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Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment

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Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment. / Georgouli, Mirella; Herraiz, Cecilia; Crosas-Molist, Eva; Fanshawe, Bruce; Maiques, Oscar; Perdrix, Anna; Pandya, Pahini; Rodriguez-Hernandez, Irene; Ilieva, Kristina M; Cantelli, Gaia; Karagiannis, Panagiotis; Mele, Silvia; Lam, Hoyin; Josephs, Debra H; Matias-Guiu, Xavier; Marti, Rosa M; Nestle, Frank O; Orgaz, Jose L; Malanchi, Ilaria; Fruhwirth, Gilbert O; Karagiannis, Sophia N; Sanz-Moreno, Victoria.

in: CELL, Jahrgang 176, Nr. 4, 07.02.2019, S. 757-774.e23.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Georgouli, M, Herraiz, C, Crosas-Molist, E, Fanshawe, B, Maiques, O, Perdrix, A, Pandya, P, Rodriguez-Hernandez, I, Ilieva, KM, Cantelli, G, Karagiannis, P, Mele, S, Lam, H, Josephs, DH, Matias-Guiu, X, Marti, RM, Nestle, FO, Orgaz, JL, Malanchi, I, Fruhwirth, GO, Karagiannis, SN & Sanz-Moreno, V 2019, 'Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment', CELL, Jg. 176, Nr. 4, S. 757-774.e23. https://doi.org/10.1016/j.cell.2018.12.038

APA

Georgouli, M., Herraiz, C., Crosas-Molist, E., Fanshawe, B., Maiques, O., Perdrix, A., Pandya, P., Rodriguez-Hernandez, I., Ilieva, K. M., Cantelli, G., Karagiannis, P., Mele, S., Lam, H., Josephs, D. H., Matias-Guiu, X., Marti, R. M., Nestle, F. O., Orgaz, J. L., Malanchi, I., ... Sanz-Moreno, V. (2019). Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment. CELL, 176(4), 757-774.e23. https://doi.org/10.1016/j.cell.2018.12.038

Vancouver

Georgouli M, Herraiz C, Crosas-Molist E, Fanshawe B, Maiques O, Perdrix A et al. Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment. CELL. 2019 Feb 7;176(4):757-774.e23. https://doi.org/10.1016/j.cell.2018.12.038

Bibtex

@article{7980c4a007164ac4a96b49caffcf3a05,
title = "Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment",
abstract = "ROCK-Myosin II drives fast rounded-amoeboid migration in cancer cells during metastatic dissemination. Analysis of human melanoma biopsies revealed that amoeboid melanoma cells with high Myosin II activity are predominant in the invasive fronts of primary tumors in proximity to CD206+CD163+ tumor-associated macrophages and vessels. Proteomic analysis shows that ROCK-Myosin II activity in amoeboid cancer cells controls an immunomodulatory secretome, enabling the recruitment of monocytes and their differentiation into tumor-promoting macrophages. Both amoeboid cancer cells and their associated macrophages support an abnormal vasculature, which ultimately facilitates tumor progression. Mechanistically, amoeboid cancer cells perpetuate their behavior via ROCK-Myosin II-driven IL-1α secretion and NF-κB activation. Using an array of tumor models, we show that high Myosin II activity in tumor cells reprograms the innate immune microenvironment to support tumor growth. We describe an unexpected role for Myosin II dynamics in cancer cells controlling myeloid function via secreted factors.",
keywords = "Journal Article",
author = "Mirella Georgouli and Cecilia Herraiz and Eva Crosas-Molist and Bruce Fanshawe and Oscar Maiques and Anna Perdrix and Pahini Pandya and Irene Rodriguez-Hernandez and Ilieva, {Kristina M} and Gaia Cantelli and Panagiotis Karagiannis and Silvia Mele and Hoyin Lam and Josephs, {Debra H} and Xavier Matias-Guiu and Marti, {Rosa M} and Nestle, {Frank O} and Orgaz, {Jose L} and Ilaria Malanchi and Fruhwirth, {Gilbert O} and Karagiannis, {Sophia N} and Victoria Sanz-Moreno",
note = "Copyright {\textcopyright} 2019 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2019",
month = feb,
day = "7",
doi = "10.1016/j.cell.2018.12.038",
language = "English",
volume = "176",
pages = "757--774.e23",
journal = "CELL",
issn = "0092-8674",
publisher = "Cell Press",
number = "4",

}

RIS

TY - JOUR

T1 - Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment

AU - Georgouli, Mirella

AU - Herraiz, Cecilia

AU - Crosas-Molist, Eva

AU - Fanshawe, Bruce

AU - Maiques, Oscar

AU - Perdrix, Anna

AU - Pandya, Pahini

AU - Rodriguez-Hernandez, Irene

AU - Ilieva, Kristina M

AU - Cantelli, Gaia

AU - Karagiannis, Panagiotis

AU - Mele, Silvia

AU - Lam, Hoyin

AU - Josephs, Debra H

AU - Matias-Guiu, Xavier

AU - Marti, Rosa M

AU - Nestle, Frank O

AU - Orgaz, Jose L

AU - Malanchi, Ilaria

AU - Fruhwirth, Gilbert O

AU - Karagiannis, Sophia N

AU - Sanz-Moreno, Victoria

N1 - Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2019/2/7

Y1 - 2019/2/7

N2 - ROCK-Myosin II drives fast rounded-amoeboid migration in cancer cells during metastatic dissemination. Analysis of human melanoma biopsies revealed that amoeboid melanoma cells with high Myosin II activity are predominant in the invasive fronts of primary tumors in proximity to CD206+CD163+ tumor-associated macrophages and vessels. Proteomic analysis shows that ROCK-Myosin II activity in amoeboid cancer cells controls an immunomodulatory secretome, enabling the recruitment of monocytes and their differentiation into tumor-promoting macrophages. Both amoeboid cancer cells and their associated macrophages support an abnormal vasculature, which ultimately facilitates tumor progression. Mechanistically, amoeboid cancer cells perpetuate their behavior via ROCK-Myosin II-driven IL-1α secretion and NF-κB activation. Using an array of tumor models, we show that high Myosin II activity in tumor cells reprograms the innate immune microenvironment to support tumor growth. We describe an unexpected role for Myosin II dynamics in cancer cells controlling myeloid function via secreted factors.

AB - ROCK-Myosin II drives fast rounded-amoeboid migration in cancer cells during metastatic dissemination. Analysis of human melanoma biopsies revealed that amoeboid melanoma cells with high Myosin II activity are predominant in the invasive fronts of primary tumors in proximity to CD206+CD163+ tumor-associated macrophages and vessels. Proteomic analysis shows that ROCK-Myosin II activity in amoeboid cancer cells controls an immunomodulatory secretome, enabling the recruitment of monocytes and their differentiation into tumor-promoting macrophages. Both amoeboid cancer cells and their associated macrophages support an abnormal vasculature, which ultimately facilitates tumor progression. Mechanistically, amoeboid cancer cells perpetuate their behavior via ROCK-Myosin II-driven IL-1α secretion and NF-κB activation. Using an array of tumor models, we show that high Myosin II activity in tumor cells reprograms the innate immune microenvironment to support tumor growth. We describe an unexpected role for Myosin II dynamics in cancer cells controlling myeloid function via secreted factors.

KW - Journal Article

U2 - 10.1016/j.cell.2018.12.038

DO - 10.1016/j.cell.2018.12.038

M3 - SCORING: Journal article

C2 - 30712866

VL - 176

SP - 757-774.e23

JO - CELL

JF - CELL

SN - 0092-8674

IS - 4

ER -