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Recruitment and Baseline Characteristics of Participants in the AgeWell.de Study—A Pragmatic Cluster-Randomized Controlled Lifestyle Trial against Cognitive Decline

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Recruitment and Baseline Characteristics of Participants in the AgeWell.de Study—A Pragmatic Cluster-Randomized Controlled Lifestyle Trial against Cognitive Decline. / Röhr, Susanne; Zülke, Andrea; Luppa, Melanie; Brettschneider, Christian; Weißenborn, Marina; Kühne, Flora; Zöllinger, Isabel; Samos, Franziska-Antonia Zora; Bauer, Alexander; Döhring, Juliane; Krebs-Hein, Kerstin; Oey, Anke; Czock, David; Frese, Thomas; Gensichen, Jochen; Haefeli, Walter E.; Hoffmann, Wolfgang; Kaduszkiewicz, Hanna; König, Hans-Helmut; Thyrian, Jochen René; Wiese, Birgitt; Riedel-Heller, Steffi G.

in: INT J ENV RES PUB HE, Jahrgang 18, Nr. 2, 07.01.2021, S. 408.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Röhr, S, Zülke, A, Luppa, M, Brettschneider, C, Weißenborn, M, Kühne, F, Zöllinger, I, Samos, F-AZ, Bauer, A, Döhring, J, Krebs-Hein, K, Oey, A, Czock, D, Frese, T, Gensichen, J, Haefeli, WE, Hoffmann, W, Kaduszkiewicz, H, König, H-H, Thyrian, JR, Wiese, B & Riedel-Heller, SG 2021, 'Recruitment and Baseline Characteristics of Participants in the AgeWell.de Study—A Pragmatic Cluster-Randomized Controlled Lifestyle Trial against Cognitive Decline', INT J ENV RES PUB HE, Jg. 18, Nr. 2, S. 408. https://doi.org/10.3390/ijerph18020408

APA

Röhr, S., Zülke, A., Luppa, M., Brettschneider, C., Weißenborn, M., Kühne, F., Zöllinger, I., Samos, F-A. Z., Bauer, A., Döhring, J., Krebs-Hein, K., Oey, A., Czock, D., Frese, T., Gensichen, J., Haefeli, W. E., Hoffmann, W., Kaduszkiewicz, H., König, H-H., ... Riedel-Heller, S. G. (2021). Recruitment and Baseline Characteristics of Participants in the AgeWell.de Study—A Pragmatic Cluster-Randomized Controlled Lifestyle Trial against Cognitive Decline. INT J ENV RES PUB HE, 18(2), 408. https://doi.org/10.3390/ijerph18020408

Vancouver

Röhr S, Zülke A, Luppa M, Brettschneider C, Weißenborn M, Kühne F et al. Recruitment and Baseline Characteristics of Participants in the AgeWell.de Study—A Pragmatic Cluster-Randomized Controlled Lifestyle Trial against Cognitive Decline. INT J ENV RES PUB HE. 2021 Jan 7;18(2):408. https://doi.org/10.3390/ijerph18020408

Bibtex

@article{d3f4b340738c47f28d7183353e46a375,
title = "Recruitment and Baseline Characteristics of Participants in the AgeWell.de Study—A Pragmatic Cluster-Randomized Controlled Lifestyle Trial against Cognitive Decline",
abstract = "Targeting dementia prevention, first trials addressing multiple modifiable risk factors showed promising results in at-risk populations. In Germany, AgeWell.de is the first large-scale initiative investigating the effectiveness of a multi-component lifestyle intervention against cognitive decline. We aimed to investigate the recruitment process and baseline characteristics of the AgeWell.de participants to gain an understanding of the at-risk population and who engages in the intervention. General practitioners across five study sites recruited participants (aged 60-77 years, Cardiovascular Risk Factors, Aging, and Incidence of Dementia/CAIDE dementia risk score ≥ 9). Structured face-to-face interviews were conducted with eligible participants, including neuropsychological assessments. We analyzed group differences between (1) eligible vs. non-eligible participants, (2) participants vs. non-participants, and (3) between intervention groups. Of 1176 eligible participants, 146 (12.5%) dropped out before baseline; the study population was thus 1030 individuals. Non-participants did not differ from participants in key sociodemographic factors and dementia risk. Study participants were M = 69.0 (SD = 4.9) years old, and 52.1% were women. The average Montreal Cognitive Assessment/MoCA score was 24.5 (SD = 3.1), indicating a rather mildly cognitively impaired study population; however, 39.4% scored ≥ 26, thus being cognitively unimpaired. The bandwidth of cognitive states bears the interesting potential for differential trial outcome analyses. However, trial conduction is impacted by the COVID-19 pandemic, requiring adjustments to the study protocol with yet unclear methodological consequences.",
author = "Susanne R{\"o}hr and Andrea Z{\"u}lke and Melanie Luppa and Christian Brettschneider and Marina Wei{\ss}enborn and Flora K{\"u}hne and Isabel Z{\"o}llinger and Samos, {Franziska-Antonia Zora} and Alexander Bauer and Juliane D{\"o}hring and Kerstin Krebs-Hein and Anke Oey and David Czock and Thomas Frese and Jochen Gensichen and Haefeli, {Walter E.} and Wolfgang Hoffmann and Hanna Kaduszkiewicz and Hans-Helmut K{\"o}nig and Thyrian, {Jochen Ren{\'e}} and Birgitt Wiese and Riedel-Heller, {Steffi G.}",
year = "2021",
month = jan,
day = "7",
doi = "10.3390/ijerph18020408",
language = "English",
volume = "18",
pages = "408",
journal = "INT J ENV RES PUB HE",
issn = "1660-4601",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "2",

}

RIS

TY - JOUR

T1 - Recruitment and Baseline Characteristics of Participants in the AgeWell.de Study—A Pragmatic Cluster-Randomized Controlled Lifestyle Trial against Cognitive Decline

AU - Röhr, Susanne

AU - Zülke, Andrea

AU - Luppa, Melanie

AU - Brettschneider, Christian

AU - Weißenborn, Marina

AU - Kühne, Flora

AU - Zöllinger, Isabel

AU - Samos, Franziska-Antonia Zora

AU - Bauer, Alexander

AU - Döhring, Juliane

AU - Krebs-Hein, Kerstin

AU - Oey, Anke

AU - Czock, David

AU - Frese, Thomas

AU - Gensichen, Jochen

AU - Haefeli, Walter E.

AU - Hoffmann, Wolfgang

AU - Kaduszkiewicz, Hanna

AU - König, Hans-Helmut

AU - Thyrian, Jochen René

AU - Wiese, Birgitt

AU - Riedel-Heller, Steffi G.

PY - 2021/1/7

Y1 - 2021/1/7

N2 - Targeting dementia prevention, first trials addressing multiple modifiable risk factors showed promising results in at-risk populations. In Germany, AgeWell.de is the first large-scale initiative investigating the effectiveness of a multi-component lifestyle intervention against cognitive decline. We aimed to investigate the recruitment process and baseline characteristics of the AgeWell.de participants to gain an understanding of the at-risk population and who engages in the intervention. General practitioners across five study sites recruited participants (aged 60-77 years, Cardiovascular Risk Factors, Aging, and Incidence of Dementia/CAIDE dementia risk score ≥ 9). Structured face-to-face interviews were conducted with eligible participants, including neuropsychological assessments. We analyzed group differences between (1) eligible vs. non-eligible participants, (2) participants vs. non-participants, and (3) between intervention groups. Of 1176 eligible participants, 146 (12.5%) dropped out before baseline; the study population was thus 1030 individuals. Non-participants did not differ from participants in key sociodemographic factors and dementia risk. Study participants were M = 69.0 (SD = 4.9) years old, and 52.1% were women. The average Montreal Cognitive Assessment/MoCA score was 24.5 (SD = 3.1), indicating a rather mildly cognitively impaired study population; however, 39.4% scored ≥ 26, thus being cognitively unimpaired. The bandwidth of cognitive states bears the interesting potential for differential trial outcome analyses. However, trial conduction is impacted by the COVID-19 pandemic, requiring adjustments to the study protocol with yet unclear methodological consequences.

AB - Targeting dementia prevention, first trials addressing multiple modifiable risk factors showed promising results in at-risk populations. In Germany, AgeWell.de is the first large-scale initiative investigating the effectiveness of a multi-component lifestyle intervention against cognitive decline. We aimed to investigate the recruitment process and baseline characteristics of the AgeWell.de participants to gain an understanding of the at-risk population and who engages in the intervention. General practitioners across five study sites recruited participants (aged 60-77 years, Cardiovascular Risk Factors, Aging, and Incidence of Dementia/CAIDE dementia risk score ≥ 9). Structured face-to-face interviews were conducted with eligible participants, including neuropsychological assessments. We analyzed group differences between (1) eligible vs. non-eligible participants, (2) participants vs. non-participants, and (3) between intervention groups. Of 1176 eligible participants, 146 (12.5%) dropped out before baseline; the study population was thus 1030 individuals. Non-participants did not differ from participants in key sociodemographic factors and dementia risk. Study participants were M = 69.0 (SD = 4.9) years old, and 52.1% were women. The average Montreal Cognitive Assessment/MoCA score was 24.5 (SD = 3.1), indicating a rather mildly cognitively impaired study population; however, 39.4% scored ≥ 26, thus being cognitively unimpaired. The bandwidth of cognitive states bears the interesting potential for differential trial outcome analyses. However, trial conduction is impacted by the COVID-19 pandemic, requiring adjustments to the study protocol with yet unclear methodological consequences.

U2 - 10.3390/ijerph18020408

DO - 10.3390/ijerph18020408

M3 - SCORING: Journal article

VL - 18

SP - 408

JO - INT J ENV RES PUB HE

JF - INT J ENV RES PUB HE

SN - 1660-4601

IS - 2

ER -