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Reduced mitochondrial respiration in T cells of patients with major depressive disorder

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Reduced mitochondrial respiration in T cells of patients with major depressive disorder. / Gamradt, Stefanie; Hasselmann, Helge; Taenzer, Aline; Brasanac, Jelena; Stiglbauer, Victoria; Sattler, Arne; Sajitz-Hermstein, Max; Kierszniowska, Sylwia; Ramien, Caren; Nowacki, Jan; Mascarell-Maricic, Lea; Wingenfeld, Katja; Piber, Dominique; Ströhle, Andreas; Kotsch, Katja; Paul, Friedemann; Otte, Christian; Gold, Stefan M.

in: ISCIENCE, Jahrgang 24, Nr. 11, 103312, 19.11.2021.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Gamradt, S, Hasselmann, H, Taenzer, A, Brasanac, J, Stiglbauer, V, Sattler, A, Sajitz-Hermstein, M, Kierszniowska, S, Ramien, C, Nowacki, J, Mascarell-Maricic, L, Wingenfeld, K, Piber, D, Ströhle, A, Kotsch, K, Paul, F, Otte, C & Gold, SM 2021, 'Reduced mitochondrial respiration in T cells of patients with major depressive disorder', ISCIENCE, Jg. 24, Nr. 11, 103312. https://doi.org/10.1016/j.isci.2021.103312

APA

Gamradt, S., Hasselmann, H., Taenzer, A., Brasanac, J., Stiglbauer, V., Sattler, A., Sajitz-Hermstein, M., Kierszniowska, S., Ramien, C., Nowacki, J., Mascarell-Maricic, L., Wingenfeld, K., Piber, D., Ströhle, A., Kotsch, K., Paul, F., Otte, C., & Gold, S. M. (2021). Reduced mitochondrial respiration in T cells of patients with major depressive disorder. ISCIENCE, 24(11), [103312]. https://doi.org/10.1016/j.isci.2021.103312

Vancouver

Gamradt S, Hasselmann H, Taenzer A, Brasanac J, Stiglbauer V, Sattler A et al. Reduced mitochondrial respiration in T cells of patients with major depressive disorder. ISCIENCE. 2021 Nov 19;24(11). 103312. https://doi.org/10.1016/j.isci.2021.103312

Bibtex

@article{ae01677110084b92897a345fc67128df,
title = "Reduced mitochondrial respiration in T cells of patients with major depressive disorder",
abstract = "Converging evidence indicates that major depressive disorder (MDD) and metabolic disorders might be mediated by shared (patho)biological pathways. However, the converging cellular and molecular signatures remain unknown. Here, we investigated metabolic dysfunction on a systemic, cellular, and molecular level in unmedicated patients with MDD compared with matched healthy controls (HC). Despite comparable BMI scores and absence of cardiometabolic disease, patients with MDD presented with significant dyslipidemia. On a cellular level, T cells obtained from patients with MDD exhibited reduced respiratory and glycolytic capacity. Gene expression analysis revealed increased carnitine palmitoyltransferase IA (CPT1a) levels in T cells, the rate-limiting enzyme for mitochondrial long-chain fatty acid oxidation. Together, our results indicate metabolic dysfunction in unmedicated, non-overweight patients with MDD on a systemic, cellular, and molecular level. This evidence for reduced mitochondrial respiration in T cells of patients with MDD provides translation of previous animal studies regarding a putative role of altered immunometabolism in depression pathobiology.",
author = "Stefanie Gamradt and Helge Hasselmann and Aline Taenzer and Jelena Brasanac and Victoria Stiglbauer and Arne Sattler and Max Sajitz-Hermstein and Sylwia Kierszniowska and Caren Ramien and Jan Nowacki and Lea Mascarell-Maricic and Katja Wingenfeld and Dominique Piber and Andreas Str{\"o}hle and Katja Kotsch and Friedemann Paul and Christian Otte and Gold, {Stefan M}",
note = "{\textcopyright} 2021 The Authors.",
year = "2021",
month = nov,
day = "19",
doi = "10.1016/j.isci.2021.103312",
language = "English",
volume = "24",
journal = "ISCIENCE",
issn = "2589-0042",
publisher = "Elsevier Inc.",
number = "11",

}

RIS

TY - JOUR

T1 - Reduced mitochondrial respiration in T cells of patients with major depressive disorder

AU - Gamradt, Stefanie

AU - Hasselmann, Helge

AU - Taenzer, Aline

AU - Brasanac, Jelena

AU - Stiglbauer, Victoria

AU - Sattler, Arne

AU - Sajitz-Hermstein, Max

AU - Kierszniowska, Sylwia

AU - Ramien, Caren

AU - Nowacki, Jan

AU - Mascarell-Maricic, Lea

AU - Wingenfeld, Katja

AU - Piber, Dominique

AU - Ströhle, Andreas

AU - Kotsch, Katja

AU - Paul, Friedemann

AU - Otte, Christian

AU - Gold, Stefan M

N1 - © 2021 The Authors.

PY - 2021/11/19

Y1 - 2021/11/19

N2 - Converging evidence indicates that major depressive disorder (MDD) and metabolic disorders might be mediated by shared (patho)biological pathways. However, the converging cellular and molecular signatures remain unknown. Here, we investigated metabolic dysfunction on a systemic, cellular, and molecular level in unmedicated patients with MDD compared with matched healthy controls (HC). Despite comparable BMI scores and absence of cardiometabolic disease, patients with MDD presented with significant dyslipidemia. On a cellular level, T cells obtained from patients with MDD exhibited reduced respiratory and glycolytic capacity. Gene expression analysis revealed increased carnitine palmitoyltransferase IA (CPT1a) levels in T cells, the rate-limiting enzyme for mitochondrial long-chain fatty acid oxidation. Together, our results indicate metabolic dysfunction in unmedicated, non-overweight patients with MDD on a systemic, cellular, and molecular level. This evidence for reduced mitochondrial respiration in T cells of patients with MDD provides translation of previous animal studies regarding a putative role of altered immunometabolism in depression pathobiology.

AB - Converging evidence indicates that major depressive disorder (MDD) and metabolic disorders might be mediated by shared (patho)biological pathways. However, the converging cellular and molecular signatures remain unknown. Here, we investigated metabolic dysfunction on a systemic, cellular, and molecular level in unmedicated patients with MDD compared with matched healthy controls (HC). Despite comparable BMI scores and absence of cardiometabolic disease, patients with MDD presented with significant dyslipidemia. On a cellular level, T cells obtained from patients with MDD exhibited reduced respiratory and glycolytic capacity. Gene expression analysis revealed increased carnitine palmitoyltransferase IA (CPT1a) levels in T cells, the rate-limiting enzyme for mitochondrial long-chain fatty acid oxidation. Together, our results indicate metabolic dysfunction in unmedicated, non-overweight patients with MDD on a systemic, cellular, and molecular level. This evidence for reduced mitochondrial respiration in T cells of patients with MDD provides translation of previous animal studies regarding a putative role of altered immunometabolism in depression pathobiology.

U2 - 10.1016/j.isci.2021.103312

DO - 10.1016/j.isci.2021.103312

M3 - SCORING: Journal article

C2 - 34765928

VL - 24

JO - ISCIENCE

JF - ISCIENCE

SN - 2589-0042

IS - 11

M1 - 103312

ER -