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Regional IFNgamma expression is insufficient for efficacious control of food-borne bacterial pathogens at the gut epithelial barrier.

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Regional IFNgamma expression is insufficient for efficacious control of food-borne bacterial pathogens at the gut epithelial barrier. / Gajendran, Nadesan; Mittrücker, Hans Willi; Bordasch, Karin; Heinemann, Ellen; Koch, Markus; Kaufmann, Stefan H E.

in: INT IMMUNOL, Jahrgang 19, Nr. 9, 9, 2007, S. 1075-1081.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Gajendran, N, Mittrücker, HW, Bordasch, K, Heinemann, E, Koch, M & Kaufmann, SHE 2007, 'Regional IFNgamma expression is insufficient for efficacious control of food-borne bacterial pathogens at the gut epithelial barrier.', INT IMMUNOL, Jg. 19, Nr. 9, 9, S. 1075-1081. <http://www.ncbi.nlm.nih.gov/pubmed/17698562?dopt=Citation>

APA

Gajendran, N., Mittrücker, H. W., Bordasch, K., Heinemann, E., Koch, M., & Kaufmann, S. H. E. (2007). Regional IFNgamma expression is insufficient for efficacious control of food-borne bacterial pathogens at the gut epithelial barrier. INT IMMUNOL, 19(9), 1075-1081. [9]. http://www.ncbi.nlm.nih.gov/pubmed/17698562?dopt=Citation

Vancouver

Gajendran N, Mittrücker HW, Bordasch K, Heinemann E, Koch M, Kaufmann SHE. Regional IFNgamma expression is insufficient for efficacious control of food-borne bacterial pathogens at the gut epithelial barrier. INT IMMUNOL. 2007;19(9):1075-1081. 9.

Bibtex

@article{22499e3ff4c941a4ab8b1041c0d73243,
title = "Regional IFNgamma expression is insufficient for efficacious control of food-borne bacterial pathogens at the gut epithelial barrier.",
abstract = "IFNgamma is critical for host defence against various food-borne pathogens including Salmonella enterica and Listeria monocytogenes, the causative agents of salmonellosis and listeriosis, respectively. We investigated the impact of regional IFNgamma expression at the intestinal epithelial barrier on host invasion by salmonellae and listeriae following oral challenge. Transgenic mice (IFNgamma-gut), generated on an IFNgamma knock-out (KO) background, selectively expressed IFNgamma in the gut driven by the modified liver fatty acid-binding protein (Fabpl(4x at -132)) promoter. Infections with attenuated S. enterica Typhimurium or with L. monocytogenes did not differ significantly in IFNgamma-KO, IFNgamma-gut and wild-type mice. Further, Listeria-specific CD4+ and CD8+ T cells were not altered in IFNgamma-gut mice. Thus, this model indicates that local IFNgamma expression by non-immunological cells in the distal part of the small intestine, caecum and colon is insufficient for prevention of gut penetration by S. enterica Typhimurium and L. monocytogenes.",
author = "Nadesan Gajendran and Mittr{\"u}cker, {Hans Willi} and Karin Bordasch and Ellen Heinemann and Markus Koch and Kaufmann, {Stefan H E}",
year = "2007",
language = "Deutsch",
volume = "19",
pages = "1075--1081",
journal = "INT IMMUNOL",
issn = "0953-8178",
publisher = "Oxford University Press",
number = "9",

}

RIS

TY - JOUR

T1 - Regional IFNgamma expression is insufficient for efficacious control of food-borne bacterial pathogens at the gut epithelial barrier.

AU - Gajendran, Nadesan

AU - Mittrücker, Hans Willi

AU - Bordasch, Karin

AU - Heinemann, Ellen

AU - Koch, Markus

AU - Kaufmann, Stefan H E

PY - 2007

Y1 - 2007

N2 - IFNgamma is critical for host defence against various food-borne pathogens including Salmonella enterica and Listeria monocytogenes, the causative agents of salmonellosis and listeriosis, respectively. We investigated the impact of regional IFNgamma expression at the intestinal epithelial barrier on host invasion by salmonellae and listeriae following oral challenge. Transgenic mice (IFNgamma-gut), generated on an IFNgamma knock-out (KO) background, selectively expressed IFNgamma in the gut driven by the modified liver fatty acid-binding protein (Fabpl(4x at -132)) promoter. Infections with attenuated S. enterica Typhimurium or with L. monocytogenes did not differ significantly in IFNgamma-KO, IFNgamma-gut and wild-type mice. Further, Listeria-specific CD4+ and CD8+ T cells were not altered in IFNgamma-gut mice. Thus, this model indicates that local IFNgamma expression by non-immunological cells in the distal part of the small intestine, caecum and colon is insufficient for prevention of gut penetration by S. enterica Typhimurium and L. monocytogenes.

AB - IFNgamma is critical for host defence against various food-borne pathogens including Salmonella enterica and Listeria monocytogenes, the causative agents of salmonellosis and listeriosis, respectively. We investigated the impact of regional IFNgamma expression at the intestinal epithelial barrier on host invasion by salmonellae and listeriae following oral challenge. Transgenic mice (IFNgamma-gut), generated on an IFNgamma knock-out (KO) background, selectively expressed IFNgamma in the gut driven by the modified liver fatty acid-binding protein (Fabpl(4x at -132)) promoter. Infections with attenuated S. enterica Typhimurium or with L. monocytogenes did not differ significantly in IFNgamma-KO, IFNgamma-gut and wild-type mice. Further, Listeria-specific CD4+ and CD8+ T cells were not altered in IFNgamma-gut mice. Thus, this model indicates that local IFNgamma expression by non-immunological cells in the distal part of the small intestine, caecum and colon is insufficient for prevention of gut penetration by S. enterica Typhimurium and L. monocytogenes.

M3 - SCORING: Zeitschriftenaufsatz

VL - 19

SP - 1075

EP - 1081

JO - INT IMMUNOL

JF - INT IMMUNOL

SN - 0953-8178

IS - 9

M1 - 9

ER -