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Reduction of IFN-I responses by plasmacytoid dendritic cells in a longitudinal trans men cohort

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Reduction of IFN-I responses by plasmacytoid dendritic cells in a longitudinal trans men cohort. / Grünhagel, Benjamin; Borggrewe, Malte; Hagen, Sven Hendrik; Ziegler, Susanne M; Henseling, Florian; Glau, Laura; Thiele, Rebecca-Jo; Pujantell, Maria; Sivayoganathan, Varshi; Padoan, Benedetta; Claussen, Janna M; Düsedau, Arne; Hennesen, Jana; Bunders, Madeleine J; Bonn, Stefan; Tolosa, Eva; Krebs, Christian F; Dorn, Christoph; Altfeld, Marcus.

in: ISCIENCE, Jahrgang 26, Nr. 11, 17.11.2023, S. 108209.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Grünhagel, B, Borggrewe, M, Hagen, SH, Ziegler, SM, Henseling, F, Glau, L, Thiele, R-J, Pujantell, M, Sivayoganathan, V, Padoan, B, Claussen, JM, Düsedau, A, Hennesen, J, Bunders, MJ, Bonn, S, Tolosa, E, Krebs, CF, Dorn, C & Altfeld, M 2023, 'Reduction of IFN-I responses by plasmacytoid dendritic cells in a longitudinal trans men cohort', ISCIENCE, Jg. 26, Nr. 11, S. 108209. https://doi.org/10.1016/j.isci.2023.108209

APA

Grünhagel, B., Borggrewe, M., Hagen, S. H., Ziegler, S. M., Henseling, F., Glau, L., Thiele, R-J., Pujantell, M., Sivayoganathan, V., Padoan, B., Claussen, J. M., Düsedau, A., Hennesen, J., Bunders, M. J., Bonn, S., Tolosa, E., Krebs, C. F., Dorn, C., & Altfeld, M. (2023). Reduction of IFN-I responses by plasmacytoid dendritic cells in a longitudinal trans men cohort. ISCIENCE, 26(11), 108209. https://doi.org/10.1016/j.isci.2023.108209

Vancouver

Grünhagel B, Borggrewe M, Hagen SH, Ziegler SM, Henseling F, Glau L et al. Reduction of IFN-I responses by plasmacytoid dendritic cells in a longitudinal trans men cohort. ISCIENCE. 2023 Nov 17;26(11):108209. https://doi.org/10.1016/j.isci.2023.108209

Bibtex

@article{2ab40c88faab4793b560b73279ddf9fa,
title = "Reduction of IFN-I responses by plasmacytoid dendritic cells in a longitudinal trans men cohort",
abstract = "Type I interferons (IFN-I) are important mediators of antiviral immunity and autoimmune diseases. Female plasmacytoid dendritic cells (pDCs) exert an elevated capacity to produce IFN-I upon toll-like receptor 7 (TLR7) activation compared to male pDCs, and both sex hormones and X-encoded genes have been implicated in these sex-specific differences. Using longitudinal samples from a trans men cohort receiving gender-affirming hormone therapy (GAHT), the impact of testosterone injections on TLR7-mediated IFN-I production by pDCs was assessed. Single-cell RNA analyses of pDCs showed downregulation of IFN-I-related gene expression signatures but also revealed transcriptional inter-donor heterogeneity. Longitudinal quantification showed continuous reduction of IFN-I protein production by pDCs and reduced expression of IFN-I-stimulated genes in peripheral blood mononuclear cells (PBMCs). These studies in trans men demonstrate that testosterone administration reduces IFN-I production by pDCs over time and provide insights into the immune-modulatory role of testosterone in sex-specific IFN-I-mediated immune responses.",
author = "Benjamin Gr{\"u}nhagel and Malte Borggrewe and Hagen, {Sven Hendrik} and Ziegler, {Susanne M} and Florian Henseling and Laura Glau and Rebecca-Jo Thiele and Maria Pujantell and Varshi Sivayoganathan and Benedetta Padoan and Claussen, {Janna M} and Arne D{\"u}sedau and Jana Hennesen and Bunders, {Madeleine J} and Stefan Bonn and Eva Tolosa and Krebs, {Christian F} and Christoph Dorn and Marcus Altfeld",
note = "{\textcopyright} 2023 The Author(s).",
year = "2023",
month = nov,
day = "17",
doi = "10.1016/j.isci.2023.108209",
language = "English",
volume = "26",
pages = "108209",
journal = "ISCIENCE",
issn = "2589-0042",
publisher = "Elsevier Inc.",
number = "11",

}

RIS

TY - JOUR

T1 - Reduction of IFN-I responses by plasmacytoid dendritic cells in a longitudinal trans men cohort

AU - Grünhagel, Benjamin

AU - Borggrewe, Malte

AU - Hagen, Sven Hendrik

AU - Ziegler, Susanne M

AU - Henseling, Florian

AU - Glau, Laura

AU - Thiele, Rebecca-Jo

AU - Pujantell, Maria

AU - Sivayoganathan, Varshi

AU - Padoan, Benedetta

AU - Claussen, Janna M

AU - Düsedau, Arne

AU - Hennesen, Jana

AU - Bunders, Madeleine J

AU - Bonn, Stefan

AU - Tolosa, Eva

AU - Krebs, Christian F

AU - Dorn, Christoph

AU - Altfeld, Marcus

N1 - © 2023 The Author(s).

PY - 2023/11/17

Y1 - 2023/11/17

N2 - Type I interferons (IFN-I) are important mediators of antiviral immunity and autoimmune diseases. Female plasmacytoid dendritic cells (pDCs) exert an elevated capacity to produce IFN-I upon toll-like receptor 7 (TLR7) activation compared to male pDCs, and both sex hormones and X-encoded genes have been implicated in these sex-specific differences. Using longitudinal samples from a trans men cohort receiving gender-affirming hormone therapy (GAHT), the impact of testosterone injections on TLR7-mediated IFN-I production by pDCs was assessed. Single-cell RNA analyses of pDCs showed downregulation of IFN-I-related gene expression signatures but also revealed transcriptional inter-donor heterogeneity. Longitudinal quantification showed continuous reduction of IFN-I protein production by pDCs and reduced expression of IFN-I-stimulated genes in peripheral blood mononuclear cells (PBMCs). These studies in trans men demonstrate that testosterone administration reduces IFN-I production by pDCs over time and provide insights into the immune-modulatory role of testosterone in sex-specific IFN-I-mediated immune responses.

AB - Type I interferons (IFN-I) are important mediators of antiviral immunity and autoimmune diseases. Female plasmacytoid dendritic cells (pDCs) exert an elevated capacity to produce IFN-I upon toll-like receptor 7 (TLR7) activation compared to male pDCs, and both sex hormones and X-encoded genes have been implicated in these sex-specific differences. Using longitudinal samples from a trans men cohort receiving gender-affirming hormone therapy (GAHT), the impact of testosterone injections on TLR7-mediated IFN-I production by pDCs was assessed. Single-cell RNA analyses of pDCs showed downregulation of IFN-I-related gene expression signatures but also revealed transcriptional inter-donor heterogeneity. Longitudinal quantification showed continuous reduction of IFN-I protein production by pDCs and reduced expression of IFN-I-stimulated genes in peripheral blood mononuclear cells (PBMCs). These studies in trans men demonstrate that testosterone administration reduces IFN-I production by pDCs over time and provide insights into the immune-modulatory role of testosterone in sex-specific IFN-I-mediated immune responses.

U2 - 10.1016/j.isci.2023.108209

DO - 10.1016/j.isci.2023.108209

M3 - SCORING: Journal article

C2 - 37953956

VL - 26

SP - 108209

JO - ISCIENCE

JF - ISCIENCE

SN - 2589-0042

IS - 11

ER -