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Recanalization is the Key for Better Outcome of Thrombectomy in Basilar Artery Occlusion

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Recanalization is the Key for Better Outcome of Thrombectomy in Basilar Artery Occlusion. / Deb-Chatterji, Milani; Flottmann, Fabian; Leischner, Hannes; Alegiani, Anna; Brekenfeld, Caspar; Fiehler, Jens; Gerloff, Christian; Thomalla, Götz.

in: CLIN NEURORADIOL, Jahrgang 30, Nr. 4, 30.12.2020, S. 769-775.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Deb-Chatterji, M, Flottmann, F, Leischner, H, Alegiani, A, Brekenfeld, C, Fiehler, J, Gerloff, C & Thomalla, G 2020, 'Recanalization is the Key for Better Outcome of Thrombectomy in Basilar Artery Occlusion', CLIN NEURORADIOL, Jg. 30, Nr. 4, S. 769-775. https://doi.org/10.1007/s00062-019-00850-9

APA

Deb-Chatterji, M., Flottmann, F., Leischner, H., Alegiani, A., Brekenfeld, C., Fiehler, J., Gerloff, C., & Thomalla, G. (2020). Recanalization is the Key for Better Outcome of Thrombectomy in Basilar Artery Occlusion. CLIN NEURORADIOL, 30(4), 769-775. https://doi.org/10.1007/s00062-019-00850-9

Vancouver

Deb-Chatterji M, Flottmann F, Leischner H, Alegiani A, Brekenfeld C, Fiehler J et al. Recanalization is the Key for Better Outcome of Thrombectomy in Basilar Artery Occlusion. CLIN NEURORADIOL. 2020 Dez 30;30(4):769-775. https://doi.org/10.1007/s00062-019-00850-9

Bibtex

@article{b479317502994562b08a0652927481a8,
title = "Recanalization is the Key for Better Outcome of Thrombectomy in Basilar Artery Occlusion",
abstract = "PURPOSE: Patients with basilar artery occlusion (BAO) were excluded from previous randomized controlled trials (RCTs) of endovascular treatment (ET) for acute ischemic stroke, but are commonly treated in clinical practice. This study aimed at analyzing predictors of functional outcome of ET in patients with BAO to improve patient selection for ET.METHODS: Consecutive patients with BAO who received ET over a 2-year time period were prospectively studied. Baseline characteristics, procedural and outcome data were evaluated. Outcome was assessed by the modified Rankin Scale (mRS) 90 days after stroke. Multivariate regression analyses were performed to identify predictors of outcome across the range of the mRS, of poor outcome (mRS 5-6) and independent outcome (mRS 0-2).RESULTS: A total of 39 patients with BAO (median age: 75 years, 67% male) were included. Median baseline National Institutes of Health Stroke Scale (NIHSS) score was 24. Intravenous thrombolysis therapy (IVT) was administered in 56%. Successful recanalization assessed by a modified thrombolysis in cerebral infarction (TICI) score ≥2b was achieved in 82%. Independent outcome was observed in 30% of patients with successful recanalization, but in no patient with failed recanalization. Poor outcome was observed in 47% and 86%, respectively. Successful recanalization was associated with lower scores on the mRS at 90 days (p = 0.035), and failed recanalization was associated with an odds ratio of 13.6 for poor outcome (p = 0.036).CONCLUSION: Reperfusion is the major predictor of functional outcome in BAO in clinical practice. Failed recanalization resulted in a 13-fold increase of the risk of poor outcome. Successful recanalization is crucial to achieve a better functional outcome in BAO.",
author = "Milani Deb-Chatterji and Fabian Flottmann and Hannes Leischner and Anna Alegiani and Caspar Brekenfeld and Jens Fiehler and Christian Gerloff and G{\"o}tz Thomalla",
year = "2020",
month = dec,
day = "30",
doi = "10.1007/s00062-019-00850-9",
language = "English",
volume = "30",
pages = "769--775",
journal = "CLIN NEURORADIOL",
issn = "1869-1439",
publisher = "Springer Heidelberg",
number = "4",

}

RIS

TY - JOUR

T1 - Recanalization is the Key for Better Outcome of Thrombectomy in Basilar Artery Occlusion

AU - Deb-Chatterji, Milani

AU - Flottmann, Fabian

AU - Leischner, Hannes

AU - Alegiani, Anna

AU - Brekenfeld, Caspar

AU - Fiehler, Jens

AU - Gerloff, Christian

AU - Thomalla, Götz

PY - 2020/12/30

Y1 - 2020/12/30

N2 - PURPOSE: Patients with basilar artery occlusion (BAO) were excluded from previous randomized controlled trials (RCTs) of endovascular treatment (ET) for acute ischemic stroke, but are commonly treated in clinical practice. This study aimed at analyzing predictors of functional outcome of ET in patients with BAO to improve patient selection for ET.METHODS: Consecutive patients with BAO who received ET over a 2-year time period were prospectively studied. Baseline characteristics, procedural and outcome data were evaluated. Outcome was assessed by the modified Rankin Scale (mRS) 90 days after stroke. Multivariate regression analyses were performed to identify predictors of outcome across the range of the mRS, of poor outcome (mRS 5-6) and independent outcome (mRS 0-2).RESULTS: A total of 39 patients with BAO (median age: 75 years, 67% male) were included. Median baseline National Institutes of Health Stroke Scale (NIHSS) score was 24. Intravenous thrombolysis therapy (IVT) was administered in 56%. Successful recanalization assessed by a modified thrombolysis in cerebral infarction (TICI) score ≥2b was achieved in 82%. Independent outcome was observed in 30% of patients with successful recanalization, but in no patient with failed recanalization. Poor outcome was observed in 47% and 86%, respectively. Successful recanalization was associated with lower scores on the mRS at 90 days (p = 0.035), and failed recanalization was associated with an odds ratio of 13.6 for poor outcome (p = 0.036).CONCLUSION: Reperfusion is the major predictor of functional outcome in BAO in clinical practice. Failed recanalization resulted in a 13-fold increase of the risk of poor outcome. Successful recanalization is crucial to achieve a better functional outcome in BAO.

AB - PURPOSE: Patients with basilar artery occlusion (BAO) were excluded from previous randomized controlled trials (RCTs) of endovascular treatment (ET) for acute ischemic stroke, but are commonly treated in clinical practice. This study aimed at analyzing predictors of functional outcome of ET in patients with BAO to improve patient selection for ET.METHODS: Consecutive patients with BAO who received ET over a 2-year time period were prospectively studied. Baseline characteristics, procedural and outcome data were evaluated. Outcome was assessed by the modified Rankin Scale (mRS) 90 days after stroke. Multivariate regression analyses were performed to identify predictors of outcome across the range of the mRS, of poor outcome (mRS 5-6) and independent outcome (mRS 0-2).RESULTS: A total of 39 patients with BAO (median age: 75 years, 67% male) were included. Median baseline National Institutes of Health Stroke Scale (NIHSS) score was 24. Intravenous thrombolysis therapy (IVT) was administered in 56%. Successful recanalization assessed by a modified thrombolysis in cerebral infarction (TICI) score ≥2b was achieved in 82%. Independent outcome was observed in 30% of patients with successful recanalization, but in no patient with failed recanalization. Poor outcome was observed in 47% and 86%, respectively. Successful recanalization was associated with lower scores on the mRS at 90 days (p = 0.035), and failed recanalization was associated with an odds ratio of 13.6 for poor outcome (p = 0.036).CONCLUSION: Reperfusion is the major predictor of functional outcome in BAO in clinical practice. Failed recanalization resulted in a 13-fold increase of the risk of poor outcome. Successful recanalization is crucial to achieve a better functional outcome in BAO.

U2 - 10.1007/s00062-019-00850-9

DO - 10.1007/s00062-019-00850-9

M3 - SCORING: Journal article

C2 - 31872288

VL - 30

SP - 769

EP - 775

JO - CLIN NEURORADIOL

JF - CLIN NEURORADIOL

SN - 1869-1439

IS - 4

ER -