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Recurrent deep-vein thrombosis based on homozygous factor V Leiden mutation acquired after liver transplantation.

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Recurrent deep-vein thrombosis based on homozygous factor V Leiden mutation acquired after liver transplantation. / Willems, Marc; Sterneck, Martina; Langer, Florian; Jung, Roman; Haddad, Munif; Hagel, Christian; Kuetemeier, Robert; Eifrig, Barbara; Broering, Dieter; Fischer, Lutz; Rogiers, Xavier.

in: LIVER TRANSPLANT, Jahrgang 9, Nr. 8, 8, 2003, S. 870-873.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Willems, M, Sterneck, M, Langer, F, Jung, R, Haddad, M, Hagel, C, Kuetemeier, R, Eifrig, B, Broering, D, Fischer, L & Rogiers, X 2003, 'Recurrent deep-vein thrombosis based on homozygous factor V Leiden mutation acquired after liver transplantation.', LIVER TRANSPLANT, Jg. 9, Nr. 8, 8, S. 870-873. <http://www.ncbi.nlm.nih.gov/pubmed/12884202?dopt=Citation>

APA

Willems, M., Sterneck, M., Langer, F., Jung, R., Haddad, M., Hagel, C., Kuetemeier, R., Eifrig, B., Broering, D., Fischer, L., & Rogiers, X. (2003). Recurrent deep-vein thrombosis based on homozygous factor V Leiden mutation acquired after liver transplantation. LIVER TRANSPLANT, 9(8), 870-873. [8]. http://www.ncbi.nlm.nih.gov/pubmed/12884202?dopt=Citation

Vancouver

Willems M, Sterneck M, Langer F, Jung R, Haddad M, Hagel C et al. Recurrent deep-vein thrombosis based on homozygous factor V Leiden mutation acquired after liver transplantation. LIVER TRANSPLANT. 2003;9(8):870-873. 8.

Bibtex

@article{9cc23d401be7486c8a2229afa158e503,
title = "Recurrent deep-vein thrombosis based on homozygous factor V Leiden mutation acquired after liver transplantation.",
abstract = "Several genetic liver diseases can be treated by liver transplantation (LT). However, some genetic defects also may be acquired by this procedure. We describe a patient who developed recurrent deep-vein thromboses after LT for hepatitis C virus-associated hepatocellular carcinoma on the basis of a homozygous Leiden mutation of the factor V gene in the donor liver. Liver donors with a history of venous thrombosis should be screened for the presence of activated protein C (APC) resistance. In addition, we recommend looking for APC resistance in liver recipients who develop venous thromboembolic disease in the post-LT course. Molecular analysis of donor tissue may be necessary to make a definite diagnosis of factor V Leiden mutation in these patients. As a consequence, intensified postoperative thromboprophylaxis or lifelong anticoagulant therapy may be necessary if this thrombophilic gene defect is detected.",
author = "Marc Willems and Martina Sterneck and Florian Langer and Roman Jung and Munif Haddad and Christian Hagel and Robert Kuetemeier and Barbara Eifrig and Dieter Broering and Lutz Fischer and Xavier Rogiers",
year = "2003",
language = "Deutsch",
volume = "9",
pages = "870--873",
journal = "LIVER TRANSPLANT",
issn = "1527-6465",
publisher = "John Wiley and Sons Ltd",
number = "8",

}

RIS

TY - JOUR

T1 - Recurrent deep-vein thrombosis based on homozygous factor V Leiden mutation acquired after liver transplantation.

AU - Willems, Marc

AU - Sterneck, Martina

AU - Langer, Florian

AU - Jung, Roman

AU - Haddad, Munif

AU - Hagel, Christian

AU - Kuetemeier, Robert

AU - Eifrig, Barbara

AU - Broering, Dieter

AU - Fischer, Lutz

AU - Rogiers, Xavier

PY - 2003

Y1 - 2003

N2 - Several genetic liver diseases can be treated by liver transplantation (LT). However, some genetic defects also may be acquired by this procedure. We describe a patient who developed recurrent deep-vein thromboses after LT for hepatitis C virus-associated hepatocellular carcinoma on the basis of a homozygous Leiden mutation of the factor V gene in the donor liver. Liver donors with a history of venous thrombosis should be screened for the presence of activated protein C (APC) resistance. In addition, we recommend looking for APC resistance in liver recipients who develop venous thromboembolic disease in the post-LT course. Molecular analysis of donor tissue may be necessary to make a definite diagnosis of factor V Leiden mutation in these patients. As a consequence, intensified postoperative thromboprophylaxis or lifelong anticoagulant therapy may be necessary if this thrombophilic gene defect is detected.

AB - Several genetic liver diseases can be treated by liver transplantation (LT). However, some genetic defects also may be acquired by this procedure. We describe a patient who developed recurrent deep-vein thromboses after LT for hepatitis C virus-associated hepatocellular carcinoma on the basis of a homozygous Leiden mutation of the factor V gene in the donor liver. Liver donors with a history of venous thrombosis should be screened for the presence of activated protein C (APC) resistance. In addition, we recommend looking for APC resistance in liver recipients who develop venous thromboembolic disease in the post-LT course. Molecular analysis of donor tissue may be necessary to make a definite diagnosis of factor V Leiden mutation in these patients. As a consequence, intensified postoperative thromboprophylaxis or lifelong anticoagulant therapy may be necessary if this thrombophilic gene defect is detected.

M3 - SCORING: Zeitschriftenaufsatz

VL - 9

SP - 870

EP - 873

JO - LIVER TRANSPLANT

JF - LIVER TRANSPLANT

SN - 1527-6465

IS - 8

M1 - 8

ER -