Regional diastolic and systolic function by strain rate imaging for the detection of intramural viability during dobutamine stress echocardiography in a porcine model of myocardial infarction.
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Regional diastolic and systolic function by strain rate imaging for the detection of intramural viability during dobutamine stress echocardiography in a porcine model of myocardial infarction. / Schneider, Carsten; Jaquet, Kai; Geidel, Stephan; Malisius, Rainer; Boczor, Sigrid; Rau, Thomas; Zienkiewicz, Tomacz; Hennig, Detlef; Kuck, Karl-Heinz; Krause, Korff.
in: ECHOCARDIOGR-J CARD, Jahrgang 27, Nr. 5, 5, 2010, S. 552-562.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Regional diastolic and systolic function by strain rate imaging for the detection of intramural viability during dobutamine stress echocardiography in a porcine model of myocardial infarction.
AU - Schneider, Carsten
AU - Jaquet, Kai
AU - Geidel, Stephan
AU - Malisius, Rainer
AU - Boczor, Sigrid
AU - Rau, Thomas
AU - Zienkiewicz, Tomacz
AU - Hennig, Detlef
AU - Kuck, Karl-Heinz
AU - Krause, Korff
PY - 2010
Y1 - 2010
N2 - The aim of this study was to evaluate diastolic and systolic strain rate measurements for differentiation of transmural/nontransmural infarction during dobutamine stress echocardiography (DSE). An ameroid constrictor was placed around the circumflex artery in 23 pigs inducing chronic vessel occlusion. Five pigs without constrictor served as controls. During high-dose DSE systolic strain rates (SR(sys)), systolic and postsystolic strain values (epsilon(sys), epsilon(ps)) and early and late diastolic strain rates (SR(E) and SR(A)) were determined. At week 6, animals were evaluated regarding myocardial fibrosis. Histology revealed nontransmural in 14 and transmural infarction in 9 animals. In controls, dobutamine induced a linear increase of SR(sys) to 12.3 + or - 0.4 s(-1) at 40 microg/kg per minute (P = 0.001) and a linear decrease of SR(E) to -6.6 + or - 0.3 s(-1) (P = 0.001). In the nontransmural group, SR(sys), epsilon(sys), epsilon(ps) at rest, and during DSE were higher and SR(E) was lower than in the transmural infarction group (P = 0.01). Best predictors for viability were SR(sys) (ROC 0.96, P = 0.0003), SR(E) at 10 microg/kg per minute dobutamine stimulation (ROC 0.94, P = 0.001) and positive SR values during isovolumetric relaxation at 40 microg/kg per minute dobutamine (ROC 0.86, P = 0.004). The extension of fibrosis correlated with SR(sys) at rest, epsilon(sys) at rest, and SR(E) at rest (P <0.001). For the detection of viability similar diagnostic accuracies of SR(E) and SRsys were seen (sensitivity 93%/93%, specificity 96%/94%, respectively). Diastolic SR analysis seems to be equipotent for the identification of viable myocardium in comparison to systolic SR parameters and allows the differentiation of nontransmural from transmural myocardial infarction with high diagnostic accuracy. (Echocardiography 2010;27:552-562).
AB - The aim of this study was to evaluate diastolic and systolic strain rate measurements for differentiation of transmural/nontransmural infarction during dobutamine stress echocardiography (DSE). An ameroid constrictor was placed around the circumflex artery in 23 pigs inducing chronic vessel occlusion. Five pigs without constrictor served as controls. During high-dose DSE systolic strain rates (SR(sys)), systolic and postsystolic strain values (epsilon(sys), epsilon(ps)) and early and late diastolic strain rates (SR(E) and SR(A)) were determined. At week 6, animals were evaluated regarding myocardial fibrosis. Histology revealed nontransmural in 14 and transmural infarction in 9 animals. In controls, dobutamine induced a linear increase of SR(sys) to 12.3 + or - 0.4 s(-1) at 40 microg/kg per minute (P = 0.001) and a linear decrease of SR(E) to -6.6 + or - 0.3 s(-1) (P = 0.001). In the nontransmural group, SR(sys), epsilon(sys), epsilon(ps) at rest, and during DSE were higher and SR(E) was lower than in the transmural infarction group (P = 0.01). Best predictors for viability were SR(sys) (ROC 0.96, P = 0.0003), SR(E) at 10 microg/kg per minute dobutamine stimulation (ROC 0.94, P = 0.001) and positive SR values during isovolumetric relaxation at 40 microg/kg per minute dobutamine (ROC 0.86, P = 0.004). The extension of fibrosis correlated with SR(sys) at rest, epsilon(sys) at rest, and SR(E) at rest (P <0.001). For the detection of viability similar diagnostic accuracies of SR(E) and SRsys were seen (sensitivity 93%/93%, specificity 96%/94%, respectively). Diastolic SR analysis seems to be equipotent for the identification of viable myocardium in comparison to systolic SR parameters and allows the differentiation of nontransmural from transmural myocardial infarction with high diagnostic accuracy. (Echocardiography 2010;27:552-562).
KW - Animals
KW - ROC Curve
KW - Myocardial Infarction pathology
KW - Image Processing, Computer-Assisted
KW - Statistics, Nonparametric
KW - Swine
KW - Linear Models
KW - Diastole
KW - Dobutamine diagnostic use
KW - Echocardiography, Stress methods
KW - Fibrosis ultrasonography
KW - Systole
KW - Animals
KW - ROC Curve
KW - Myocardial Infarction pathology
KW - Image Processing, Computer-Assisted
KW - Statistics, Nonparametric
KW - Swine
KW - Linear Models
KW - Diastole
KW - Dobutamine diagnostic use
KW - Echocardiography, Stress methods
KW - Fibrosis ultrasonography
KW - Systole
M3 - SCORING: Zeitschriftenaufsatz
VL - 27
SP - 552
EP - 562
JO - ECHOCARDIOGR-J CARD
JF - ECHOCARDIOGR-J CARD
SN - 0742-2822
IS - 5
M1 - 5
ER -
