Recent progress in understanding the role of Reelin in radial neuronal migration, with specific emphasis on the dentate gyrus.
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Recent progress in understanding the role of Reelin in radial neuronal migration, with specific emphasis on the dentate gyrus. / Förster, Eckart; Jossin, Yves; Zhao, Shanting; Chai, Xuejun; Frotscher, Michael; Goffinet, André M.
in: EUR J NEUROSCI, Jahrgang 23, Nr. 4, 4, 2006, S. 901-909.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Recent progress in understanding the role of Reelin in radial neuronal migration, with specific emphasis on the dentate gyrus.
AU - Förster, Eckart
AU - Jossin, Yves
AU - Zhao, Shanting
AU - Chai, Xuejun
AU - Frotscher, Michael
AU - Goffinet, André M
PY - 2006
Y1 - 2006
N2 - Ten years following identification of Reelin as the product of the gene mutated in reeler mice, the signalling pathway activated by Reelin is being progressively unravelled with the identification of lipoprotein receptors as reelin receptors, of the Dab1 adapter and of some other proximal components in target cells. However, we are still a long way from understanding the action of this complex protein during brain development and maturation. The present review is organized in two parts. First, we summarize our present understanding of Reelin signalling. Then, we review critically some cell biological mechanisms for the action of Reelin based on recent studies on the development of the dentate gyrus, which has proved an extremely useful and tractable model system.
AB - Ten years following identification of Reelin as the product of the gene mutated in reeler mice, the signalling pathway activated by Reelin is being progressively unravelled with the identification of lipoprotein receptors as reelin receptors, of the Dab1 adapter and of some other proximal components in target cells. However, we are still a long way from understanding the action of this complex protein during brain development and maturation. The present review is organized in two parts. First, we summarize our present understanding of Reelin signalling. Then, we review critically some cell biological mechanisms for the action of Reelin based on recent studies on the development of the dentate gyrus, which has proved an extremely useful and tractable model system.
M3 - SCORING: Zeitschriftenaufsatz
VL - 23
SP - 901
EP - 909
JO - EUR J NEUROSCI
JF - EUR J NEUROSCI
SN - 0953-816X
IS - 4
M1 - 4
ER -
