Reduced early auditory evoked gamma-band response in patients with schizophrenia.
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Reduced early auditory evoked gamma-band response in patients with schizophrenia. / Leicht, Gregor; Kirsch, Valerie; Giegling, Ina; Karch, Susanne; Hantschk, Irmgard; Möller, Hans-Jürgen; Pogarell, Oliver; Hegerl, Ulrich; Rujescu, Dan; Mulert, Christoph.
in: BIOL PSYCHIAT, Jahrgang 67, Nr. 3, 3, 2010, S. 224-231.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Reduced early auditory evoked gamma-band response in patients with schizophrenia.
AU - Leicht, Gregor
AU - Kirsch, Valerie
AU - Giegling, Ina
AU - Karch, Susanne
AU - Hantschk, Irmgard
AU - Möller, Hans-Jürgen
AU - Pogarell, Oliver
AU - Hegerl, Ulrich
AU - Rujescu, Dan
AU - Mulert, Christoph
PY - 2010
Y1 - 2010
N2 - There is growing evidence for abnormalities of certain gamma-aminobutyric acid (GABA)-ergic interneurons and their interaction with glutamatergic pyramidal cells in schizophrenia. These interneurons are critically involved in generating neural activity in the gamma-band (30-100 Hz) of the electroencephalogram. One example of such gamma oscillations is the early auditory evoked gamma-band response (GBR). Although auditory processing is obviously disturbed in schizophrenia, there is no direct evidence providing a reduced early auditory evoked GBR so far. We addressed two questions: 1) Is the early auditory evoked GBR decreased regarding power and phase-locking in schizophrenic patients?; and 2) Is this possible decrease a result of reduced activity in the auditory cortex and/or the anterior cingulate cortex (ACC), which were identified as sources of the GBR previously?
AB - There is growing evidence for abnormalities of certain gamma-aminobutyric acid (GABA)-ergic interneurons and their interaction with glutamatergic pyramidal cells in schizophrenia. These interneurons are critically involved in generating neural activity in the gamma-band (30-100 Hz) of the electroencephalogram. One example of such gamma oscillations is the early auditory evoked gamma-band response (GBR). Although auditory processing is obviously disturbed in schizophrenia, there is no direct evidence providing a reduced early auditory evoked GBR so far. We addressed two questions: 1) Is the early auditory evoked GBR decreased regarding power and phase-locking in schizophrenic patients?; and 2) Is this possible decrease a result of reduced activity in the auditory cortex and/or the anterior cingulate cortex (ACC), which were identified as sources of the GBR previously?
M3 - SCORING: Zeitschriftenaufsatz
VL - 67
SP - 224
EP - 231
JO - BIOL PSYCHIAT
JF - BIOL PSYCHIAT
SN - 0006-3223
IS - 3
M1 - 3
ER -