Recent advances on the molecular pathogenesis of prion diseases
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Recent advances on the molecular pathogenesis of prion diseases. / Glatzel, Markus; Sigurdson, Christina J.
in: BRAIN PATHOL, Jahrgang 29, Nr. 2, 03.2019, S. 245-247.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Recent advances on the molecular pathogenesis of prion diseases
AU - Glatzel, Markus
AU - Sigurdson, Christina J
N1 - This article is protected by copyright. All rights reserved.
PY - 2019/3
Y1 - 2019/3
N2 - Prion diseases continue to fascinate scientists from different disciplines since the discovery that a misfolded prion protein can act as an infectious agent. Infectious prions have caused epidemics, including kuru in humans, cervid chronic wasting disease, bovine spongiform encephalopathy (BSE) or "mad cow disease", and most recently, camel prion disease, which was identified in 2018 (1). In Kuru, spread of the disease occurred from the ingestion of prion-infected, dead relatives as part of mourning practices, whereas in chronic wasting disease, prions may be transmitted not only through ingesting prion-contaminated food, but also by exposure to a prion-contaminated environment(8, 9). In all instances, prions hold structural properties that cause different disease presentations, which can be passed on to another individual (16). This article is protected by copyright. All rights reserved.
AB - Prion diseases continue to fascinate scientists from different disciplines since the discovery that a misfolded prion protein can act as an infectious agent. Infectious prions have caused epidemics, including kuru in humans, cervid chronic wasting disease, bovine spongiform encephalopathy (BSE) or "mad cow disease", and most recently, camel prion disease, which was identified in 2018 (1). In Kuru, spread of the disease occurred from the ingestion of prion-infected, dead relatives as part of mourning practices, whereas in chronic wasting disease, prions may be transmitted not only through ingesting prion-contaminated food, but also by exposure to a prion-contaminated environment(8, 9). In all instances, prions hold structural properties that cause different disease presentations, which can be passed on to another individual (16). This article is protected by copyright. All rights reserved.
KW - Journal Article
U2 - 10.1111/bpa.12693
DO - 10.1111/bpa.12693
M3 - SCORING: Journal article
C2 - 30588674
VL - 29
SP - 245
EP - 247
JO - BRAIN PATHOL
JF - BRAIN PATHOL
SN - 1015-6305
IS - 2
ER -
