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Recurrence of Ewing sarcoma: Is detection by imaging follow-up protocol associated with survival advantage?

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Recurrence of Ewing sarcoma: Is detection by imaging follow-up protocol associated with survival advantage? / Heinemann, Melina; Ranft, Andreas; Langer, Thorsten; Jürgens, Herbert; Kreyer, Justus; Vieth, Volker; Schäfers, Michael; Weckesser, Matthias; Simon, Thorsten; Hassenpflug, Wolf; Corbacioglu, Selim; Bielack, Stefan; Mayer-Steinacker, Regina; Kühne, Thomas; van den Berg, Henk; Gelderblom, Hans; Bauer, Sebastian; Stegger, Lars; Dirksen, Uta.

in: PEDIATR BLOOD CANCER, Jahrgang 65, Nr. 7, 07.2018, S. e27011.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Heinemann, M, Ranft, A, Langer, T, Jürgens, H, Kreyer, J, Vieth, V, Schäfers, M, Weckesser, M, Simon, T, Hassenpflug, W, Corbacioglu, S, Bielack, S, Mayer-Steinacker, R, Kühne, T, van den Berg, H, Gelderblom, H, Bauer, S, Stegger, L & Dirksen, U 2018, 'Recurrence of Ewing sarcoma: Is detection by imaging follow-up protocol associated with survival advantage?', PEDIATR BLOOD CANCER, Jg. 65, Nr. 7, S. e27011. https://doi.org/10.1002/pbc.27011

APA

Heinemann, M., Ranft, A., Langer, T., Jürgens, H., Kreyer, J., Vieth, V., Schäfers, M., Weckesser, M., Simon, T., Hassenpflug, W., Corbacioglu, S., Bielack, S., Mayer-Steinacker, R., Kühne, T., van den Berg, H., Gelderblom, H., Bauer, S., Stegger, L., & Dirksen, U. (2018). Recurrence of Ewing sarcoma: Is detection by imaging follow-up protocol associated with survival advantage? PEDIATR BLOOD CANCER, 65(7), e27011. https://doi.org/10.1002/pbc.27011

Vancouver

Heinemann M, Ranft A, Langer T, Jürgens H, Kreyer J, Vieth V et al. Recurrence of Ewing sarcoma: Is detection by imaging follow-up protocol associated with survival advantage? PEDIATR BLOOD CANCER. 2018 Jul;65(7):e27011. https://doi.org/10.1002/pbc.27011

Bibtex

@article{371599a0aab24e1d8ac3f5165b42e8e9,
title = "Recurrence of Ewing sarcoma: Is detection by imaging follow-up protocol associated with survival advantage?",
abstract = "BACKGROUND: The Cooperative Ewing Sarcoma Study and the Late Effects Surveillance System of the Society for Paediatric Oncology and Haematology recommend a structured follow-up imaging protocol (FUIP) for patients with Ewing sarcoma (EwS) with decreasing frequency of imaging over the first 5 years. The present study aims to assess the effectiveness of the FUIP for EwS patients regarding survival after relapse.PATIENTS AND METHODS: A retrospective multicenter analysis on 160 eligible patients with EwS recurrence was performed. Potential survival differences following recurrence diagnosis between patients with protocol-detected and symptomatic relapse were investigated using the Kaplan-Meier method. Additional subgroup analyses were performed on the relapse type. Overall survival (OS) was calculated from diagnosis of relapse to last follow-up or death.RESULTS: In the multicenter analysis, recurrence was detected by FUIP in 77 of 160 patients (48%) and due to symptoms in 83 patients (52%). Regarding the entire study population, OS was significantly superior in patients with protocol-detected relapse compared to patients with symptomatic relapse (median, 2.4 vs. 1.2 years; P < 0.001). In the subgroup analyses, patients whose lung recurrences were detected by the FUIP experienced longer survival after recurrence than those whose recurrences were detected symptomatically (P = 0.023). In the 83 symptomatic patients, pain was the most prevalent symptom of relapse (72%).CONCLUSION: FUIP may benefit survival in EwS relapse, especially in lung recurrence. Pain was the leading symptom of relapse.",
keywords = "Journal Article",
author = "Melina Heinemann and Andreas Ranft and Thorsten Langer and Herbert J{\"u}rgens and Justus Kreyer and Volker Vieth and Michael Sch{\"a}fers and Matthias Weckesser and Thorsten Simon and Wolf Hassenpflug and Selim Corbacioglu and Stefan Bielack and Regina Mayer-Steinacker and Thomas K{\"u}hne and {van den Berg}, Henk and Hans Gelderblom and Sebastian Bauer and Lars Stegger and Uta Dirksen",
note = "{\textcopyright} 2018 Wiley Periodicals, Inc.",
year = "2018",
month = jul,
doi = "10.1002/pbc.27011",
language = "English",
volume = "65",
pages = "e27011",
journal = "PEDIATR BLOOD CANCER",
issn = "1545-5009",
publisher = "Wiley-Liss Inc.",
number = "7",

}

RIS

TY - JOUR

T1 - Recurrence of Ewing sarcoma: Is detection by imaging follow-up protocol associated with survival advantage?

AU - Heinemann, Melina

AU - Ranft, Andreas

AU - Langer, Thorsten

AU - Jürgens, Herbert

AU - Kreyer, Justus

AU - Vieth, Volker

AU - Schäfers, Michael

AU - Weckesser, Matthias

AU - Simon, Thorsten

AU - Hassenpflug, Wolf

AU - Corbacioglu, Selim

AU - Bielack, Stefan

AU - Mayer-Steinacker, Regina

AU - Kühne, Thomas

AU - van den Berg, Henk

AU - Gelderblom, Hans

AU - Bauer, Sebastian

AU - Stegger, Lars

AU - Dirksen, Uta

N1 - © 2018 Wiley Periodicals, Inc.

PY - 2018/7

Y1 - 2018/7

N2 - BACKGROUND: The Cooperative Ewing Sarcoma Study and the Late Effects Surveillance System of the Society for Paediatric Oncology and Haematology recommend a structured follow-up imaging protocol (FUIP) for patients with Ewing sarcoma (EwS) with decreasing frequency of imaging over the first 5 years. The present study aims to assess the effectiveness of the FUIP for EwS patients regarding survival after relapse.PATIENTS AND METHODS: A retrospective multicenter analysis on 160 eligible patients with EwS recurrence was performed. Potential survival differences following recurrence diagnosis between patients with protocol-detected and symptomatic relapse were investigated using the Kaplan-Meier method. Additional subgroup analyses were performed on the relapse type. Overall survival (OS) was calculated from diagnosis of relapse to last follow-up or death.RESULTS: In the multicenter analysis, recurrence was detected by FUIP in 77 of 160 patients (48%) and due to symptoms in 83 patients (52%). Regarding the entire study population, OS was significantly superior in patients with protocol-detected relapse compared to patients with symptomatic relapse (median, 2.4 vs. 1.2 years; P < 0.001). In the subgroup analyses, patients whose lung recurrences were detected by the FUIP experienced longer survival after recurrence than those whose recurrences were detected symptomatically (P = 0.023). In the 83 symptomatic patients, pain was the most prevalent symptom of relapse (72%).CONCLUSION: FUIP may benefit survival in EwS relapse, especially in lung recurrence. Pain was the leading symptom of relapse.

AB - BACKGROUND: The Cooperative Ewing Sarcoma Study and the Late Effects Surveillance System of the Society for Paediatric Oncology and Haematology recommend a structured follow-up imaging protocol (FUIP) for patients with Ewing sarcoma (EwS) with decreasing frequency of imaging over the first 5 years. The present study aims to assess the effectiveness of the FUIP for EwS patients regarding survival after relapse.PATIENTS AND METHODS: A retrospective multicenter analysis on 160 eligible patients with EwS recurrence was performed. Potential survival differences following recurrence diagnosis between patients with protocol-detected and symptomatic relapse were investigated using the Kaplan-Meier method. Additional subgroup analyses were performed on the relapse type. Overall survival (OS) was calculated from diagnosis of relapse to last follow-up or death.RESULTS: In the multicenter analysis, recurrence was detected by FUIP in 77 of 160 patients (48%) and due to symptoms in 83 patients (52%). Regarding the entire study population, OS was significantly superior in patients with protocol-detected relapse compared to patients with symptomatic relapse (median, 2.4 vs. 1.2 years; P < 0.001). In the subgroup analyses, patients whose lung recurrences were detected by the FUIP experienced longer survival after recurrence than those whose recurrences were detected symptomatically (P = 0.023). In the 83 symptomatic patients, pain was the most prevalent symptom of relapse (72%).CONCLUSION: FUIP may benefit survival in EwS relapse, especially in lung recurrence. Pain was the leading symptom of relapse.

KW - Journal Article

U2 - 10.1002/pbc.27011

DO - 10.1002/pbc.27011

M3 - SCORING: Journal article

C2 - 29480574

VL - 65

SP - e27011

JO - PEDIATR BLOOD CANCER

JF - PEDIATR BLOOD CANCER

SN - 1545-5009

IS - 7

ER -