell subset, which is licensed toward successful pregnancy maintenance at the fetomaternal interface in mice. As CD27(low) NK cells are also present in human decidua, the CD27(low) NK subset may provide a tool to foster translational research in reproduction, aiming to improve pregnancy outcome in humans.

KW - Animals

KW - Humans

KW - Male

KW - Female

KW - Mice

KW - Mice, Inbred BALB C

KW - Pregnancy

KW - Interferon-gamma/immunology

KW - Pregnancy Maintenance

KW - Antigens, CD27/immunology

KW - Killer Cells, Natural/immunology

KW - Poly I-C/immunology

KW - Uterus/immunology

KW - Animals

KW - Humans

KW - Male

KW - Female

KW - Mice

KW - Mice, Inbred BALB C

KW - Pregnancy

KW - Interferon-gamma/immunology

KW - Pregnancy Maintenance

KW - Antigens, CD27/immunology

KW - Killer Cells, Natural/immunology

KW - Poly I-C/immunology

KW - Uterus/immunology

U2 - 10.1007/s00109-012-0872-5

DO - 10.1007/s00109-012-0872-5

M3 - SCORING: Journal article

VL - 90

SP - 1047

EP - 1057

JO - J MOL MED

JF - J MOL MED

SN - 0946-2716

IS - 9

M1 - 9

ER -