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Reelin controls the positioning of brainstem serotonergic raphe neurons

Standard

Reelin controls the positioning of brainstem serotonergic raphe neurons. / Shehabeldin, Reham; Lutz, David; Karsak, Meliha; Frotscher, Michael; Krieglstein, Kerstin; Sharaf, Ahmed.

in: PLOS ONE, Jahrgang 13, Nr. 7, 2018, S. e0200268.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Shehabeldin, R, Lutz, D, Karsak, M, Frotscher, M, Krieglstein, K & Sharaf, A 2018, 'Reelin controls the positioning of brainstem serotonergic raphe neurons', PLOS ONE, Jg. 13, Nr. 7, S. e0200268. https://doi.org/10.1371/journal.pone.0200268

APA

Shehabeldin, R., Lutz, D., Karsak, M., Frotscher, M., Krieglstein, K., & Sharaf, A. (2018). Reelin controls the positioning of brainstem serotonergic raphe neurons. PLOS ONE, 13(7), e0200268. https://doi.org/10.1371/journal.pone.0200268

Vancouver

Shehabeldin R, Lutz D, Karsak M, Frotscher M, Krieglstein K, Sharaf A. Reelin controls the positioning of brainstem serotonergic raphe neurons. PLOS ONE. 2018;13(7):e0200268. https://doi.org/10.1371/journal.pone.0200268

Bibtex

@article{c1a3854924ea43d6ac15f6c143cb9b18,
title = "Reelin controls the positioning of brainstem serotonergic raphe neurons",
abstract = "Serotonin (5-HT) acts as both a morphogenetic factor during early embryonic development and a neuromodulator of circuit plasticity in the mature brain. Dysregulation of serotonin signaling during critical periods is involved in developmental neurological disorders, such as schizophrenia and autism. In this study we focused on the consequences of defect reelin signaling for the development of the brainstem serotonergic raphe system. We observed that reelin signaling components are expressed by serotonergic neurons during the critical period of their lateral migration. Further, we found that reelin signaling is important for the normal migration of rostral, but not caudal hindbrain raphe nuclei and that reelin deficiency results in the malformation of the paramedian raphe nucleus and the lateral wings of the dorsal raphe nuclei. Additionally, we showed that serotonergic neurons projections to laminated brain structures were severely altered. With this study, we propose that the perturbation of canonical reelin signaling interferes with the orientation of tangentially, but not radially, migrating brainstem 5-HT neurons. Our results open the window for further studies on the interaction of reelin and serotonin and the pathogenesis of neurodevelopmental disorders.",
keywords = "Journal Article",
author = "Reham Shehabeldin and David Lutz and Meliha Karsak and Michael Frotscher and Kerstin Krieglstein and Ahmed Sharaf",
year = "2018",
doi = "10.1371/journal.pone.0200268",
language = "English",
volume = "13",
pages = "e0200268",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "7",

}

RIS

TY - JOUR

T1 - Reelin controls the positioning of brainstem serotonergic raphe neurons

AU - Shehabeldin, Reham

AU - Lutz, David

AU - Karsak, Meliha

AU - Frotscher, Michael

AU - Krieglstein, Kerstin

AU - Sharaf, Ahmed

PY - 2018

Y1 - 2018

N2 - Serotonin (5-HT) acts as both a morphogenetic factor during early embryonic development and a neuromodulator of circuit plasticity in the mature brain. Dysregulation of serotonin signaling during critical periods is involved in developmental neurological disorders, such as schizophrenia and autism. In this study we focused on the consequences of defect reelin signaling for the development of the brainstem serotonergic raphe system. We observed that reelin signaling components are expressed by serotonergic neurons during the critical period of their lateral migration. Further, we found that reelin signaling is important for the normal migration of rostral, but not caudal hindbrain raphe nuclei and that reelin deficiency results in the malformation of the paramedian raphe nucleus and the lateral wings of the dorsal raphe nuclei. Additionally, we showed that serotonergic neurons projections to laminated brain structures were severely altered. With this study, we propose that the perturbation of canonical reelin signaling interferes with the orientation of tangentially, but not radially, migrating brainstem 5-HT neurons. Our results open the window for further studies on the interaction of reelin and serotonin and the pathogenesis of neurodevelopmental disorders.

AB - Serotonin (5-HT) acts as both a morphogenetic factor during early embryonic development and a neuromodulator of circuit plasticity in the mature brain. Dysregulation of serotonin signaling during critical periods is involved in developmental neurological disorders, such as schizophrenia and autism. In this study we focused on the consequences of defect reelin signaling for the development of the brainstem serotonergic raphe system. We observed that reelin signaling components are expressed by serotonergic neurons during the critical period of their lateral migration. Further, we found that reelin signaling is important for the normal migration of rostral, but not caudal hindbrain raphe nuclei and that reelin deficiency results in the malformation of the paramedian raphe nucleus and the lateral wings of the dorsal raphe nuclei. Additionally, we showed that serotonergic neurons projections to laminated brain structures were severely altered. With this study, we propose that the perturbation of canonical reelin signaling interferes with the orientation of tangentially, but not radially, migrating brainstem 5-HT neurons. Our results open the window for further studies on the interaction of reelin and serotonin and the pathogenesis of neurodevelopmental disorders.

KW - Journal Article

U2 - 10.1371/journal.pone.0200268

DO - 10.1371/journal.pone.0200268

M3 - SCORING: Journal article

C2 - 30001399

VL - 13

SP - e0200268

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 7

ER -