Reactive oxygen species as mediators of the transformed phenotype.
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Reactive oxygen species as mediators of the transformed phenotype. / Jürgensmeier, J M; Panse, Jens; Schäfer, R; Bauer, G.
in: INT J CANCER, Jahrgang 70, Nr. 5, 5, 1997, S. 587-589.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Reactive oxygen species as mediators of the transformed phenotype.
AU - Jürgensmeier, J M
AU - Panse, Jens
AU - Schäfer, R
AU - Bauer, G
PY - 1997
Y1 - 1997
N2 - Reactive oxygen species (ROS) are known to be involved in different pro- and anticarcinogenic mechanisms. However, their influence on the maintenance of the transformed phenotype has not been studied so far. Here we show that the anchorage-independent growth of transformed murine fibroblasts is inhibited by antioxidants and radical scavengers in a concentration-dependent and reversible manner. These agents also reduce TGF-beta-dependent stimulation of colony formation in soft agar, pointing to their specific interference with TGF-beta-triggered signal chains involved in the maintenance of the transformed state.
AB - Reactive oxygen species (ROS) are known to be involved in different pro- and anticarcinogenic mechanisms. However, their influence on the maintenance of the transformed phenotype has not been studied so far. Here we show that the anchorage-independent growth of transformed murine fibroblasts is inhibited by antioxidants and radical scavengers in a concentration-dependent and reversible manner. These agents also reduce TGF-beta-dependent stimulation of colony formation in soft agar, pointing to their specific interference with TGF-beta-triggered signal chains involved in the maintenance of the transformed state.
M3 - SCORING: Zeitschriftenaufsatz
VL - 70
SP - 587
EP - 589
JO - INT J CANCER
JF - INT J CANCER
SN - 0020-7136
IS - 5
M1 - 5
ER -
