Reduced phospholipid breakdown in Alzheimer's brains: a 31P spectroscopy study.
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Reduced phospholipid breakdown in Alzheimer's brains: a 31P spectroscopy study. / Forlenza, Orestes V; Wacker, Priscilla; Nunes, Paula V; Yacubian, Juliana; Castro, Claudio C; Otaduy, Maria C G; Gattaz, Wagner F.
in: PSYCHOPHARMACOLOGY, Jahrgang 180, Nr. 2, 2, 2005, S. 359-365.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Reduced phospholipid breakdown in Alzheimer's brains: a 31P spectroscopy study.
AU - Forlenza, Orestes V
AU - Wacker, Priscilla
AU - Nunes, Paula V
AU - Yacubian, Juliana
AU - Castro, Claudio C
AU - Otaduy, Maria C G
AU - Gattaz, Wagner F
PY - 2005
Y1 - 2005
N2 - BACKGROUND: Abnormalities of membrane phospholipid metabolism have been described in Alzheimer's disease (AD). We investigated, with the aid of (31)P magnetic resonance spectroscopy, the in vivo intracerebral availability of phosphomonoesters (PME) and phosphodiesters (PDE) in patients with AD. METHODS: Eighteen outpatients with mild or moderate probable AD and 16 nondemented elderly volunteers were assessed with the Cambridge Examination for Mental Disorders of the Elderly (CAMDEX) and its cognitive subscale of the CAMDEX schedule (CAMCOG). Scans were performed on a 1.5 T magnetic resonance imager addressing a 40-cm(3) voxel in the left prefrontal cortex. Main outcome measures were mean relative peak areas of PME and PDE, which provide an estimate of membrane phospholipid metabolism. RESULTS: PME resonance and the PME/PDE ratio were increased in AD patients as compared to controls (p
AB - BACKGROUND: Abnormalities of membrane phospholipid metabolism have been described in Alzheimer's disease (AD). We investigated, with the aid of (31)P magnetic resonance spectroscopy, the in vivo intracerebral availability of phosphomonoesters (PME) and phosphodiesters (PDE) in patients with AD. METHODS: Eighteen outpatients with mild or moderate probable AD and 16 nondemented elderly volunteers were assessed with the Cambridge Examination for Mental Disorders of the Elderly (CAMDEX) and its cognitive subscale of the CAMDEX schedule (CAMCOG). Scans were performed on a 1.5 T magnetic resonance imager addressing a 40-cm(3) voxel in the left prefrontal cortex. Main outcome measures were mean relative peak areas of PME and PDE, which provide an estimate of membrane phospholipid metabolism. RESULTS: PME resonance and the PME/PDE ratio were increased in AD patients as compared to controls (p
M3 - SCORING: Zeitschriftenaufsatz
VL - 180
SP - 359
EP - 365
JO - PSYCHOPHARMACOLOGY
JF - PSYCHOPHARMACOLOGY
SN - 0033-3158
IS - 2
M1 - 2
ER -
