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Redistribution, Homing and Organ-Invasion of Neoplastic Stem Cells in Myeloid Neoplasms

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Redistribution, Homing and Organ-Invasion of Neoplastic Stem Cells in Myeloid Neoplasms. / Valent, Peter; Sadovnik, Irina; Eisenwort, Gregor; Herrmann, Harald; Bauer, Karin; Mueller, Niklas; Sperr, Wolfgang R; Wicklein, Daniel; Schumacher, Udo.

in: SEMIN CANCER BIOL, Jahrgang 60, 02.2020, S. 191-201.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Valent, P, Sadovnik, I, Eisenwort, G, Herrmann, H, Bauer, K, Mueller, N, Sperr, WR, Wicklein, D & Schumacher, U 2020, 'Redistribution, Homing and Organ-Invasion of Neoplastic Stem Cells in Myeloid Neoplasms', SEMIN CANCER BIOL, Jg. 60, S. 191-201. https://doi.org/10.1016/j.semcancer.2019.07.025

APA

Valent, P., Sadovnik, I., Eisenwort, G., Herrmann, H., Bauer, K., Mueller, N., Sperr, W. R., Wicklein, D., & Schumacher, U. (2020). Redistribution, Homing and Organ-Invasion of Neoplastic Stem Cells in Myeloid Neoplasms. SEMIN CANCER BIOL, 60, 191-201. https://doi.org/10.1016/j.semcancer.2019.07.025

Vancouver

Valent P, Sadovnik I, Eisenwort G, Herrmann H, Bauer K, Mueller N et al. Redistribution, Homing and Organ-Invasion of Neoplastic Stem Cells in Myeloid Neoplasms. SEMIN CANCER BIOL. 2020 Feb;60:191-201. https://doi.org/10.1016/j.semcancer.2019.07.025

Bibtex

@article{afda563e9d6d40ae926511915814e3b1,
title = "Redistribution, Homing and Organ-Invasion of Neoplastic Stem Cells in Myeloid Neoplasms",
abstract = "The development of a myeloid neoplasm is a step-wise process that originates from leukemic stem cells (LSC) and includes pre-leukemic stages, overt leukemia and a drug-resistant terminal phase. Organ-invasion may occur in any stage, but is usually associated with advanced disease and a poor prognosis. Sometimes, extra-medullary organ invasion shows a metastasis-like or even sarcoma-like destructive growth of neoplastic cells in local tissue sites. Examples are myeloid sarcoma, mast cell sarcoma and localized blast phase of chronic myeloid leukemia. So far, little is known about mechanisms underlying re-distribution and extramedullary dissemination of LSC in myeloid neoplasms. In this article, we discuss mechanisms through which LSC can mobilize out of the bone marrow niche, can transmigrate from the blood stream into extramedullary organs, can invade local tissue sites and can potentially create or support the formation of local stem cell niches. In addition, we discuss strategies to interfere with LSC expansion and organ invasion by targeted drug therapies.",
keywords = "Animals, Biomarkers, Bone Marrow/pathology, Cell Communication, Cell Movement, Humans, Immunophenotyping, Leukemia, Myeloid/etiology, Neoplasm Staging, Neoplastic Stem Cells/metabolism, Phenotype, Recurrence, Transendothelial and Transepithelial Migration/genetics, Tumor Microenvironment/genetics",
author = "Peter Valent and Irina Sadovnik and Gregor Eisenwort and Harald Herrmann and Karin Bauer and Niklas Mueller and Sperr, {Wolfgang R} and Daniel Wicklein and Udo Schumacher",
note = "Copyright {\textcopyright} 2019 Elsevier Ltd. All rights reserved.",
year = "2020",
month = feb,
doi = "10.1016/j.semcancer.2019.07.025",
language = "English",
volume = "60",
pages = "191--201",
journal = "SEMIN CANCER BIOL",
issn = "1044-579X",
publisher = "Academic Press Inc.",

}

RIS

TY - JOUR

T1 - Redistribution, Homing and Organ-Invasion of Neoplastic Stem Cells in Myeloid Neoplasms

AU - Valent, Peter

AU - Sadovnik, Irina

AU - Eisenwort, Gregor

AU - Herrmann, Harald

AU - Bauer, Karin

AU - Mueller, Niklas

AU - Sperr, Wolfgang R

AU - Wicklein, Daniel

AU - Schumacher, Udo

N1 - Copyright © 2019 Elsevier Ltd. All rights reserved.

PY - 2020/2

Y1 - 2020/2

N2 - The development of a myeloid neoplasm is a step-wise process that originates from leukemic stem cells (LSC) and includes pre-leukemic stages, overt leukemia and a drug-resistant terminal phase. Organ-invasion may occur in any stage, but is usually associated with advanced disease and a poor prognosis. Sometimes, extra-medullary organ invasion shows a metastasis-like or even sarcoma-like destructive growth of neoplastic cells in local tissue sites. Examples are myeloid sarcoma, mast cell sarcoma and localized blast phase of chronic myeloid leukemia. So far, little is known about mechanisms underlying re-distribution and extramedullary dissemination of LSC in myeloid neoplasms. In this article, we discuss mechanisms through which LSC can mobilize out of the bone marrow niche, can transmigrate from the blood stream into extramedullary organs, can invade local tissue sites and can potentially create or support the formation of local stem cell niches. In addition, we discuss strategies to interfere with LSC expansion and organ invasion by targeted drug therapies.

AB - The development of a myeloid neoplasm is a step-wise process that originates from leukemic stem cells (LSC) and includes pre-leukemic stages, overt leukemia and a drug-resistant terminal phase. Organ-invasion may occur in any stage, but is usually associated with advanced disease and a poor prognosis. Sometimes, extra-medullary organ invasion shows a metastasis-like or even sarcoma-like destructive growth of neoplastic cells in local tissue sites. Examples are myeloid sarcoma, mast cell sarcoma and localized blast phase of chronic myeloid leukemia. So far, little is known about mechanisms underlying re-distribution and extramedullary dissemination of LSC in myeloid neoplasms. In this article, we discuss mechanisms through which LSC can mobilize out of the bone marrow niche, can transmigrate from the blood stream into extramedullary organs, can invade local tissue sites and can potentially create or support the formation of local stem cell niches. In addition, we discuss strategies to interfere with LSC expansion and organ invasion by targeted drug therapies.

KW - Animals

KW - Biomarkers

KW - Bone Marrow/pathology

KW - Cell Communication

KW - Cell Movement

KW - Humans

KW - Immunophenotyping

KW - Leukemia, Myeloid/etiology

KW - Neoplasm Staging

KW - Neoplastic Stem Cells/metabolism

KW - Phenotype

KW - Recurrence

KW - Transendothelial and Transepithelial Migration/genetics

KW - Tumor Microenvironment/genetics

U2 - 10.1016/j.semcancer.2019.07.025

DO - 10.1016/j.semcancer.2019.07.025

M3 - SCORING: Review article

C2 - 31408723

VL - 60

SP - 191

EP - 201

JO - SEMIN CANCER BIOL

JF - SEMIN CANCER BIOL

SN - 1044-579X

ER -