Regulation of Eicosanoid Pathways by MicroRNAs

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Regulation of Eicosanoid Pathways by MicroRNAs. / Saul, Meike J; Emmerich, Anne C; Steinhilber, Dieter; Suess, Beatrix.

in: FRONT PHARMACOL, Jahrgang 10, 2019, S. 824.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ReviewForschung

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@article{84612a4cfd454f099b3aa30198c25f40,
title = "Regulation of Eicosanoid Pathways by MicroRNAs",
abstract = "Over the last years, many microRNAs (miRNAs) have been identified that regulate the formation of bioactive lipid mediators such as prostanoids and leukotrienes. Many of these miRNAs are involved in complex regulatory circuits necessary for the fine-tuning of biological functions including inflammatory processes or cell growth. A better understanding of these networks will contribute to the development of novel therapeutic strategies for the treatment of inflammatory diseases and cancer. In this review, we provide an overview of the current knowledge of miRNA regulation in eicosanoid pathways with special focus on novel miRNA functions and regulatory circuits of leukotriene and prostaglandin biosynthesis.",
author = "Saul, {Meike J} and Emmerich, {Anne C} and Dieter Steinhilber and Beatrix Suess",
year = "2019",
doi = "10.3389/fphar.2019.00824",
language = "English",
volume = "10",
pages = "824",
journal = "FRONT PHARMACOL",
issn = "1663-9812",
publisher = "Frontiers Media S. A.",

}

RIS

TY - JOUR

T1 - Regulation of Eicosanoid Pathways by MicroRNAs

AU - Saul, Meike J

AU - Emmerich, Anne C

AU - Steinhilber, Dieter

AU - Suess, Beatrix

PY - 2019

Y1 - 2019

N2 - Over the last years, many microRNAs (miRNAs) have been identified that regulate the formation of bioactive lipid mediators such as prostanoids and leukotrienes. Many of these miRNAs are involved in complex regulatory circuits necessary for the fine-tuning of biological functions including inflammatory processes or cell growth. A better understanding of these networks will contribute to the development of novel therapeutic strategies for the treatment of inflammatory diseases and cancer. In this review, we provide an overview of the current knowledge of miRNA regulation in eicosanoid pathways with special focus on novel miRNA functions and regulatory circuits of leukotriene and prostaglandin biosynthesis.

AB - Over the last years, many microRNAs (miRNAs) have been identified that regulate the formation of bioactive lipid mediators such as prostanoids and leukotrienes. Many of these miRNAs are involved in complex regulatory circuits necessary for the fine-tuning of biological functions including inflammatory processes or cell growth. A better understanding of these networks will contribute to the development of novel therapeutic strategies for the treatment of inflammatory diseases and cancer. In this review, we provide an overview of the current knowledge of miRNA regulation in eicosanoid pathways with special focus on novel miRNA functions and regulatory circuits of leukotriene and prostaglandin biosynthesis.

U2 - 10.3389/fphar.2019.00824

DO - 10.3389/fphar.2019.00824

M3 - SCORING: Review article

C2 - 31379585

VL - 10

SP - 824

JO - FRONT PHARMACOL

JF - FRONT PHARMACOL

SN - 1663-9812

ER -