Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium
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Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium. / Cannioto, Rikki A; LaMonte, Michael J; Kelemen, Linda E; Risch, Harvey A; Eng, Kevin H; Minlikeeva, Albina N; Hong, Chi-Chen; Szender, J Brian; Sucheston-Campbell, Lara; Joseph, Janine M; Berchuck, Andrew; Chang-Claude, Jenny; Cramer, Daniel W; DeFazio, Anna; Diergaarde, Brenda; Dörk, Thilo; Doherty, Jennifer A; Edwards, Robert P; Fridley, Brooke L; Friel, Grace; Goode, Ellen L; Goodman, Marc T; Hillemanns, Peter; Hogdall, Estrid; Hosono, Satoyo; Kelley, Joseph L; Kjaer, Susanne K; Klapdor, Rüdiger; Matsuo, Keitaro; Odunsi, Kunle; Nagle, Christina M; Olsen, Catherine M; Paddock, Lisa E; Pearce, Celeste L; Pike, Malcolm C; Rossing, Mary A; Schmalfeldt, Barbara; Segal, Brahm H; Szamreta, Elizabeth A; Thompson, Pamela J; Tseng, Chiu-Chen; Vierkant, Robert; Schildkraut, Joellen M; Wentzensen, Nicolas; Wicklund, Kristine G; Winham, Stacey J; Wu, Anna H; Modugno, Francesmary; Ness, Roberta B; Jensen, Allan; Webb, Penelope M; Terry, Kathryn; Bandera, Elisa V; Moysich, Kirsten B.
in: BRIT J CANCER, Jahrgang 115, Nr. 1, 14.06.2016, S. 95-101.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium
AU - Cannioto, Rikki A
AU - LaMonte, Michael J
AU - Kelemen, Linda E
AU - Risch, Harvey A
AU - Eng, Kevin H
AU - Minlikeeva, Albina N
AU - Hong, Chi-Chen
AU - Szender, J Brian
AU - Sucheston-Campbell, Lara
AU - Joseph, Janine M
AU - Berchuck, Andrew
AU - Chang-Claude, Jenny
AU - Cramer, Daniel W
AU - DeFazio, Anna
AU - Diergaarde, Brenda
AU - Dörk, Thilo
AU - Doherty, Jennifer A
AU - Edwards, Robert P
AU - Fridley, Brooke L
AU - Friel, Grace
AU - Goode, Ellen L
AU - Goodman, Marc T
AU - Hillemanns, Peter
AU - Hogdall, Estrid
AU - Hosono, Satoyo
AU - Kelley, Joseph L
AU - Kjaer, Susanne K
AU - Klapdor, Rüdiger
AU - Matsuo, Keitaro
AU - Odunsi, Kunle
AU - Nagle, Christina M
AU - Olsen, Catherine M
AU - Paddock, Lisa E
AU - Pearce, Celeste L
AU - Pike, Malcolm C
AU - Rossing, Mary A
AU - Schmalfeldt, Barbara
AU - Segal, Brahm H
AU - Szamreta, Elizabeth A
AU - Thompson, Pamela J
AU - Tseng, Chiu-Chen
AU - Vierkant, Robert
AU - Schildkraut, Joellen M
AU - Wentzensen, Nicolas
AU - Wicklund, Kristine G
AU - Winham, Stacey J
AU - Wu, Anna H
AU - Modugno, Francesmary
AU - Ness, Roberta B
AU - Jensen, Allan
AU - Webb, Penelope M
AU - Terry, Kathryn
AU - Bandera, Elisa V
AU - Moysich, Kirsten B
PY - 2016/6/14
Y1 - 2016/6/14
N2 - BACKGROUND: Little is known about modifiable behaviours that may be associated with epithelial ovarian cancer (EOC) survival. We conducted a pooled analysis of 12 studies from the Ovarian Cancer Association Consortium to investigate the association between pre-diagnostic physical inactivity and mortality.METHODS: Participants included 6806 women with a primary diagnosis of invasive EOC. In accordance with the Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. We utilised Cox proportional hazard models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) representing the associations of inactivity with mortality censored at 5 years.RESULTS: In multivariate analysis, inactive women had significantly higher mortality risks, with (HR=1.34, 95% CI: 1.18-1.52) and without (HR=1.22, 95% CI: 1.12-1.33) further adjustment for residual disease, respectively.CONCLUSION: In this large pooled analysis, lack of recreational physical activity was associated with increased mortality among women with invasive EOC.British Journal of Cancer advance online publication, 14 June 2016; doi:10.1038/bjc.2016.153 www.bjcancer.com.
AB - BACKGROUND: Little is known about modifiable behaviours that may be associated with epithelial ovarian cancer (EOC) survival. We conducted a pooled analysis of 12 studies from the Ovarian Cancer Association Consortium to investigate the association between pre-diagnostic physical inactivity and mortality.METHODS: Participants included 6806 women with a primary diagnosis of invasive EOC. In accordance with the Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. We utilised Cox proportional hazard models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) representing the associations of inactivity with mortality censored at 5 years.RESULTS: In multivariate analysis, inactive women had significantly higher mortality risks, with (HR=1.34, 95% CI: 1.18-1.52) and without (HR=1.22, 95% CI: 1.12-1.33) further adjustment for residual disease, respectively.CONCLUSION: In this large pooled analysis, lack of recreational physical activity was associated with increased mortality among women with invasive EOC.British Journal of Cancer advance online publication, 14 June 2016; doi:10.1038/bjc.2016.153 www.bjcancer.com.
U2 - 10.1038/bjc.2016.153
DO - 10.1038/bjc.2016.153
M3 - SCORING: Journal article
C2 - 27299959
VL - 115
SP - 95
EP - 101
JO - BRIT J CANCER
JF - BRIT J CANCER
SN - 0007-0920
IS - 1
ER -